San Francisco 49ers quarterback Mac Jones (knee) is expected to draw his eighth start of the season in Week 10 against the Los Angeles Rams. Brock Purdy (toe) is listed as questionable after a week of limited practices, and would serve as Jones' backup if active. The last time Jones faced the Rams, he enjoyed his best game of the season, passing for 342 yards and two touchdowns with no turnovers, and did so with Ricky Pearsall (knee), Jauan Jennings (ankle, shoulder), and George Kittle out due to injury. It was an exceptional lapse for the Rams' defense, which has given up just nine passing touchdowns and has allowed only one other top-12 finish to an opposing quarterback this season. This time around, Jones will still be missing Pearsall but has Jennings and Kittle back in his arsenal. Jones projects as a mid-range QB2, making him viable in two-QB formats.

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San Francisco 49ers running back Christian McCaffrey took a while to get things going on the ground, but now has reached 100 rushing yards in two of his last three games. However, in the game between, McCaffrey put up his worst numbers of the year in a slog against the Houston Texans. On Sunday, McCaffrey again faces another tough opponent in the Los Angeles Rams. The Rams have allowed the fewest fantasy points per game to opposing running backs, the sixth-fewest rushing yards, and have yet to give up a touchdown on the ground to the position. When the teams met in Week 5, McCaffrey had just 2.6 yards per carry but logged an 8-82-1 line as a receiver. Despite the difficult matchup, McCaffrey's talent makes him a weekly contender to finish as a top-12 back, and he should be locked into fantasy lineups this weekend.

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San Francisco 49ers running back Brian Robinson Jr. had a season-high 53 rushing yards and his first touchdown of the season in Week 9 against the Giants. The production gave him his first RB2 finish of 2025. Robinson is unlikely to repeat last week's success when the 49ers host the Rams on Sunday. For one, the opportunity for Robinson to produce consistently is not there. Operating as an infrequently used change-of-pace back behind Christian McCaffrey has resulted in an average of 10 offensive snaps and 4.6 rushing attempts per game. Secondly, when Robinson does get on the field in Week 10, he will be up against a Rams defense that held him to 12 yards on five carries and offered McCaffrey 2.6 yards per carry in Week 5. Robinson projects as an RB5 and is better left on the bench in Week 10.

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San Francisco 49ers wide receiver Jauan Jennings (ankle, shoulder) carries no designation into the team's Week 10 rematch with the Los Angeles Rams. Jennings, along with Ricky Pearsall (knee) and George Kittle, missed the teams' first matchup in Week 5 due to injuries, leading to a ten-catch, 142-yard bonanza for Kendrick Bourne. Jennings himself torched Los Angeles to the tune of 11-175-3 in Week 3 last season. Since returning from his absence, Jennings has not been very productive, though he still has been a focal point of the 49ers' offense. Over the last three weeks, he had a 24.7% target share and 34.6% air yard share. The Rams will likely have their attention focused on Christian McCaffrey on Sunday, which could open things up for Jennings to take another step forward. He projects as a WR3 and can be started in most leagues in Week 10.

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San Francisco 49ers wide receiver Kendrick Bourne is in line for another start on Sunday when the team hosts the Los Angeles Rams. The last time the divisional rivals squared off, in Week 5, Bourne exploded for 142 yards on 10 catches. Bourne was pushed to the top of the pecking order in the Niners' passing attack in that game due to the injury-related absences of Ricky Pearsall (knee), Jauan Jennings (ankle, shoulder), and George Kittle. Pearsall will miss a fifth consecutive game in Week 10, but Bourne will share the field with a healthy Jennings and Kittle this time. Since both returned to action in Week 7, Bourne has registered a total of seven catches for 92 yards on eight targets. Bourne projects as a lower-end WR4 in Week 10, making him a flex candidate in deeper leagues but not a must-start by any stretch.

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San Francisco 49ers wide receiver Demarcus Robinson will be granted at least one more week as the team's third wide receiver while Ricky Pearsall (knee) sits out a fifth consecutive game. Working behind Christian McCaffrey, Jauan Jennings (ankle, shoulder), George Kittle, and Kendrick Bourne in the pass game will leave few opportunities for Robinson. In Week 5, when the 49ers and Rams met for the first time in 2025, Robinson was held to three catches for 39 yards, even though Jennings, Pearsall, and Kittle were all absent due to injury. Since Jennings and Kittle rejoined the starting lineup in Week 7, Robinson has seen a total of five targets and was held without a catch in two of San Francisco's three games. In Week 10, Robinson should not be on fantasy football rosters, let alone starting lineups.

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Seattle Seahawks wide receiver Jaxon Smith-Njigba should continue to dominate fantasy football in Week 10 against the Arizona Cardinals. Although the Cardinals are No. 11 against opposing wide receivers in fantasy, Smith-Njigba has proven himself to be matchup-proof this season. The Cardinals are the only team to hold Smith Njigba to less than 96 yards or 18.3 fantasy points this season. However, that game was played in Week 4. A lot has changed since then, and Smith-Njigba has evolved into perhaps the best wide receiver in the league at the moment. Since Week 4, Smith-Njigba has not recorded fewer than 123 receiving yards or 22 fantasy points. He is about as automatic as they come. With the Seahawks' offense reaching such a high level over the last few weeks, Smith-Njigba has a great chance to continue his stats in both categories. Nobody is going to bench Smith-Njigba while he is playing like this, but you can expect another monster game in Week 10 from the third-year man.

