San Francisco 49ers quarterback Brock Purdy (toe) is a full-go at the first practice of the week on Thursday, according to head coach Kyle Shanahan. Purdy returned in Week 11 for the first time since aggravating a turf-toe injury in Week 4 and looked good, going 19-for-26 passing for 200 yards and three touchdowns in a blowout win over the Arizona Cardinals. The 25-year-old managed to avoid a setback with his toe and should be a full-go for the Monday night clash against the Carolina Panthers in Week 12. The Panthers' defense has been much-improved from a season ago and hasn't been a great matchup for opposing QBs in 2025, but Purdy should still be viewed as a midrange QB1 in fantasy football now that the Niners' offense is pretty much back to full strength for the first time all year. The one drawback to starting Purdy in fantasy lineups is that he might still be hesitant to run the ball because of his toe injury. He ran just once last week for a loss of seven yards.

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The Buffalo Bills elevated wide receiver Gabe Davis to the 53-man active roster for Thursday night's game against the Houston Texans after placing receiver Mecole Hardman (calf) on Injured Reserve, according to Ian Rapoport of NFL Network. Hardman was injured in his season debut with Buffalo in Sunday's win over the Tampa Bay Buccaneers and will now be forced to miss at least four games. The 27-year-old won't be eligible to return until Dec. 14 against the division-rival New England Patriots. Davis also made his season debut last weekend with Buffalo, catching three of his four targets for 40 yards in the 44-32 win. Veteran Curtis Samuel (elbow, neck) is also out for Thursday night, and second-year wideout Keon Coleman could be a healthy scratch for a second straight week. Meanwhile, Khalil Shakir missed practice time with a personal issue this week, and tight end Dalton Kincaid (hamstring) is out. Davis could have a bigger role in Week 12, albeit against the best defense in the NFL.

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Cincinnati Bengals quarterback Joe Flacco (shoulder) was listed as a limited practice participant for the second straight day on Thursday as he battles a right shoulder issue, per Kelsey Conway of the Cincinnati Enquirer. It's worth noting that Flacco has been playing through the shoulder injury for multiple weeks, so his status for Week 12 against the New England Patriots may not ultimately be in question. However, star Bengals quarterback Joe Burrow (toe) logged his second straight full practice on Thursday as he nears a return from the toe injury that has had him on Injured Reserve since Week 2. If Burrow is cleared to play in Week 12, that would obviously send Flacco to the bench regardless of the status of his shoulder. Flacco has largely been effective in his starts for the Bengals this season, but he struggled in Week 11 against the Pittsburgh Steelers. If Burrow remains sidelined and Flacco is pressed into action for another game, he profiles as a solid fantasy QB2 in Week 12.

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The Houston Texans have waived running back Dameon Pierce, per Jonathan M. Alexander of the Houston Chronicle. A fourth-round pick of the Texans in 2022, Pierce burst onto the scene as a rookie by rushing for 939 yards and four touchdowns on 220 carries across 13 games. However, injuries and ineffectiveness have plagued him basically ever since. Across four games this season, Pierce had logged just 26 rushing yards on 10 carries. The 25-year-old was buried behind Woody Marks, Nick Chubb, and Dare Ogunbowale on the running back depth chart in Houston and had not recorded an offensive snap since Week 5. Pierce will now search for a new home for the remainder of the 2025 season. Regardless of where he ends up, Pierce is unlikely to play a fantasy-relevant role.

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Indianapolis Colts quarterback Daniel Jones (calf) was added to the team's Thursday injury report and listed as a limited practice participant due to a calf issue. While the severity of the injury is unclear, it's never a great sign for a player to be added to the injury report in the middle of the week, and it could be an indication that Jones suffered the ailment during practice. Across 10 games this season, the 28-year-old has completed 69.9% of his pass attempts for 2,659 yards, 15 touchdowns, and seven interceptions. Jones has also been a threat with his legs, rushing for 143 yards and five scores on 40 attempts. If he's unable to play in Week 12, rookie quarterback Riley Leonard would be in line to make the start on Sunday against the Kansas City Chiefs. Should Jones be active, he profiles as a borderline fantasy QB1 against Kansas City, although a calf injury could impact his effectiveness as a runner.

