

| On IR: | |||
| Trey Benson | |||
| L.j. Collier | |||
| James Conner | |||
| Justin Jones | |||
| Tip Reiman | |||
| J.J. Russell | |||
| Garrett Williams | |||
| Physically Unable To Perform: | |||
| BJ Ojulari | |||
| Questionable: | |||
| Zay Jones | Knee | ||
| Max Melton | Hamstring | ||
| Kyler Murray | Foot | ||
| Cody Simon | Knee | ||
| Mack Wilson | Ankle | ||
| Out: | |||
| Darius Robinson | Pectoral | ||
| On IR: | |||
| Jordan Fuller | |||
| On IR - Designated For Return: | |||
| Ta'Quon Graham | |||
| Physically Unable To Perform: | |||
| Troy Andersen | |||
| Questionable: | |||
| Billy Bowman Jr. | Knee | ||
| Natrone Brooks | Concussion | ||
| Out: | |||
| LaCale London | Triceps | ||
| Darnell Mooney | Hamstring | ||
| Clark Phillips III | Triceps | ||
| On IR: | |||
| Bilhal Kone | |||
| Robert Longerbeam | |||
| Justin Madubuike | |||
| Broderick Washington Jr. | |||
| On IR - Designated For Return: | |||
| Adisa Isaac | |||
| Physically Unable To Perform: | |||
| Ar'Darius Washington | |||
| Questionable: | |||
| Zay Flowers | Shoulder | ||
| Out: | |||
| Chidobe Awuzie | Hamstring | ||
| Lamar Jackson | Hamstring | ||
| Patrick Ricard | Calf | ||
| Roquan Smith | Hamstring | ||
| Devontez Walker | Oblique | ||
| On IR: | |||
| Tyler Bass | |||
| DeWayne Carter | |||
| Gabriel Davis | |||
| Maxwell Hairston | |||
| Damar Hamlin | |||
| T.J. Sanders | |||
| Dorian Strong | |||
| Suspended: | |||
| Michael Hoecht | |||
| Larry Ogunjobi | |||
| Questionable: | |||
| Dalton Kincaid | Oblique | ||
| Curtis Samuel | Neck | ||
| Out: | |||
| Matt Milano | Pectoral | ||
| On IR: | |||
| Damarri Mathis | |||
| David Moore | |||
| On IR - Designated For Return: | |||
| Jalen Coker | |||
| Physically Unable To Perform: | |||
| Jonathon Brooks | |||
| Questionable: | |||
| Michael Jackson | Ribs | ||
| Ja'Tavion Sanders | Ankle | ||
| Chau Smith-Wade | Chest | ||
| Out: | |||
| Akayleb Evans | Hamstring | ||
| Chuba Hubbard | Calf | ||
| Tershawn Wharton | Toe | ||
| On IR: | |||
| Deion Hankins | |||
| Jaylon Johnson | |||
| Terell Smith | |||
| On IR - Designated For Return: | |||
| Austin Booker | |||
| Travis Homer | |||
| Amen Ogbongbemiga | |||
| Questionable: | |||
| Colston Loveland | Hip | ||
| Cairo Santos | Thigh | ||
| Out: | |||
| Grady Jarrett | Knee | ||
| On IR: | |||
| Joe Burrow | |||
| On IR - Designated For Return: | |||
| Daijahn Anthony | |||
| Cedric Johnson | |||
| Physically Unable To Perform: | |||
| Erick All | |||
| Questionable: | |||
| Ja'Marr Chase | Rest | ||
| Doubtful: | |||
| Shemar Stewart | Ankle | ||
| On IR: | |||
| DeAndre Carter | |||
| Martin Emerson | |||
| Cedric Tillman | |||
| Nathaniel Watson | |||
| On IR - Designated For Return: | |||
| Winston Reid | |||
| Physically Unable To Perform: | |||
| Jeremiah Owusu-Koramoah | |||
| Deshaun Watson | |||
| Out: | |||
| Michael Hall Jr. | Knee | ||
| On IR: | |||
| Malik Hooker | |||
| Phil Mafah | |||
| Miles Sanders | |||
| John Stephens Jr. | |||
| Perrion Winfrey | |||
| On IR - Designated For Return: | |||
| Caelen Carson | |||
| Jonathan Mingo | |||
| Payton Turner | |||
| Physically Unable To Perform: | |||
| Josh Butler | |||
| DeMarvion Overshown | |||
| Questionable: | |||
| DaRon Bland | Shoulder | ||
| Trevon Diggs | Knee | ||
| Marshawn Kneeland | Ankle | ||
| Out: | |||
| CeeDee Lamb | Ankle | ||
| Jack Sanborn | Concussion | ||
| KaVontae Turpin | Foot | ||
| On IR: | |||
| Michael Burton | |||
| Dre Greenlaw | |||
| Matt Henningsen | |||
| Lucas Krull | |||
