Even though Minnesota Vikings quarterback J.J. McCarthy (concussion) was able to participate in a limited practice on Wednesday, rookie Max Brosmer took all of the first-team reps, according to Kevin Seifert of ESPN. McCarthy came down with a concussion in the Week 12 loss to the Green Bay Packers and is not expected to play in this week's game in Seattle against the Seahawks, so the Vikings are preparing Brosmer to make the first start of his career. The undrafted free-agent rookie QB will be thrown to the wolves on the road this Sunday against a strong Seahawks defense, so fantasy managers shouldn't expect a whole lot from the Vikings' offense. McCarthy has been extremely inconsistent in his first year of NFL action, but Brosmer won't necessarily be an upgrade. The 24-year-old has gone just 5-for-8 passing for 42 yards with no touchdowns or interceptions in parts of three games played in 2025.

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The San Francisco 49ers will not open the 21-day practice window for wide receiver Brandon Aiyuk (knee) this week, according to head coach Kyle Shanahan. The same goes for fellow wideout Jacob Cowing (hamstring). A report surfaced last week that the 49ers voided guarantees in Aiyuk's four-year contract extension, which could lead to the 27-year-old former first-rounder sitting out the entire 2025 campaign. If that happens, the 49ers would likely release him at season's end. Fantasy managers who have been stashing Aiyuk all season long might not get to use him at all. It's good news for the rest-of-season outlooks for both Jauan Jennings and Ricky Pearsall, as well as tight end George Kittle. Aiyuk has been recovering from his season-ending injury last year, in which he tore both his ACL and MCL.

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The Green Bay Packers are listing rookie first-round wide receiver Matthew Golden (wrist) as questionable for Thursday's game against the division-rival Detroit Lions on Thanksgiving Day, according to Adam Schefter of ESPN. Golden missed last week's win over the Minnesota Vikings with shoulder and wrist injuries. The 22-year-old is past his shoulder injury, but he's still up in the air to play in Week 13 after being limited in practice this week. The Packers will not welcome Jayden Reed (foot, shoulder) back from Injured Reserve this week, but even if Golden is cleared to play against the Lions, he'll be hard to trust in a WR4/flex spot by fantasy managers. Golden has yet to display the form he showed in training camp and the preseason, and he has only 24 catches for 286 yards and no touchdowns in his first nine games in a crowded Packers' receiving corps.

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Buffalo Bills quarterback Josh Allen (elbow) was listed as a full participant in Wednesday's practice, according to the team. Allen is listed with a right-elbow injury on the Week 13 injury report, but he should be fine to play this weekend against the Pittsburgh Steelers. The 29-year-old had his left shoulder examined by trainers in last Thursday night's loss to the Houston Texans in a game in which he was constantly being hit and sacked by the No. 1 defense in the league. Allen was also seen shaking his right hand, but he assured us after the game that everything was fine. He scored a whopping six touchdowns (three passing, three rushing) in Week 11, but then laid an egg last week with zero touchdowns. He should be able to bounce back against Pittsburgh this weekend, but it sure would be nice if he could get tight end Dalton Kincaid (hamstring) and receiver Keon Coleman back.

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Green Bay Packers running back Josh Jacobs (knee) has no injury designation for Thursday's divisional clash against the Detroit Lions on Thanksgiving and is good to go, according to ESPN's Adam Schefter. Jacobs was held out of the Week 12 win over the Minnesota Vikings after suffering a minor knee contusion in the Week 11 win over the New York Giants. The 27-year-old star RB is back after a one-game absence and will be looking to start a new touchdown streak. He has 11 rushing touchdowns in 10 games played this year and entered Week 11 with touchdowns in six straight games before injuring his knee. In the Week 1 win over Detroit, Jacobs had 19 carries for 66 yards and one touchdown. Even though backup Emanuel Wilson had over 100 rushing yards and two scores last week, all signs point to Jacobs returning to his workhorse role in Detroit.

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Los Angeles Chargers offensive coordinator Greg Roman hinted that rookie first-round running back Omarion Hampton (ankle) could split backfield touches with Kimani Vidal when he returns from Injured Reserve, according to Alex Insdorf. "We'll play that one by ear. I feel really good about both of them. I'm sure you'll see some sort of 1-2 punch there," Roman said when asked about Hampton's snap numbers with Vidal also in the fold. The 22-year-old Hampton is hoping to come off IR to play in Week 13 against the division-rival Las Vegas Raiders, but nothing is official. If Hampton does return this Sunday, it sounds like he could see more of a timeshare in L.A.'s backfield, at least as the Bolts work him back into the fold for the first time since he injured his ankle in Week 5. Hampton will be a lot more volatile in fantasy football lineups if he's back on Sunday, even in a plus matchup, but eventually, he should regain lead-back duties for the Chargers by season's end.