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Cincinnati Bengals quarterback Joe Burrow (toe) practiced in full for the second straight day on Thursday, per ESPN's Adam Schefter. The star quarterback has been on Injured Reserve since mid-September after suffering a toe injury in Week 2. However, it appears as though Burrow is nearing a return to the field in either Week 12 against the New England Patriots or Week 13 against the Baltimore Ravens. Across 17 games in 2024, Burrow completed 70.6% of his pass attempts for 4,918 yards, 43 touchdowns, and nine interceptions. Assuming he can operate at full or near-full strength when he returns to the field, Burrow profiles as a must-start fantasy quarterback and holds league-winning upside down the stretch of the fantasy season. In the short term, Burrow's availability for Week 12 is unlikely to be determined until Friday. If he remains sidelined, veteran quarterback Joe Flacco (shoulder) would be in line to make his sixth straight start for Cincinnati.

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Baltimore Ravens wide receiver Rashod Bateman (ankle) remained out of practice on Thursday as he recovers from an ankle injury he suffered in Week 10 against the Minnesota Vikings, per Brian Wacker of The Baltimore Sun. Wacker also notes that he doesn't think Bateman will play in Week 12 against the New York Jets. Across nine games this season, the 25-year-old has hauled in 16 catches for 194 yards and two touchdowns on 31 targets. In Bateman's absence in Week 11 against the Cleveland Browns, veteran wide receiver DeAndre Hopkins saw a significant uptick in playing time. However, Hopkins recorded just one catch for 11 yards on four targets against Cleveland. Even if Bateman remains sidelined against the Jets, Zay Flowers is the only Ravens wide receiver whom fantasy managers should trust as a starter in Week 12.

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Baltimore Ravens tight end Isaiah Likely (calf) returned to practice on Thursday after being held out on Wednesday due to a calf issue, per Brian Wacker of The Baltimore Sun. It's unclear whether Likely practiced in full or in a limited capacity, but either way, his return to the field is a positive sign for his chances of playing in Week 12 against the New York Jets. Across seven games this season, the 25-year-old has hauled in 12 catches for 118 yards on 16 targets. Baltimore's crowded tight end room limits Likely's upside, as all three of Likely, Mark Andrews, and Charlie Kolar played at least 19 offensive snaps in Week 11 against the Cleveland Browns. As long as all three of the Ravens' tight ends are active, Andrews is the only one who warrants low-end fantasy starter consideration.

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Carolina Panthers wide receiver Xavier Legette (hip) is practicing on Thursday after injuring his hip late in the Week 12 overtime win over the Atlanta Falcons on Sunday, according to Joe Person of The Athletic. Head coach Dave Canales said that Legette was a full participant on Thursday, which means he should be fine to play on Monday night versus the San Francisco 49ers. The 24-year-old had one of his best performances of the year on Sunday before injuring his hip, catching four of his eight targets for 83 yards and a touchdown. It was Legette's third touchdown of the year and first since Oct. 19. The former first-rounder has been Carolina's No. 2 this year behind rookie Tetairoa McMillan, but he's been pretty inconsistent for his fantasy managers. Legette has had only two games with over 31 receiving yards. The Niners have been a top-10 matchup for opposing WRs this year, but Legette's volatility makes him a boom/bust WR4/flex in fantasy in Week 12.

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Tennessee Titans wide receiver Elic Ayomanor (hamstring) is missing his second straight practice on Thursday due to a hamstring issue, per Jim Wyatt of TennesseeTitans.com. The rookie wide receiver suffered a hamstring injury during Tennessee's Week 11 loss to the Houston Texans, and his status looks to be very much in question for the team's Week 12 matchup against the Seattle Seahawks. Tennessee also lost veteran wideout Calvin Ridley (leg) to a season-ending leg injury in Week 11. Ayomanor has recorded at least six targets in three straight games, so his absence would open up target opportunities for Titans wideouts Chimere Dike, Van Jefferson, Mason Kinsey, and James Proche II. Still, it will be tough for fantasy managers to trust any of Tennessee's unproven wide receivers against a tough Seahawks defense in Week 12.

