San Francisco 49ers wide receiver Jordan Watkins (coach's decision) and running back Jordan James (coach's decision) are both healthy scratches for Week 2 against the New Orleans Saints. Watkins and James both missed last week's season opener, and even though they're healthy for Week 2, the rookies will watch Sunday's game from the sideline. Kendrick Bourne, Marquez Valdes-Scantling, and Skyy Moore will round out the wide receiver room behind Jauan Jennings and Ricky Pearsall. Meanwhile, Isaac Guerendo will handle RB3 duties behind Christian McCaffrey and Brian Robinson Jr.

From RotoBaller

According to CBS Sports, Cleveland Browns rookie second-round running back Quinshon Judkins will start in his NFL debut in Week 2 against the Baltimore Ravens. Judkins may get the "start," but NFL Network's Ian Rapoport also reported on Sunday morning that the Browns plan to give Judkins backup touches -- around 10 to 15 in his first NFL game. Fantasy managers will be happy to get a look at the Ohio State product, but it would be a mistake to throw him into your starting lineup right away with the Browns easing him into their offense after he missed all of training camp, the preseason, and the Week 1 loss to the Cincinnati Bengals. Judkins should be Cleveland's RB1 by season's end, but it won't be right away, and he could also be facing a suspension of two to four games after a domestic-violence case over the summer.

From RotoBaller

New York Jets wide receiver Allen Lazard will make his 2025 debut in Week 2 against the division-rival Buffalo Bills on Sunday after he was a healthy scratch in the season-opening loss last Sunday to the Pittsburgh Steelers. Lazard might only be active because Josh Reynolds is out with a hamstring injury. Although it's notable for New York's passing attack, we wouldn't recommend the 29-year-old as a streaming option this weekend, even in deep fantasy leagues. Garrett Wilson will continue to draw the majority of aerial targets from quarterback Justin Fields. Lazard, who has struggled with drops in his two seasons with the Jets, will be competing for targets with Tyler Johnson mostly. Last year in New York, Lazard bounced back from a rough 2023 campaign to catch 37 passes for 530 yards and six touchdowns in 12 games (10 starts).

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The Philadelphia Eagles are "looking to get A.J. Brown involved more and early" on Sunday against the Kansas City Chiefs, according to NFL Network's Mike Garafolo. He noted that the Eagles had several plays dialed up for Brown to get more targets last week, but they didn't work out, and the star receiver finished Week 1 with just one reception. Based on Garafolo's comments, it appears that last week should be treated as an anomaly, and Brown will be more involved in Week 2. An increased target share could come naturally for Brown as the Eagles will be without Dallas Goedert (knee), who caught seven passes in the season opener.

From RotoBaller

Baltimore Ravens running back Keaton Mitchell finds himself as a healthy inactive for the second straight week to open the season in Week 2 against the division-rival Cleveland Browns on Sunday. To begin the 2025 campaign, Mitchell has found himself as the team's RB4 behind Derrick Henry, Justice Hill, and Rasheen Ali. The 23-year-old has intriguing power and explosiveness, but he's had trouble staying on the field early in his career, playing only 13 games (two starts) since entering the league in 2023. He has averaged a healthy 6.9 yards per carry on his 62 rushing attempts with 426 yards and two touchdowns, but right now, he's off the fantasy radar altogether in redraft leagues. Mitchell's next chance to make his 2025 debut will be in Week 3 against the Detroit Lions on Monday, Sept. 22.

From RotoBaller

New York Jets rookie tight end Mason Taylor (ankle) is officially active and will play on Sunday against the division-rival Buffalo Bills at MetLife Stadium. Taylor was listed as questionable on the final Week 2 injury report, but he will be available for the Jets and fantasy managers. The 21-year-old second-rounder played 88 percent of the offensive snaps in the Week 1 loss to the Pittsburgh Steelers, but he only had one catch (on one target) for 20 yards, despite the team putting up 30 points. He'll be looking to increase his production against a Bills defense that just gave up 40 points to the Baltimore Ravens in Week 1, although Ravens tight end Mark Andrews only had one catch for five yards. Fantasy managers should consider Taylor more of a TE3 on Sunday in just his second NFL game.

From RotoBaller

Miami Dolphins running back Jaylen Wright (knee), who was listed as doubtful on Friday's final injury report, is officially out for Sunday's Week 2 divisional clash against the New England Patriots. Wright had a minor surgery on his right knee in late August and was always expected to miss time early in the 2025 season. With a quick turnaround next Thursday night in another divisional tilt against the Buffalo Bills, Wright is probably going to be facing an uphill battle to make his season debut. When fully healthy, the explosive and fast Wright should operate as De'Von Achane's primary backup. Miami's offense looked terrible in the Week 1 loss to the Indianapolis Colts, giving rookie Ollie Gordon II limited opportunities to make noise behind Achane. Fantasy managers should not be starting Gordon against the Pats with Wright out again.

From RotoBaller

Buffalo Bills veteran wide receiver Curtis Samuel is once again a healthy inactive for Sunday's Week 2 divisional contest on the road against the New York Jets. Samuel was also a healthy scratch for the season-opening win over the Baltimore Ravens last Sunday night. Right now, the 29-year-old is buried on Buffalo's receiver depth chart, thanks to the offseason additions of Joshua Palmer and Elijah Moore. Khalil Shakir, Keon Coleman, and Tyrell Shavers are also ahead of him. Samuel should remain on the waiver wire in all fantasy formats for now. In his first year with Buffalo in 2024, he caught 31 of his 46 targets for 253 yards and only one touchdown in 14 regular-season games (two starts).

