Minnesota Vikings edge rusher Jonathan Greenard (shoulder) is officially inactive for Sunday's Week 12 contest against the Green Bay Packers. He had been listed as questionable after logging a pair of limited practice sessions. The 28-year-old Florida product will ultimately miss his second consecutive game, leaving a large void within Minnesota's defensive front. After all, he had 31 tackles, two sacks, and one forced fumble through his first nine contests this year. Dallas Turner is expected to earn the start in Greenard's absence. Turner was a productive fill-in last week, amassing seven tackles and one sack.

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Detroit Lions right tackle Penei Sewell (ankle) is officially active for Sunday's Week 12 contest against the New York Giants. He had been listed as questionable after logging back-to-back limited practices. The 25-year-old will suit up for his 11th game of the 2025 season, providing key protection to Jared Goff, Jahmyr Gibbs, and David Montgomery. Sewell has allowed zero sacks this season, so his presence is quite important as the Lions look to slow down a Giants pass rush headlined by Brian Burns, who has 13 sacks.

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Detroit Lions wide receiver Isaac TeSlaa (oblique) is officially active for Sunday's Week 12 contest against the New York Giants. He had been listed as questionable after practicing in a limited capacity. The rookie has merely occupied a depth role in his first pro season, catching four of his eight targets for 65 yards and two touchdowns through 10 games. Not only has TeSlaa been operating behind standout receivers Amon-Ra St. Brown and Jameson Williams, but he's also been far less involved than Kalif Raymond. As long as those three pass catchers remain healthy, TeSlaa can be avoided in fantasy football. He should be stashed in dynasty leagues and left on waivers in redraft formats.

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NFL Network's Ian Rapoport reports that the Baltimore Ravens will consider resting quarterback Lamar Jackson every Wednesday to keep him fresh for the rest of the 2025 season. Jackson missed a few games earlier this year with a hamstring injury and has missed the last two Wednesday practices due to minor ankle and knee injuries. The 28-year-old figures to be a non-participant on Monday, too, but he should be just fine for the Thanksgiving Day game against the division-rival Cincinnati Bengals next Thursday (as long as he comes out of Week 12 without any injuries). Jackson hasn't looked the same on the ground this year, which has kept him from the elite tier of QB1 options in fantasy football. However, the two-time MVP is still a set-and-forget QB1 in fantasy football and could be primed for a bounce-back performance on Sunday against the visiting New York Jets.

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The Pittsburgh Steelers defense will be without linebacker Alex Highsmith (pectoral) for their Week 12 tilt on the road in Chicago against the Bears on Sunday. Highsmith was listed as doubtful coming into this game, and he will officially miss a second straight game. However, the 28-year-old was able to practice in a limited fashion on Thursday and Friday, which means he could return in Week 13 against the Buffalo Bills. With Highsmith out again on Sunday, Nick Herbig and rookie Jack Sawyer will see more reps at linebacker for Pittsburgh. The Steelers' defense hasn't been the lockdown unit that most people are accustomed to seeing, but they will still be in play as a low-end fantasy option this weekend, despite missing Highsmith. Through 11 weeks this year, Highsmith has 24 tackles (15 solo), 5.5 sacks, six tackles for loss, 10 QB hits, and a forced fumble in seven games.

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Cincinnati Bengals running back Samaje Perine (ankle), who was listed as doubtful for Sunday's game, is officially out in Week 12 versus the visiting New England Patriots. Perine will be missing a second straight game. The 30-year-old veteran's absence will mean more change-of-pace work for rookie Tahj Brooks behind starter Chase Brown, but it won't be enough to make Brooks a standalone option in fantasy lineups this weekend in a tough matchup. It's unclear if Perine will be ready to return on a quick turnaround next week when the team squares off against the division-rival Baltimore Ravens on Thanksgiving Day on Thursday. Perine hasn't been anything more than a deep-league PPR handcuff for those who have Brown rostered. In nine games in 2025, he has 198 rushing yards and one touchdown on 32 carries, adding seven receptions for another 30 yards.