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Chicago Bears running back D'Andre Swift (hip) was a full participant in practice on Thursday as he continues to deal with a hip injury, according to Michal Dwojak of Bears Insider. Swift was listed as limited on Wednesday with his hip injury. The 26-year-old followed a similar practice plan last week before being cleared, playing 57% of the offensive snaps, and turning 21 carries into 90 rushing yards in the Week 11 win over the Minnesota Vikings. Rookie Kyle Monangai continues to be involved behind Swift and even scored again on Sunday, but if healthy, Swift is going to remain Chicago's clear lead back. Barring a setback in practice on Friday, Swift should be cleared from the Bears' final injury report heading into Week 12's game against the visiting Pittsburgh Steelers. The matchup isn't an ideal one, but Swift's volume alone should keep him in the RB2 tier for fantasy managers.

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Green Bay Packers running back Josh Jacobs (knee) doesn't think it will take long for him to return after suffering a knee contusion in Sunday's win over the New York Giants, according to Rob Demovsky of ESPN. It's not a pain issue for Jacobs, but he'll need to get his range of motion back before he's cleared to play again. He said that he banged his knee on the second play of Sunday's game, and he didn't return because his knee swelled up fast, and he couldn't bend it. The 27-year-old did not practice on Wednesday but was seen doing individual drills on Thursday, giving him a chance to be active this Sunday against the division-rival Minnesota Vikings. Jacobs' Week 12 status is truly up in the air right now, and the Packers might play it safe and hold him out this weekend. If that happens, Emanuel Wilson will be in line for lead-back duties, with Chris Brooks serving in a change-of-pace RB2 role.

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Pittsburgh Steelers quarterback Aaron Rodgers (wrist) was out on the field for the start of Thursday's practice for individual drills, according to Brian Batko of PGSportsNow. Rodgers suffered a small fracture in his left (non-throwing) wrist in the win over the Cincinnati Bengals on Sunday, and he was held out of practice on Wednesday. ESPN's Brooke Pryor reports that the 41-year-old's wrist was in "some sort of stabilizer" during individual reps on Thursday. Rodgers will most likely be listed as limited on Thursday's final injury report, but the door remains open for him to play this weekend in Chicago against the Bears. Taking snaps under center might be the most difficult thing for Rodgers to do with his left wrist injury, so it will be interesting to see if he takes more shotgun snaps on Sunday if he's active. Against a ball-hawking Bears defense, Rodgers wouldn't be all that attractive as a low-end QB2 in fantasy if he's active. If he's ruled out, Mason Rudolph would make his first start of 2025.

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Pittsburgh Steelers running back Jaylen Warren (ankle) was back at practice on Thursday and was "moving around well" after being listed as a non-participant on Wednesday, according to Brian Batko of PGSportsNow. Warren might be listed as limited on Thursday's report, but it's a good sign for his availability after he injured his ankle on Sunday in the win over the Cincinnati Bengals. The 27-year-old downplayed his ankle injury after Sunday's contest, but it was noteworthy that he didn't re-enter the game in the fourth quarter, allowing backfield mate Kenneth Gainwell to go for season highs in catches (seven) and receiving yards (81) while scoring twice. Offensive coordinator Arthur Smith hinted that Gainwell could see more touches at Warren's expense moving forward, although that will probably be dependent on Warren's health. Warren has been Pittsburgh's clear RB1 this year, but his fantasy ceiling could be lower this weekend against Chicago if he's not 100% past his ankle injury.

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Kansas City Chiefs running back Isiah Pacheco (knee) is practicing again on Thursday after being listed as a full participant in Wednesday's session, per Matt McMullen of Chiefs.com. Pacheco hasn't played since suffering a knee injury during the Chiefs' win over the Washington Commanders in Week 8. Before getting injured, the 26-year-old led the backfield with a 56.8% snap share, recording 78 carries for 329 yards and one touchdown to go along with 11 receptions (17 targets) for 43 yards and another score as a receiver in eight games. Pacheco's status for Week 12 against the Colts will be known in the days to come, but stacking together multiple days of full practices would be a good sign for his chances to suit up.

