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Los Angeles Rams running back Kyren Williams has started to see his usage decline recently, and a Week 5 matchup against the San Francisco 49ers won't do him any favors as he tries to get back on track. There's no question that Williams was still a productive fantasy option last Sunday as he totaled 94 scrimmage yards. However, he did so against a subpar Colts defense while handling a season-low 16 touches and 68 percent snap share. Last week, Williams' low usage was balanced out by his high efficiency. He might not have the same fortune on Thursday night against a 49ers defense allowing the sixth-fewest fantasy points to opposing running backs in 2025. Williams' fantasy value is slipping; he's now a fringe top-24 fantasy running back for Week 5.

From RotoBaller

Los Angeles Rams running back Blake Corum has continued to see his role grow, but this increased workload might not be enough to put him on the fantasy radar against the San Francisco 49ers in Week 5. Corum played 29 percent of the snaps last week and handled a season-high 11 touches, infringing on Kyren Williams' role. Corum should continue to handle double-digit touches most weeks, but he could struggle with efficiency this week. After all, he's facing a Niners defense that has allowed the sixth-fewest fantasy points to opposing running backs in 2025. He would have some low-end RB3/flex appeal against a mediocre or subpar defense, but the 49ers are no joke. He'll have trouble moving the football during Thursday night's divisional battle.

From RotoBaller

Los Angeles Rams quarterback Matthew Stafford has plenty of momentum heading into a Week 5 clash against the San Francisco 49ers. He ranks as the overall QB12 in fantasy football this season and is coming off a spectacular outing that saw him rack up 375 yards, three touchdowns, and zero interceptions. He fared quite well in Week 4, but he did so against the Indianapolis Colts, whose defense is nothing more than average this season. He'll face a tougher test Thursday night in the form of the 49ers, who have allowed the fifth-fewest passing yards and fantasy points to opposing quarterbacks in 2025. Stafford's top-12 upside is undeniable, but he'll rank as a mid-to-high QB2 this week.

From RotoBaller

Dallas Cowboys running back Miles Sanders (ankle) did not practice on Wednesday. Sanders exited Sunday night's game with a knee/ankle injury and did not return. Through four weeks, his role has already been limited by Javonte Williams' resurgence, with Sanders managing just 28 carries for 147 yards and one touchdown. If Sanders cannot go in Week 5, rookie Jaydon Blue could see his first NFL action. Blue has been a healthy scratch to start the season, but injuries to Sanders and KaVontae Turpin (foot) may force him into a meaningful role. The Cowboys' Thursday and Friday practice reports will be key in determining Sanders' availability ahead of their matchup with the New York Jets.

From RotoBaller

Updating a previous report, Washington Commanders wide receiver Deebo Samuel Sr. (heel) did not practice on Wednesday. Samuel has been excellent in his first season with Washington, catching 22 of 27 targets for 250 scrimmage yards and three touchdowns through four games. Samuel was one of several players sidelined, so it's possible that this was simply a veteran rest day, but if his heel issue lingers into Thursday's practice, concern will grow about his Week 5 availability. The Commanders face the Los Angeles Chargers, who have allowed the fifth-fewest fantasy points to wide receivers this season. With quarterback Jayden Daniels (knee) trending toward a return and receiver Terry McLaurin (quad) still sidelined, Samuel would project as a strong WR2 option if he's active.

From RotoBaller

Tennessee Titans wide receiver Calvin Ridley (knee/elbow) did not practice on Wednesday. Ridley has struggled to start the 2025 season, catching just 10 of 24 targets for 141 yards with no touchdowns, ranking as the WR73 in PPR formats. Head coach Brian Callahan revealed Ridley was battling through an in-game injury during last week's 26-0 loss to the Houston Texans, raising further concern about his availability. If Ridley is sidelined in Week 5, rookie Elic Ayomanor is expected to see a significant uptick in usage against the Arizona Cardinals. Regardless of his injury status, Ridley's early-season struggles and difficult circumstances in the Titans offense make him a clear sit in fantasy lineups this week.

From RotoBaller

New Orleans Saints tight end Juwan Johnson (ankle) did not practice on Wednesday. Johnson is coming off his least productive game of the season in Week 4, catching just three passes for 28 yards. He now appears to be dealing with an ankle injury that he picked up during the loss against the Buffalo Bills, but he managed to play nearly 90% of the snaps. If Johnson is unable to go in Week 5, Jack Stoll would step in as the Saints' starting tight end. The matchup is not ideal, as the New York Giants have surrendered the 10th-least fantasy points to tight ends this season. If Johnson suits up, he projects as a low-end TE1 option in Week 5, but fantasy managers should keep an eye on his practice participation.