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San Francisco 49ers wide receiver Brandon Aiyuk (knee) continues to recover from last year's ACL injury, and NFL Network's Mike Garafolo reports that Aiyuk is "close to being cleared" for a return. The receiver's 21-day practice window hasn't been opened yet, but the 49ers remain hopeful that he'll get back on the field in the near future. San Francisco's receiving corps could use the help as Jauan Jennings and Ricky Pearsall have been underwhelming, combining for 53 catches, 705 yards, and three touchdowns while managing their respective injuries. Aiyuk could become an instant WR2 or WR3 in fantasy football upon his return, but an exact timetable for his activation remains unclear. This isn't the only news story we've seen about Aiyuk this week, though. A few days ago, Dianna Russini and Michael Silver of The Athletic reported that Aiyuk and the Niners were headed for a "stunning split" after the team voided his 2026 guarantees for a failure to meet contractual obligations, creating a clear path to his release next offseason. While Russini and Silver wrote that Aiyuk has likely played his final game for the 49ers, Garafolo's report seems to clarify that he'll have a good chance to get back on the field in 2025 before the team makes a decision on his future during the offseason.

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Tennessee Titans rookie running back Kalel Mullings (ankle) was activated from Injured Reserve on Saturday and is officially active on Sunday against the visiting Seattle Seahawks in Week 12. Mullings, who was selected in the sixth round in April out of Michigan, will be playing for the first time since injuring his ankle back on Sept. 21 in the loss to the Indianapolis Colts. The 23-year-old wideout will most likely be limited to a special teams role in his return this weekend while also serving as backfield depth behind Tony Pollard and Tyjae Spears. He is not a realistic starting option in any fantasy football leagues and probably won't be for the rest of his first year in the NFL. Mullings has only played in two games in 2025 and has not seen a carry or caught a pass on offense for the Titans.

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The Cincinnati Bengals have declared RB Samaje Perine, QB Sean Clifford, WR Jermaine Burton, TE Cam Grandy, DE Cameron Sample and DE Trey Hendrickson inactive for Week 12.

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The Pittsburgh Steelers have declared QB Aaron Rodgers, LB Alex Highsmith, OG Andrus Peat, OT Broderick Jones and DT Logan Lee inactive for Week 12.

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Green Bay Packers wide receiver Dontayvion Wicks (calf) is officially active for Sunday's Week 12 contest against the Minnesota Vikings. He was listed as questionable after being a limited participant in practice. The 24-year-old should occupy a larger role with rookie receiver Matthew Golden (shoulder, wrist) ruled out for this divisional battle. Wicks has 18 catches for 181 yards through eight games this season. However, he has come on particularly strong in his last two contests, tallying 10 targets and five receptions during that span. Still, he's off the fantasy radar for now, ranking as the overall WR73 in RotoBaller's Week 12 fantasy rankings.

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Kansas City Chiefs wide receiver Xavier Worthy (ankle) is officially active on Sunday against the visiting Indianapolis Colts in Week 12, according to Matt McMullen of Chiefs.com. Worthy is dealing with an ankle injury that he suffered in practice back on Nov. 13. The Chiefs listed him as questionable this weekend, but he will be out there as the team looks to avoid falling below .500 on the season. The 22-year-old second-year wideout has taken a back seat in the offense since Rashee Rice returned from his suspension. Worthy has only found the end zone once this year, too, and it came back on Oct. 12 in the win over the Detroit Lions. Since then, Worthy has gone over 50 receiving yards once in four games. On the year, the Texas product has an uninspiring 27-281-1 line in eight games played. He missed two games earlier this season with a dislocated shoulder.