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Kansas City Chiefs wide receiver Xavier Worthy (ankle) will practice "in some capacity" on Thursday after missing Wednesday's session, Pete Sweeney of the KCStar reports. Worthy will likely be listed as a limited participant on Thursday, but it's positive to see him return to the practice field and gives him a chance to suit up in Week 12. The 22-year-old recorded just three catches for 25 yards on five targets in the loss to Denver and hasn't found the end zone since Week 6 against the Lions, which is also his only touchdown this season. Worthy's status will be updated as the week progresses, and if the speedy wideout is able to play, he will rank as a low-end WR3 for Sunday's matchup against the Indianapolis Colts.

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Tampa Bay Buccaneers offensive coordinator Josh Grizzard said that running back Bucky Irving (foot, shoulder) won't be asked to play a full number of snaps when he is cleared to play, according to Scott Smith of Buccaneers.com. With how much time Irving has missed (out since Week 4), Grizzard described it as "unfair to immediately ask him to play 50 snaps," and that they will see how much the second-year RB can handle as he makes his way back. The 23-year-old was listed as a limited participant in practice every day in Week 11 before being ruled out again for their matchup against the Bills, and he's been present for both practices so far this week. It looks like Irving will have a shot to play in Week 12 against the Rams on Sunday Night Football, but it's also feasible that the Bucs hold him out for his seventh straight game to ensure he is fully healthy. If he doesn't play, Sean Tucker is expected to see more reps after his breakout game in Week 11, with Rachaad White staying involved as well.

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New York Giants rookie quarterback Jaxson Dart (concussion) will practice again on Thursday, and there is a chance that he could clear concussion protocol, according to Jordan Raanan of ESPN. Dart is trending in the right direction after suffering a concussion in Week 10 against the Bears, then missing New York's Week 11 matchup against the Packers. The rookie first-rounder was listed as a limited participant in Wednesday's practice, and it's to be determined what his designation will be on Thursday. The 22-year-old excelled in his seven starts this season before getting injured, completing 62.7% of his passes for 1,417 yards with 10 touchdowns and three interceptions to go with 57 carries for 317 yards and seven scores on the ground, ranking as the QB3 in points per game (23.9). His status for Week 12 against the Lions will be updated in the coming days.

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Cincinnati Bengals quarterback Joe Burrow (toe) was taking snaps from starting center Ted Karras during Thursday's practice session, according to James Rapien of BengalsTalk.com. Burrow practiced in full on Wednesday and seems to be getting close to making his return to action. Head coach Zac Taylor wouldn't commit to declaring if their starting quarterback would be ready to return on Sunday against the Patriots, but the last two days have certainly provided some optimism. The 28-year-old has been sidelined for the majority of the season after suffering a turf toe injury back in Week 2 against the Jaguars. However, fantasy managers who held onto him or added him off the waiver wire can expect his return to be within the next two games.

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Baltimore Ravens quarterback Lamar Jackson (ankle) has returned to practice on Thursday, according to Morgan Adsit of FOX Baltimore. Jackson was listed as a non-participant in Wednesday's practice due to a new ankle injury. The 28-year-old two-time MVP also missed practice with a sore knee last Wednesday before returning to practice on Thursday and playing in the Week 11 win over the Cleveland Browns. The ankle is a new injury for Jackson, but it doesn't appear to be very serious, so he should be active this Sunday for a prime matchup against the two-win New York Jets. Jackson threw four touchdown passes in Week 9 in his return from a hamstring injury that sidelined him for multiple contests, but he has thrown only one touchdown and two interceptions in his last two games, and he has not had a rushing TD since Week 1. Despite a lackluster last two weeks throwing and running the football, Jackson is a prime bounce-back candidate this Sunday against the Jets.

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