| On IR - Designated For Return: | |||
| Drew Sanders | |||
| Out: | |||
| Jonah Elliss | Ribs | ||
| On IR: | |||
| Marcus Davenport | |||
| Khalil Dorsey | |||
| Dan Jackson | |||
| Ennis Rakestraw Jr. | |||
| D.J. Reed | |||
| Daniel Thomas | |||
| Ezekiel Turner | |||
| Kenny Yeboah | |||
| Shane Zylstra | |||
| On IR - Designated For Return: | |||
| Alim McNeill | |||
| Physically Unable To Perform: | |||
| Levi Onwuzurike | |||
| Malcolm Rodriguez | |||
| Questionable: | |||
| Brian Branch | Ankle | ||
| Kerby Joseph | Knee | ||
| Avonte Maddox | Hamstring | ||
| Kalif Raymond | Neck | ||
| Out: | |||
| Terrion Arnold | Shoulder | ||
| Zach Cunningham | Hamstring | ||
| Sione Vaki | Groin | ||
| On IR: | |||
| Jayden Reed | |||
| On IR - Designated For Return: | |||
| MarShawn Lloyd | |||
| Christian Watson | |||
| Physically Unable To Perform: | |||
| Collin Oliver | |||
| Questionable: | |||
| Nate Hobbs | Concussion | ||
| Brandon McManus | Right Quadricep | ||
| Out: | |||
| Devonte Wyatt | Knee | ||
| On IR: | |||
| Folorunso Fatukasi | |||
| Kyonte Hamilton | |||
| Jakob Johnson | |||
| Brevin Jordan | |||
| Jaylin Smith | |||
| Cade Stover | |||
| Justin Watson | |||
| On IR - Designated For Return: | |||
| Denico Autry | |||
| Jaylen Reed | |||
| Physically Unable To Perform: | |||
| Tank Dell | |||
| Jimmie Ward | |||
| On IR: | |||
| Salvon Ahmed | |||
| Joe Bachie | |||
| Mike Hilton | |||
| Jaylon Jones | |||
| D.J. Montgomery | |||
| Jacob Phillips | |||
| Daniel Scott | |||
| Spencer Shrader | |||
| Justin Walley | |||
| Hunter Wohler | |||
| On IR - Designated For Return: | |||
| Jaylon Carlies | |||
| Out: | |||
| Tyler Goodson | Groin | ||
| Kenny Moore | Achilles | ||
| On IR: | |||
| Joshua Cephus | |||
| Caleb Ransaw | |||
| Brenton Strange | |||
| On IR - Designated For Return: | |||
| Jalen McLeod | |||
| Questionable: | |||
| Yasir Abdullah | Hamstring | ||
| On IR: | |||
| Felix Anudike-Uzomah | |||
| Jake Briningstool | |||
| Deon Bush | |||
| Keaontay Ingram | |||
| Nazeeh Johnson | |||
| Janarius Robinson | |||
| Eric Scott Jr. | |||
| Suspended: | |||
| Rashee Rice | |||
| On IR: | |||
| Junior Colson | |||
| Omarion Hampton | |||
| Da'Shawn Hand | |||
| Najee Harris | |||
| Khalil Mack | |||
| On IR - Designated For Return: | |||
| Deane Leonard | |||
| Denzel Perryman | |||
| Questionable: | |||
| Bud Dupree | Hamstring | ||
| Quentin Johnston | Hamstring | ||
| Scott Matlock | Ankle | ||
| Out: | |||
| Derius Davis | Knee | ||
| On IR: | |||
| Ahkello Witherspoon | |||
| Questionable: | |||
| Tutu Atwell | Hamstring | ||
| Colby Parkinson | Concussion | ||
| Doubtful: | |||
| Omar Speights | Ankle | ||
| On IR: | |||
| Brennan Jackson | |||
| Aidan O'Connell | |||
| On IR - Designated For Return: | |||
| Lonnie Johnson | |||
| Out: | |||
| Brock Bowers | Knee | ||
| On IR: | |||
| Artie Burns | |||
| Jalin Conyers | |||
| Tyreek Hill | |||
| Kader Kohou | |||
| Jason Marshall Jr. | |||
| Alexander Mattison | |||
| On IR - Designated For Return: | |||
| Jason Sanders | |||
| Questionable: | |||
| Storm Duck | Ankle | ||
| Out: | |||
| Elijah Campbell | Quadricep | ||
| Tyrel Dodson | Concussion | ||
| On IR: | |||
| Blake Cashman | |||
| Ty Chandler | |||
| Aaron Jones | |||
| Rondale Moore | |||
| Physically Unable To Perform: | |||
| Gavin Bartholomew | |||
| On IR: | |||
| Marcellas Dial | |||
| Antonio Gibson | |||
| Lan Larison | |||
| Deneric Prince | |||
| Jaquelin Roy | |||
| Questionable: | |||
| Christian Gonzalez | Hamstring | ||
| Marte Mapu | Neck | ||