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The Cincinnati Bengals announced on Wednesday that they officially activated quarterback Joe Burrow (toe) from Injured Reserve, and he will make his return on Thursday against the division-rival Baltimore Ravens on Thanksgiving Day. Burrow has finally recovered from surgery to fix a turf-toe injury that he suffered in Week 2. The 28-year-old franchise QB was very close to returning last weekend, but he was held out of the Week 12 loss to the New England Patriots. Cincy's offense will receive a big boost as they look to keep their faint playoff hopes alive. Burrow has been practicing in full and will take on a Ravens defense that has been much better of late as they have gotten healthier. He will be without receiver Tee Higgins (concussion), but All-Pro wideout Ja'Marr Chase is returning from a one-game suspension. Even with the long layoff, Burrow will be in play as at least a low-end QB1 option for fantasy managers in his return.

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Green Bay Packers wide receiver Jayden Reed (foot, shoulder) was not activated from injured reserve on Wednesday and has been ruled out for Thursday's matchup against the Detroit Lions, according to Matt Schneidman of The Athletic. Head coach Matt LaFleur refused to rule out Reed for the Thanksgiving game earlier in the week, saying "you'll find out Thursday," but the third-year wideout's return will wait at least another week. The 25-year-old practiced for the first time last Friday since suffering a broken collarbone during Green Bay's Week 2 win over the Washington Commanders. He was also limited on Monday and Tuesday this week, and should have a good chance of returning in Week 14 against the Chicago Bears.

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Tampa Bay Buccaneers offensive coordinator Josh Grizzard compared the workload for running back Bucky Irving (foot, shoulder) in his potential Week 13 return to how the team handled wide receiver Chris Godwin in his return against the Rams last week, Scott Smith of Buccaneers.com reports. Godwin was limited in Week 12, playing just 25 of 70 offensive snaps (36%). Irving has missed seven straight games after suffering injuries to both his foot and shoulder in Week 4 against the Philadelphia Eagles, but looked "fine" in practice Wednesday and is expected to play in Week 13 against the Arizona Cardinals. The second-year back will operate as part of a committee, with Sean Tucker and Rachaad White to stay involved. Irving's expected return is a great sign for his fantasy managers, but on a snap count, expectations should be tempered.

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Houston Texans quarterback C.J. Stroud (concussion) is practicing on Wednesday and continues to take steps toward being cleared from concussion protocol this week, per Aaron Wilson of KPRC 2. Stroud has missed three consecutive games since taking a shot to the head during Houston's Week 9 loss to the Denver Broncos. The third-year quarterback remained in concussion protocol to begin the week, but the Texans are hopeful that he will return in Week 13 for a big divisional matchup against the Indianapolis Colts. Stroud was playing well before going down, throwing for 318 yards in Week 8 against the 49ers, his first 300-yard game since Week 5 of last season. He would be back in play as a potential streamer in Week 13 if he is able to play.

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Arizona Cardinals running back Trey Benson (knee) was seen participating in Wednesday's practice session, according to Darren Urban of AZCardinals.com. The Cardinals opened Benson's 21-day practice window last week, and he was limited in practice every day before ultimately being ruled out for Week 12. Head coach Jonathan Gannon did not have an update on the second-year back's status for Week 13 against the Tampa Bay Buccaneers, so his chances of returning are still up in the air. The Arizona backfield continues to be a headache for fantasy managers and is also riddled with injury, as Emari Demercado (ankle) missed Week 12, and Bam Knight was on the injury report last week with an ankle injury as well. There should be more word on Benson's game status in the coming days, and he remains a solid stash for his eventual return.

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Arizona Cardinals wide receiver Marvin Harrison Jr. (appendix) was back at practice on Wednesday after missing the last two games due to appendix surgery, according to Darren Urban of AZCardinals.com. Harrison should have a good chance to return to action in Week 13 against the Tampa Bay Buccaneers, assuming everything goes well in practice this week. His status will continue to be monitored in the next two days. Michael Wilson has emerged as a fantasy stud during Harrison's absence, recording a whopping 25 receptions for 303 yards on 33 targets in the past two games. Wilson should continue to get more opportunities, which creates an interesting conversation about what Harrison's fantasy value could look like when he returns. There has been plenty of pass volume in Arizona with Jacoby Brissett at quarterback, so Harrison could still be relied on as a WR3 in Week 13.

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Philadelphia Eagles wide receiver DeVonta Smith (chest, shoulder) is missing a second straight day of practice on Wednesday with chest and shoulder injuries, according to Jeff Neiburg of the Philadelphia Inquirer. Smith played 95% of the offensive snaps in the Week 12 loss to the Dallas Cowboys on Sunday and caught six of his 11 targets for 89 yards in a busy day, but he's now in danger of sitting out on a short week this Friday against the Chicago Bears. The 27-year-old will need to get back on the practice field on Thursday to have a shot at playing in Week 13. If Smith is inactive or limited at all this week, A.J. Brown figures to be peppered with targets. Tight end Dallas Goedert would also have a much higher fantasy ceiling. Jahan Dotson would most likely operate as the team's WR2.

