

| No starting lineup changes performed this week. |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 6:29pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 6:29pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 12:08am ET |
| Started | WR | Zay Flowers BAL | Owner | Thu Nov 27 12:08am ET |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 12:06am ET |
| Benched | WR | Zay Flowers BAL | Owner | Thu Nov 27 12:06am ET |
| Benched | TE | Mason Taylor NYJ | Owner | Thu Nov 27 12:06am ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 12:06am ET |
| Started | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 12:06am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 12:06am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 7:47am ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 7:47am ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 7:47am ET |
| Started | WR | Jayden Higgins HOU | Owner | Thu Nov 27 7:47am ET |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 9:13pm ET |
| Benched | DEF | Arizona Cardinals ARI | Owner | Tue Nov 25 9:13pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 9:13pm ET |
| Started | DEF | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 9:13pm ET |
| No starting lineup changes performed this week. |
| Benched | DEF | Dallas Cowboys DAL | Owner | Wed Nov 26 10:27pm ET |
| Started | DEF | Denver Broncos DEN | Owner | Wed Nov 26 10:27pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 4:56pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:56pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 7:57am ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 7:57am ET |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 26 1:39pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 1:39pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 3:34pm ET |
| Benched | WR | Chris Godwin TB | Owner | Tue Nov 25 3:34pm ET |
| Benched | DEF | Pittsburgh Steelers PIT | Owner | Tue Nov 25 3:34pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 3:34pm ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 3:34pm ET |
| Started | DEF | Indianapolis Colts IND | Owner | Tue Nov 25 3:34pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 27 12:30am ET |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 27 12:30am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 8:13am ET |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 8:13am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:13am ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 25 8:13am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 9:24am ET |
| Benched | DEF | Carolina Panthers CAR | Owner | Tue Nov 25 9:24am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 9:24am ET |
| Started | DEF | Los Angeles Chargers LAC | Owner | Tue Nov 25 9:24am ET |