| Out: | |||
| Jaylinn Hawkins | Hamstring | ||
| Anfernee Jennings | Ankle | ||
| Keion White | Elbow | ||
| On IR: | |||
| Julian Blackmon | |||
| Vernon Broughton | |||
| Bub Means | |||
| Trey Palmer | |||
| Ja'Lynn Polk | |||
| On IR - Designated For Return: | |||
| John Ridgeway | |||
| Questionable: | |||
| Alvin Kamara | Ankle | ||
| Out: | |||
| Isaac Yiadom | Hamstring | ||
| On IR: | |||
| Chris Board | |||
| Da'Quan Felton | |||
| Bryce Ford-Wheaton | |||
| Graham Gano | |||
| Micah McFadden | |||
| Malik Nabers | |||
| Physically Unable To Perform: | |||
| Victor Dimukeje | |||
| Eric Gray | |||
| Anthony Johnson Jr. | |||
| Out: | |||
| Demetrius Flannigan-Fowles | Hamstring | ||
| Darius Slayton | Hamstring | ||
| On IR: | |||
| Braelon Allen | |||
| Kris Boyd | |||
| Byron Cowart | |||
| Marcelino McCrary-Ball | |||
| Keilan Robinson | |||
| Quincy Williams | |||
| Physically Unable To Perform: | |||
| Irvin Charles | |||
| Questionable: | |||
| Brandon Stephens | Neck | ||
| Out: | |||
| Michael Carter II | Concussion | ||
| Allen Lazard | Personal | ||
| On IR: | |||
| Jakorian Bennett | |||
| Darius Cooper | |||
| Ogbonnia Okoronkwo | |||
| Nolan Smith | |||
| Johnny Wilson | |||
| Questionable: | |||
| Jalen Carter | Heel | ||
| Nakobe Dean | Knee | ||
| Out: | |||
| Grant Calcaterra | Oblique | ||
| On IR: | |||
| Malik Harrison | |||
| Will Howard | |||
| Donte Kent | |||
| Isaiahh Loudermilk | |||
| Dean Lowry | |||
| Donald Parham | |||
| Skylar Thompson | |||
| On IR - Designated For Return: | |||
| Cory Trice Jr. | |||
| Questionable: | |||
| Jalen Ramsey | Hamstring | ||
| Out: | |||
| Calvin Austin III | Shoulder | ||
| On IR: | |||
| Kenny McIntosh | |||
| Robbie Ouzts | |||
| Jacardia Wright | |||
| Doubtful: | |||
| Julian Love | Hamstring | ||
| Devon Witherspoon | Knee | ||
| Out: | |||
| Derick Hall | Oblique | ||
| Tariq Woolen | Concussion | ||
| On IR: | |||
| Nick Bosa | |||
| Jacob Cowing | |||
| Tre'Vius Hodges-Tomlinson | |||
| Tarron Jackson | |||
| George Kittle | |||
| Trent Taylor | |||
| Patrick Taylor | |||
| On IR - Designated For Return: | |||
| Kevin Givens | |||
| Physically Unable To Perform: | |||
| Brandon Aiyuk | |||
| Questionable: | |||
| Alfred Collins | Knee | ||
| Kalia Davis | Hand | ||
| Jauan Jennings | Ankle | ||
| Mac Jones | Knee | ||
| Malik Mustapha | Knee | ||
| Upton Stout | Ankle | ||
| Out: | |||
| Yetur Gross-Matos | Knee | ||
| Ricky Pearsall | Knee | ||
| Brock Purdy | Toe | ||
| Jordan Watkins | Calf | ||
| On IR: | |||
| Calijah Kancey | |||
| Ko Kieft | |||
| Jalen McMillan | |||
| David Walker | |||
| Rashad Wisdom | |||
| Questionable: | |||
| Christian Izien | Quad | ||
| Out: | |||
| Mike Evans | Hamstring | ||
| Chris Godwin | Shin | ||
| Bucky Irving | Foot | ||
| Zyon McCollum | Thumb | ||
| Benjamin Morrison | Hamstring | ||
| Josh Williams | Concussion | ||
| On IR: | |||
| Mike Brown | |||
| Will Levis | |||
| Kalel Mullings | |||
| Anfernee Orji | |||
| T'Vondre Sweat | |||
| Blake Watson | |||
| Questionable: | |||
| Van Jefferson | Ankle | ||
| Out: | |||
| Marcus Harris | Calf | ||
| Arden Key | Quad | ||
| Bryce Oliver | Knee | ||
| Joey Slye | Calf | ||
| On IR: | |||
| Austin Ekeler | |||
| Will Harris | |||
| Tyree Jackson | |||
| Javontae Jean-Baptiste | |||
| Jonathan Jones | |||
| Deatrich Wise | |||
| Questionable: | |||
| Eddie Goldman | Illness | ||
| Chris Rodriguez Jr. | Calf | ||
| Deebo Samuel | Heel | ||
| Out: | |||
| Noah Brown | Groin | ||
| Terry McLaurin | Quad | ||