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Seattle Seahawks kicker Jason Myers should have plenty of chances to rack up points on Sunday against the Arizona Cardinals. Myers has always been an accurate kicker, but Seattle's ascension as an office is providing Myers with a lot of shots at field goals and extra points. Myers enters Week 10 averaging 9.75 fantasy points as a kicker. He is providing your team with legitimate low-end flex value in your kicker spot. Best of all, Myers is doing so consistently. He has reached double-digit fantasy points three times this season. The Cardinals boast a solid defense, but they will be traveling to Seattle in Week 10. The home-field advantage should help Seattle be successful offensively. Trust Myers as a high-end kicker option in Week 10 and beyond.

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Seattle Seahawks running back Zach Charbonnet has been wildly inefficient and ineffective this season. However, he remains fantasy relevant because his role at the goal line is netting touchdowns. Charbonnet will face a solid Cardinals defensive front in Week 10 as he continues to split time with fellow running back Kenneth Walker III. Either way, Charbonnet's inefficiencies make him difficult to trust as a legitimate starter for fantasy this week. Fortunately, Seattle's offense should have no issue moving the ball up and down the field against the Cardinals. Charbonnet already scored on this team in Week 4, and he should have had a second score in that game. With another four teams on bye in Week 10, you could throw Charbonnet in your flex and hope for a touchdown. He is a better bet than what you are likely able to scrape together on the waiver wire this week.

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Seattle Seahawks quarterback Sam Darnold should be a quality option at the position in Week 10 against the Arizona Cardinals. Darnold has been on a tear recently. He is coming off an impressive four-touchdown performance against the Commanders in Week 9. Darnold is comfortable in the offense, and it shows. The matchup with the Cardinals is not scary. While Arizona does boast a solid defense, Darnold already took advantage of this matchup in Week 4. The Cardinals have not seen an offense as dialed in as Seattle's yet this season. As such, Darnold has a great chance to exceed the 16.08 fantasy points he scored in Week 4. As long as wide receiver Jaxson Smith-Njigba continues to play at a high level, Darnold will succeed for fantasy. Start him as a quality QB1 in Week 10.

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Seattle Seahawks running back Kenneth Walker III has been a fantasy disappointment this season; however, Walker could deliver flex value in Week 10 against the Arizona Cardinals. Arizona has a good-but-not-great defense this season. Walker already carved them up to the tune of 110 total yards in Week 4. Walker has been held in check since then, never topping 9.6 PPR fantasy points. Still, Walker is consistently receiving double-digit opportunities. It is only a matter of time before he breaks off a big run. Seattle's offense is in a serious rhythm at the moment. They are throwing the ball extremely effectively, but they could improve on the ground. Look for Walker to have a bit of a bounce-back game this week to get the Seahawks' running game going again. If you need a flex play with upside, Walker could be your man in Week 10.

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New York Giants wide receiver Jalin Hyatt is receiving another opportunity to prove his fantasy value in Week 10 against the Chicago Bears. Yet he remains an unreliable option given his minimal production this season. Hyatt has done little with his chances, registering only three receptions for 17 yards on the year, making him essentially unplayable in fantasy leagues. The silver lining is the opponent: the Bears rank 30th against WRs, giving up a league-high 38.63 points per contest. Furthermore, Chicago has allowed 20 passing touchdowns on the season, indicating a high-scoring environment where Hyatt could benefit from a deep shot. Still, based on his season-long performance of only five targets, he is not to be started in any leagues.

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New York Giants tight end Daniel Bellinger is showing subtle signs of increased involvement in the offense, making him a speculative play in deep fantasy leagues for Week 10 against the Chicago Bears. While Bellinger is the 35th-ranked fantasy TE, averaging just 3.86 points per game, he is benefiting from rookie QB Jaxson Dart's tight end targets and the team's increased use of two-tight end sets following major receiver injuries. Bellinger's impressive 17.6 yards per reception shows an unexpected deep-threat element that could exploit the Chicago defense's weakness, as they have allowed 20 passing touchdowns on the season. Although Chicago is an average matchup against the TE position, this vulnerable defense (28.4 points allowed per game) offers a glimmer of hope that Bellinger could score a sneaky touchdown.

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New York Giants wide receiver Wan'Dale Robinson has emerged as the clear focal point of the passing attack and projects as a strong fantasy start in the Week 10 road game versus the Chicago Bears. Robinson is enjoying the best season of his career, currently ranking as the 21st fantasy WR while commanding a high volume, as evidenced by his team-leading 11 targets in Week 9. His high usage, coupled with a solid 9.97 fantasy points per game, sets him up for success against the Chicago defense, which ranks 30th against fantasy WRs, surrendering a generous 38.63 points per contest. The Bears' propensity to allow points (28.4 per game, 29th in NFL) and passing touchdowns (20 allowed) makes Robinson a high-floor, high-ceiling option this week.