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The Seattle Seahawks are signing free-agent running back Cam Akers to their active 53-man roster on Wednesday, sources told Jordan Schultz of FOX Sports. Akers, 26, spent time with the Minnesota Vikings this season and will now join the 8-3 Seahawks for RB depth. The Seahawks are facing the Vikings in Week 13 this Sunday. Akers appeared in only three games for Minnesota this year, carrying the ball five times for 19 yards while also completing a 32-yard pass on a trick play. The six-year NFL veteran will give Seattle some more backfield depth, with George Holani (hamstring) a candidate to land on Injured Reserve. Akers probably won't have any fantasy value as long as both Kenneth Walker III and Zach Charbonnet stay healthy.

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Tampa Bay Buccaneers head coach Todd Bowles said on Wednesday that quarterback Teddy Bridgewater will get most of the practice reps this week to prepare him in case Baker Mayfield (shoulder) is unable to play on Sunday against the visiting Arizona Cardinals, according to Greg Auman of FOX Sports. Mayfield has a chance to play in Week 13 after suffering a mild AC joint sprain in his left (non-throwing) shoulder in the Sunday night loss to the Los Angeles Rams, but nothing is certain. The 33-year-old Bridgewater went 8-for-15 passing for 62 yards after taking over for the injured Mayfield on Sunday. He'll have a much better matchup against Arizona with time to prepare this weekend if he makes his first start of the season, but Bridgewater should still be considered a low-upside QB2 streamer, at best, in superflex leagues if he gets the nod.

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Atlanta Falcons head coach Raheem Morris said on Wednesday that quarterback Michael Penix Jr. (knee) had successful surgery on his knee on Tuesday, according to D. Orlando Ledbetter of The Atlanta Journal-Constitution. Penix had full reconstructive surgery to fix a partially torn ACL in his left knee, which will keep him out for the rest of this season and possibly for the start of the 2026 season next fall. The 25-year-old second-year signal-caller is facing a nine-month recovery, which will force Atlanta to rethink its long-term plan at the QB position this offseason. This is Penix's third ACL reconstruction in his career after he had two knee surgeries in college. Kirk Cousins will start the rest of the year under center for the Falcons, but depending on how he finishes the season, the Falcons could opt out of the final two seasons of his four-year deal.

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New York Giants interim head coach Mike Kafka said that rookie quarterback Jaxson Dart (concussion) will be a full participant in practice on Wednesday, according to ESPN's Jordan Raanan. It sounds as if both Dart and Jameis Winston will take first-team reps. Raanan points out that Dart is still officially in the league's concussion protocol after missing the last two games. It's good news that the 22-year-old Ole Miss product is practicing in full, but he still needs final clearance from the concussion protocol in order to be cleared to play on Monday night against the New England Patriots. Winston nearly led the G-Men to an upset of the Detroit Lions in Week 12, but if cleared, New York is fully expected to go back to Dart to close out the season after they traded into the first round of the 2025 draft to select him. If Dart is cleared to play on Monday, he'll immediately be in play as a QB1 again in fantasy due to his dual-threat abilities under center.

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Washington Commanders head coach Dan Quinn said on Wednesday that wide receiver Terry McLaurin (quadriceps) will practice this week, according to Tashan Reed of The Athletic. McLaurin looks to have made some progress coming out of the team's bye week and could make his return on Sunday Night Football versus the Denver Broncos in Week 13. The 30-year-old's status for this week will depend on how much he can do in practice, though. Scary Terry has played in only four games in 2025 due to his quad injury, but he could return just in time for the fantasy football playoffs in several weeks. If McLaurin does make his return in Week 13, he'll be coming back to an offense that is still being run by veteran backup quarterback Marcus Mariota as Jayden Daniels recovers from a gruesome dislocated left elbow. We'll be keeping a close eye on McLaurin's practice statuses this week.

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Buffalo Bills head coach Sean McDermott said that wide receiver Keon Coleman being a healthy scratch in last Thursday night's loss to the Houston Texans was not discipline-related but was due to the short run-up to the game, according to Joe Buscaglia of The Athletic. McDermott said the Bills will "take things one day at a time" with Coleman. McDermott didn't exactly clarify if Coleman will be active for this Sunday's game against the Pittsburgh Steelers, but it would be a surprise if the second-year wideout was not back on the field after being held out the last two games. The 22-year-old was a healthy scratch in Week 11 after being late to a team meeting that Friday. Coleman has been a big disappointment for the Bills and fantasy managers in 2025, catching 32 passes for 330 yards and three touchdowns on 49 targets. He'll be pretty hard to trust as a WR4/flex play in fantasy in Week 13 if he's active.

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The Kansas City Chiefs have ruled out tight end Noah Gray (concussion) for Thursday's Thanksgiving Day game against the hosting Dallas Cowboys, according to ESPN's Adam Schefter. Gray will not have enough time to clear the league's concussion protocol on a short week. His next chance to play will come in Week 14 against the Houston Texans on Sunday, Dec. 7. Travis Kelce will continue to operate as one of quarterback Patrick Mahomes' top options in the passing game, but with Gray out on Thursday, both Robert Tonyan and Jared Wiley will have a chance to see the field more. The 26-year-old Gray has not been on the fantasy football radar in most leagues in 2025, catching 16 of his 28 targets for 132 yards and no touchdowns in 11 games played.

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