From RotoBaller

The Chicago Bears have declared DE Shemar Turner, OT Ozzy Trapilo, QB Case Keenum, OT Kiran Amegadjie, WR Jahdae Walker and CB Kyler Gordon inactive for Week 2.

From TheHuddle

Baltimore Ravens CB Jaire Alexander (knee) has been declared inactive for the Week 2 game.

From TheHuddle

The Miami Dolphins have declared TE Darren Waller, CB Storm Duck, WR Tahj Washington, RB Jaylen Wright, DB Ethan Bonner, DT Benito Jones and QB Quinn Ewers inactive for Week 2.

From TheHuddle

Tennessee Titans rookie running back Kalel Mullings (ankle) has officially been ruled out of Week 2 against the visiting Los Angeles Rams on Sunday. Mullings made his NFL debut in last week's loss to the Denver Broncos as the RB3 behind Tony Pollard and Julius Chestnut, but was quickly injured in the first half on special teams. The 22-year-old sixth-rounder didn't see a single touch on offense in the 20-12 loss in Denver. With Tyjae Spears (ankle) on Injured Reserve and set to miss at least the first four weeks of the season, Tennessee's backfield depth behind Pollard and Chestnut is dangerously thin. Now that Mullings is out, the Titans were forced to bring up Jordan Mims from the practice squad for Sunday's game against the Rams. He'll operate as the team's No. 3 RB in Week 2.

From RotoBaller

New England Patriots rookie wide receiver Efton Chism III is once again a healthy scratch for Week 2 on Sunday versus the division-rival Miami Dolphins at Hard Rock Stadium. Chism impressed the coaching staff in training camp and the preseason, but it wasn't enough to put him on the active game-day roster the first two weeks of 2025. The 23-year-old was an undrafted free agent and has more work to do to get on the field on Sundays in his first NFL season. For now, he's just a bench stash in deep dynasty/keeper fantasy leagues. At the moment, he's blocked by receivers Stefon Diggs, DeMario Douglas, Kayshon Boutte, Mack Hollins, and Kyle Williams. If an injury arises to any of New England's receivers, Chism will likely be the first to benefit.

From RotoBaller

The New Orleans Saints have declared DT Khristian Boyd, OG Trevor Penning, WR Trey Palmer, DL Jonathan Bullard, OT Xavier Truss, DE Chase Young and CB Rejzohn Wright inactive for Week 2.

From TheHuddle

The Baltimore Ravens have declared LB David Ojabo, RB Keaton Mitchell, OT Carson Vinson, RB Patrick Ricard, TE Isaiah Likely and CB Jaire Alexander inactive for Week 2.

From TheHuddle

Detroit Lions running back Sione Vaki (hamstring) is officially inactive for Sunday's Week 2 contest against the Chicago Bears. He was limited in practice this week but was not expected to play after the Lions listed him as doubtful. The 24-year-old played in 16 games last year, totaling 51 scrimmage yards, but has not yet stepped on the field in his second pro campaign. Craig Reynolds will continue to operate as the Lions' No. 3 running back behind Jahmyr Gibbs and David Montgomery.

From RotoBaller

For the second straight week to begin the 2025 season, Cincinnati Bengals wide receiver Jermaine Burton is a healthy inactive for the Week 2 contest against the Jacksonville Jaguars. Burton had a pretty rough rookie season in 2024 that involved some maturity issues, but he got rave reviews during training camp in the summer. For now, though, Charlie Jones is ahead of him as the team's WR4 behind Ja'Marr Chase, Tee Higgins, and Andrei Iosivas. The 24-year-old former third-rounder caught four passes for 107 yards on 14 targets in 14 games in his rookie season. Burton isn't anywhere close to the fantasy radar in redraft leagues right now.

From RotoBaller

Chicago Bears wide receiver Jahdae Walker (ankle) is officially inactive for Sunday's Week 2 contest against the Detroit Lions. He had been listed as doubtful after missing practice on Friday. The 23-year-old did suit up in last week's season opener, but he only played on special teams. Chicago should have no trouble replacing him on special teams this week, and his absence has no impact on the Bears' offense or fantasy managers' lineups.

From RotoBaller

New York Giants wide receiver Wan'Dale Robinson (ankle) is officially active for Sunday's Week 2 contest against the Dallas Cowboys. He had been listed as questionable after practicing in a limited capacity on Friday. Having Robinson available will be key for the Giants, as he's their second-best option in the passing game behind Malik Nabers. The 24-year-old was productive in last week's season opener, catching six of eight targets for 55 yards. He should continue to deliver similar productivity this week against the Cowboys, as the Giants are expected to throw the ball a lot while playing from behind. He ranks as a mid-range WR3/flex, especially in PPR leagues.

From RotoBaller

Dallas Cowboys running back Jaydon Blue (coach's decision) is inactive for Sunday's Week 2 contest against the New York Giants. The fifth-round rookie has now been a healthy scratch for each of the Cowboys' first two games of the season. In his absence, Miles Sanders will serve as the backup running back behind Javonte Williams. Sanders and Williams are the Cowboys' only two active running backs, but fullback Hunter Luepke should also see some blocking work in the backfield. Fantasy managers in deeper leagues should be patient with Blue and hold onto him, as it's likely only a matter of time before he's active as the No. 3 running back or leapfrogs Miles Sanders for the backup job.

From RotoBaller