

| On IR: | |||
| Taven Bryan | |||
| Justice Hill | |||
| Bilhal Kone | |||
| Robert Longerbeam | |||
| Justin Madubuike | |||
| Broderick Washington Jr. | |||
| On IR - Designated For Return: | |||
| Adisa Isaac | |||
| Questionable: | |||
| Rashod Bateman | Ankle | ||
| Tavius Robinson | Foot | ||
| Ar'Darius Washington | Achilles | ||
| On IR: | |||
| Tyler Bass | |||
| DeWayne Carter | |||
| Damar Hamlin | |||
| Mecole Hardman | |||
| Michael Hoecht | |||
| Landon Jackson | |||
| Ed Oliver | |||
| Taylor Rapp | |||
| Curtis Samuel | |||
| Dorian Strong | |||
| Questionable: | |||
| Christian Benford | Toe | ||
| Terrel Bernard | Elbow | ||
| Josh Palmer | Ankle | ||
| On IR: | |||
| Patrick Jones II | |||
| Damarri Mathis | |||
| David Moore | |||
| Physically Unable To Perform: | |||
| Jonathon Brooks | |||
| Questionable: | |||
| Tershawn Wharton | Hamstring | ||
| On IR: | |||
| Tremaine Edmunds | |||
| Kyler Gordon | |||
| Deion Hankins | |||
| Roschon Johnson | |||
| Dayo Odeyingbo | |||
| Terell Smith | |||
| Shemar Turner | |||
| Questionable: | |||
| Rome Odunze | Foot | ||
| Out: | |||
| Travis Homer | Ankle | ||
| On IR: | |||
| Michael Burton | |||
| J.K. Dobbins | |||
| Matt Henningsen | |||
| Lucas Krull | |||
| On IR - Designated For Return: | |||
| Drew Sanders | |||
| Out: | |||
| Pat Bryant | Hamstring | ||
| On IR: | |||
| Terrion Arnold | |||
| Brian Branch | |||
| Zach Cunningham | |||
| Dan Jackson | |||
| Sam LaPorta | |||
| Ennis Rakestraw Jr. | |||
| Ezekiel Turner | |||
| Brock Wright | |||
| On IR - Designated For Return: | |||
| Josh Paschal | |||
| Physically Unable To Perform: | |||
| Levi Onwuzurike | |||
| Questionable: | |||
| Kalif Raymond | Ankle | ||
| Sione Vaki | Thumb | ||
| Shane Zylstra | Knee | ||
| Out: | |||
| Kerby Joseph | Knee | ||
| On IR: | |||
| Tucker Kraft | |||
| Nick Niemann | |||
| Devonte Wyatt | |||
| On IR - Designated For Return: | |||
| MarShawn Lloyd | |||
| Collin Oliver | |||
| Questionable: | |||
| Josh Jacobs | Knee | ||
| Lukas Van Ness | Foot | ||
| Savion Williams | Foot | ||
| Emanuel Wilson | Illness | ||
| On IR: | |||
| Folorunso Fatukasi | |||
| Kyonte Hamilton | |||
| Brevin Jordan | |||
| Jaylen Reed | |||
| Tim Settle | |||
| Jaylin Smith | |||
| M.J. Stewart | |||
| Darrell Taylor | |||
| On IR - Designated For Return: | |||
| Justin Watson | |||
| Physically Unable To Perform: | |||
| Tank Dell | |||
| Jimmie Ward | |||
| Questionable: | |||
| Harrison Bryant | Neck | ||
| Nick Chubb | Ribs | ||
| EJ Speed | Knee | ||
| On IR: | |||
| Joshua Cephus | |||
| Travis Hunter | |||
| Caleb Ransaw | |||
| On IR - Designated For Return: | |||
| Jalen McLeod | |||
| Questionable: | |||
| Parker Washington | Hip | ||
| On IR: | |||
| Junior Colson | |||
| Tucker Fisk | |||
| Najee Harris | |||
| Hassan Haskins | |||
| Questionable: | |||
| Troy Dye | Hip | ||
| Quentin Johnston | Groin | ||
| Doubtful: | |||
| Elijah Molden | Hamstring | ||
| Out: | |||
| Derius Davis | Ankle | ||
| On IR: | |||
| Tyler Higbee | |||
| Quentin Lake | |||
| Roger McCreary | |||
| On IR - Designated For Return: | |||
| Tutu Atwell | |||
| Questionable: | |||
| Davante Adams | Hamstring | ||
| On IR: | |||
| Alex Austin | |||
| Jashaun Corbin | |||
| Marcellas Dial | |||
| Antonio Gibson | |||
| Darius Harris | |||
| Terrell Jennings | |||
| Lan Larison | |||
| Deneric Prince | |||
| Craig Reynolds | |||
| Jaquelin Roy | |||
| Milton Williams | |||
| Questionable: | |||
| Robert Spillane | Foot | ||
| On IR: | |||
| Andrew Mukuba | |||
| Azeez Ojulari | |||
| Ogbonnia Okoronkwo | |||
| Johnny Wilson | |||
| Out: | |||
| Jalen Carter | Shoulders | ||
| On IR: | |||
| DeShon Elliott | |||
| Miles Killebrew | |||
| Isaiahh Loudermilk | |||
| Dean Lowry | |||
| Donald Parham | |||
| Skylar Thompson | |||
| Suspended: | |||
| Daniel Ekuale | |||
| On IR - Designated For Return: | |||
| Donte Kent | |||
| Cory Trice Jr. | |||
| Questionable: | |||
| Derrick Harmon | Knee | ||
| D.K. Metcalf | Stomach | ||
| Darnell Washington | Concussion | ||
| Out: | |||
| T.J. Watt | Lung | ||
| On IR: | |||
| Elijah Arroyo | |||
| George Holani | |||
| Tory Horton | |||
| Julian Love | |||
| Kenny McIntosh | |||
| Jarran Reed | |||
| Chazz Surratt | |||
| Jacardia Wright | |||
| On IR - Designated For Return: | |||
| Dareke Young | |||
| Questionable: | |||
| Rylie Mills | Knee | ||
| Eric Saubert | Calf | ||
| On IR: | |||
| Nick Bosa | |||
| Jacob Cowing | |||
| Tre'Vius Hodges-Tomlinson | |||
| Tarron Jackson | |||
| Trent Taylor | |||
| Patrick Taylor | |||
| Fred Warner | |||
| Mykel Williams | |||
| On IR - Designated For Return: | |||
| Yetur Gross-Matos | |||
| Kurtis Rourke | |||
| Physically Unable To Perform: | |||
| Brandon Aiyuk | |||
| Questionable: | |||
| Christian McCaffrey | NIR-Rest | ||
| Out: | |||
| Tatum Bethune | Ankle | ||
| Nick Martin | Concussion | ||
| Sam Okuayinonu | Ankle | ||
| On IR: | |||
| Calijah Kancey | |||
| Ko Kieft | |||
| David Walker | |||
| Rashad Wisdom | |||
| Suspended: | |||
| Josh Williams | |||
| Questionable: | |||
| Mike Evans | Collarbone | ||
| Jalen McMillan | Neck | ||
| Doubtful: | |||
| Cade Otton | Knee | ||
| Tykee Smith | Neck | ||
| Out: | |||
| SirVocea Dennis | Hip | ||