
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 9:10pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 9:10pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Wed Nov 26 9:10pm CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 9:10pm CT |
| Started | WR | Mitchell Tinsley CIN | Owner | Wed Nov 26 9:08pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 9:08pm CT |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 8:25pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:25pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 8:25pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 8:25pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 11:00am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 11:00am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Baker Mayfield TB | Owner | Thu Nov 27 9:05am CT |
| Benched | TE | Colston Loveland CHI | Owner | Thu Nov 27 9:05am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 9:05am CT |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 9:05am CT |
| Benched | TE | Dawson Knox BUF | Owner | Thu Nov 27 12:42pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 12:42pm CT |
| Benched | QB | Jalen Hurts PHI | Owner | Thu Nov 27 10:08am CT |
| Started | QB | Patrick Mahomes KC | Owner | Thu Nov 27 10:08am CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 25 3:34pm CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 3:34pm CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 25 3:34pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 3:34pm CT |
| Started | WR | Michael Wilson ARI | Owner | Tue Nov 25 3:07pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 3:05pm CT |
| Benched | RB | Isiah Pacheco KC | Owner | Tue Nov 25 10:43am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 10:43am CT |
| Benched | WR | Khalil Shakir BUF | Owner | Fri Nov 28 4:17pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Fri Nov 28 4:17pm CT |
| Benched | WR | Jauan Jennings SF | Owner | Wed Nov 26 11:13pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 11:13pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 11:13pm CT |
| Benched | RB | Raheem Mostert LV | Owner | Tue Nov 25 9:40pm CT |
| Benched | WR | Kendrick Bourne SF | Owner | Tue Nov 25 9:40pm CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 9:40pm CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 9:40pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:40pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:40pm CT |
| Benched | WR | DeAndre Hopkins BAL | Owner | Thu Nov 27 7:18am CT |
| Benched | WR | Jalen Nailor MIN | Owner | Thu Nov 27 7:18am CT |
| Benched | WR | Sterling Shepard TB | Owner | Thu Nov 27 7:18am CT |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 7:18am CT |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 7:18am CT |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 7:18am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sun Nov 30 2:09pm CT |
| Benched | TE | Theo Johnson NYG | Owner | Sun Nov 30 2:09pm CT |
| Started | WR | Tez Johnson TB | Owner | Fri Nov 28 4:05pm CT |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Fri Nov 28 4:05pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 10:57pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 10:57pm CT |
| Started | QB | Matthew Stafford LAR | Owner | Wed Nov 26 10:57pm CT |
| Benched | WR | Tez Johnson TB | Owner | Wed Nov 26 10:57pm CT |
| Benched | WR | Greg Dortch ARI | Owner | Wed Nov 26 10:57pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 10:57pm CT |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 8:05pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 8:05pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 12:30pm CT |
| Started | WR | D.J. Moore CHI | Owner | Thu Nov 27 12:30pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 12:24pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 12:24pm CT |