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Green Bay Packers wide receiver Savion Williams (foot) is officially active for Sunday's Week 12 contest against the Minnesota Vikings. He was listed as questionable after missing two practices this past week. With Matthew Golden (shoulder, wrist) sidelined, Williams could push to carve out a larger role behind Romeo Doubs, Christian Watson, and Dontayvion Wicks. The 24-year-old rookie has been dependable when called upon, catching all 10 of his targets for 78 yards and a touchdown through 10 games. Despite his potentially increased workload on Sunday, Williams is still lower on the depth chart and can be left on waivers in most fantasy leagues. He ranks as RotoBaller's WR99 for Week 12.

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The Chicago Bears have declared LB T.J. Edwards, OT Theo Benedet, RB Travis Homer, LB Noah Sewell, DT Jonathan Ford, QB Case Keenum and WR Jahdae Walker inactive for Week 12.

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The Tennessee Titans have declared S Kendell Brooks, OT Brandon Crenshaw-Dickson, DE C.J. Ravenell, OG Drew Moss, WR Elic Ayomanor and S Xavier Woods inactive for Week 12.

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Green Bay Packers wide receiver Matthew Golden (shoulder, wrist) is officially inactive for Sunday's Week 12 contest against the Minnesota Vikings. He was listed as questionable after being a limited participant in practice. The rookie has been disappointing during his first pro season, catching just 24 passes for 286 yards through nine games. He is also still looking for his first career touchdown. Golden's second absence in three weeks will lead to more opportunities for Dontayvion Wicks (calf) in his role behind Christian Watson and Romeo Doubs.

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New England Patriots running back Rhamondre Stevenson (toe) is officially active for Sunday's Week 12 contest against the hosting Cincinnati Bengals. Stevenson will return to the Patriots' backfield after a three-game absence due to a toe injury. With the 27-year-old out, rookie TreVeyon Henderson thrived in the team's lead-back role, scoring five total touchdowns (four rushing, one receiving) while also averaging 88 rushing yards per game. New England has been non-committal on what Stevenson's role will be upon his return. Before getting hurt, Stevenson was operating as the RB1 and had 83 carries for 279 yards and three touchdowns on the ground while adding 169 receiving yards. However, after Henderson's strong performances the last three weeks, Stevenson will likely see his role reduced. Treat him as more of a shaky RB3/flex in his return this weekend.

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Seattle Seahawks running back Kenneth Walker III (glute) is officially active for Sunday's Week 12 contest against the Tennessee Titans. He had been listed as questionable after popping up on the injury report as a limited participant this past Friday. Despite the last-minute injury scare, Walker will suit up as the Seahawks' primary back. He's coming off an impressive game against the Los Angeles Rams in which he had 16 carries for 67 rushing yards and one touchdown, plus three catches for an additional 44 receiving yards. Amid a relatively inconsistent campaign in which he has shared the workload with Zach Charbonnet, Walker finds himself as the overall RB23 in fantasy scoring this season. He has a great opportunity to strengthen his fantasy value against a Titans defense that has allowed the fifth-most fantasy points to running backs in 2025. Walker ranks as the overall RB18 in RotoBaller's Week 12 fantasy rankings.

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Pittsburgh Steelers QB Will Howard will serve as the backup quarterback to QB Mason Rudolph for Week 12's game against the Chicago Bears, as a result of QB Aaron Rodgers (wrist) having been ruled out.

Green Bay Packers running back Emanuel Wilson is expected to start Sunday's Week 12 game against the Minnesota Vikings after Josh Jacobs (knee) was ruled out for the contest. Jacobs was a game-time decision coming into this weekend, and the Packers ultimately decided to hold him out. Wilson will remain the Packers' primary running back, which is the role he occupied after Jacobs departed last Sunday's game early in the second quarter. The 26-year-old finished that game with 11 carries, 40 rushing yards, and one rushing touchdown, plus a nine-yard reception. The trip to the end zone salvaged his fantasy performance, and he'll look to contribute even more this Sunday with greater volume, more passing-down work, and perhaps more goal-line opportunities. He ranks as a fringe top-24 fantasy running back against a Vikings defense that has allowed the 10th-most rushing yards to running backs in 2025, but the 11th-fewest fantasy points to the position.

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