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New York Giants running back Tyrone Tracy Jr. is in a precarious fantasy position entering Week 10, as he is dealing with a murky workload split and a difficult opponent. Despite the season-ending injury to Cam Skattebo, Tracy Jr. saw only five carries for 18 yards in Week 9, being out-carried by Devin Singletary (eight) as the Giants transitioned to a running back committee approach. As the 47th-ranked fantasy RB, averaging 5.56 points per game, Tracy Jr.'s outlook is dimmed by the upcoming matchup with the Chicago Bears, who, while generally a poor defense, have been tougher against the run. The Bears are the 21st-ranked fantasy defense against running backs, allowing a hefty 22.73 points per game, which does offer a glimmer of hope for a committee back. Given his diminished role and low 3.5 yards per carry average, Tracy Jr. remains a risky Flex option.

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New York Giants quarterback Jaxson Dart remains a high-floor fantasy option for the Week 10 road matchup against the Chicago Bears due to his elite rushing production, despite a limited receiving corps. Currently the 17th-ranked fantasy QB, Dart averages a solid 18.48 fantasy points per game, significantly buoyed by his impressive five rushing touchdowns on the season. This week's opponent, the Bears, presents an appealing matchup for dual-threat quarterbacks, as they are the 26th-ranked fantasy defense against QBs, allowing an average of 19.66 points per game. Furthermore, Chicago's pass defense has been susceptible, allowing an average of 237.6 passing yards and 20 passing touchdowns through eight games, confirming Dart as a strong QB1 with significant upside.

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Xavier Legette may have increased involvement in the passing game in this week's matchup against the Saints in Week 10. The Carolina WR was a non-factor last week against the Green Bay Packers, only logging one reception for 22 yards. Tetairoa McMillan was limited in Friday's practice with a hamstring injury and is questionable to start in Week 10. The rookie has been the Panthers' top receiver this season with 12.1 PPR Fantasy Points Per Game. If McMillan misses Sunday's game, Legette is likely to move up on the depth chart and become one of Bryce Young's top targets. Although Legette has not been productive for fantasy players this season, there was one notable exception: Week 7 against the Jets. In that game, Legette was the top receiver targeted as he had nine receptions for 92 yards, one receiving touchdown, and recorded 24.2 PPR fantasy points. So it is possible he could provide more fantasy production in an expanded role. Monitor McMillan's status before Sunday's game, and if he is out, consider Legette as a deeper flex play for Week 10 against the New Orleans Saints.

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Jalen Coker might be worth consideration for fantasy lineups in Week 10 against the Saints. The second-year wide receiver has not been an effective fantasy performer so far in 2025, as he has only 45 receiving yards in three games played. On Friday's injury report, though, top Carolina WR Tetairoa McMillan was listed as limited in practice due to a hamstring injury and is now questionable to start in Week 10. If McMillan is out, Coker might see an increased target share as a quality contributor in the Panthers' passing attack. The Saints have been vulnerable to WRs in the last four weeks, giving up 34.73 fantasy points against the position, which ranks 25th-most among all NFL teams. Fantasy players should monitor McMillan's status, and if he is unable to play, Coker becomes a possible flex option in Week 10. Coker did show some promise late last season and may produce quality fantasy totals in a favorable matchup.

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Ja'Tavion Sanders has barely contributed to the Panthers' passing game this season. In six games played, Sanders has 16 receptions for 116 yards while averaging 4.4 PPR Fantasy Points Per Game. Last week against the Green Bay Packers, Sanders caught his only target for five yards. Carolina will face the New Orleans Saints in Week 10, who allow 14.54 points to tight ends, ranking 19th in the league. But Sanders has not shown us any reasons to believe he can take advantage of the matchup. Tetairoa McMillan, the Panthers' top pass-catcher, was limited in Friday's practice with a hamstring injury and is questionable to start on Sunday. Although more targets would be available for other Carolina pass-catchers if McMillan does not play, the fantasy outlook for Sanders does not change much at all. He has not delivered enough results to be worthy of any consideration. Sanders is not rosterable in all formats until further notice.

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Ryan Fitzgerald is a viable fill-in option if a deeper one is needed for Week 10. In last week's game against the Green Bay Packers, the Carolina kicker nailed his only field goal attempt and was 1-for-2 on extra point attempts. The rookie kicker has recorded an average of 7.2 fantasy points this season while hitting all of his field goal attempts in four of the last five weeks. Over the last four weeks, the Saints have allowed 10 points per game to the kicker position, which ranks 28th of all teams. New Orleans has also given up an average of 27 points to opposing teams, which is tied for 24th-most in the league this season. The matchup appears to be favorable for Fitzgerald, and while he is ranked just 18th at kicker by RotoBaller for Week 10, he could provide adequate fantasy totals.

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