From RotoBaller

Philadelphia Eagles wide receiver A.J. Brown is not expected to be traded during this season despite recent speculation. Brown has struggled out of the gate, catching just 14 of 28 targets for 151 yards and one touchdown through four games. While his slow start has drawn attention, it hasn't stopped the Eagles from rolling to a 4-0 record, including big wins against the Chiefs, Buccaneers, and the Rams. Trade buzz began swirling after Brown posted cryptic messages on social media, but a move remains highly unlikely. His contract carries a nearly $90 million dead-cap charge, making a midseason trade virtually impossible. Brown is expected to remain in Philadelphia as part of a run-heavy offense led by Jalen Hurts and Saquon Barkley. Looking ahead to Week 5, Brown draws a tough matchup against 2024 Defensive Player of the Year, Patrick Surtain II, and the Denver Broncos. Given his early struggles and the Eagles' offensive approach, another quiet outing could be on the horizon.

From RotoBaller

Washington Commanders wide receiver Terry McLaurin (quad) could need another week or two before returning, per ESPN's Dan Graziano. McLaurin injured his quad in Week 3 and sat out the team's Week 4 loss to the Atlanta Falcons. He was also absent from Wednesday's practice ahead of the Commanders' Week 5 matchup with the Los Angeles Chargers. If McLaurin remains out, Deebo Samuel Sr. (who also missed Wednesday's practice), rookie Luke McCaffrey, and Jaylin Lane would be the primary beneficiaries in the passing game. Quarterback Jayden Daniels (knee) is trending toward a Week 5 return, but he may have to play without his top receiver. Facing a tough Chargers defense in his first game back, Daniels could be in for a down week.

From RotoBaller

Las Vegas Raiders tight end Brock Bowers (knee) was a limited participant during Wednesday's practice. Fantasy managers shouldn't be too concerned at the moment. The Raiders are just being cautious with their superstar tight end. Right now, there is no reason to believe that Bowers will miss the Week 5 matchup against the Indianapolis Colts. Last week, Bowers hauled in five of his six targets for 46 yards in the loss. The 22-year-old has been held under 50 receiving yards in each of the last three games. Hopefully, Bowers can turn it around this weekend in Indy. Fantasy managers should check back on Thursday and Friday just in case this knee injury does become an issue.

From RotoBaller

Tampa Bay Buccaneers quarterback Baker Mayfield (knee, biceps) was unable to take the practice field on Wednesday. Mayfield was limited all last week due to a right biceps injury. Now, it appears Mayfield has picked up a knee injury during last week's game against the Philadelphia Eagles. That being said, the Bucs have decided to hold Mayfield out on Wednesday. This is a bit concerning for fantasy managers, but it's probably just the Bucs being cautious with their banged up quarterback. These seem like minor issues that shouldn't cause Mayfield to miss Week 5. However, fantasy managers should check back on Thursday for another update on his status. The absence of Mayfield would likely mean Teddy Bridgewater would start against the Seattle Seahawks in Week 5.

From RotoBaller

Cleveland Browns tight end David Njoku (knee) was a limited participant during Wednesday's practice session. This shouldn't be too concerning as Njoku also opened last week's practice as limited as well. Despite that, Njoku still played in Week 4, but was held to two receptions for 11 yards. Possibly, the change at quarterback with Dillon Gabriel taking over will help Njoku's value. Fantasy managers shouldn't be too worried about the knee injury at the moment. They should continue to check back throughout the week for more updates. If Njoku sits, Harold Fannin Jr. would see increased snaps in Week 5.

From RotoBaller

San Francisco 49ers quarterback Brock Purdy (toe) has already been ruled out for the upcoming Week 5 matchup against the Los Angeles Rams. Purdy made his return to the field last Sunday and looked decent under center. Afterwards, head coach Kyle Shanahan revealed that Purdy is dealing with toe soreness, which is likely related to his turf toe injury. Regardless, there wasn't enough time for Purdy to get ready to play during this Thursday night matchup. The 25-year-old isn't even healthy enough to serve as the emergency backup. The 49ers are fearful that this toe injury could be something that lingers all season long. Fantasy managers better get a viable backup with Purdy already missing three of the first five games of the season. Mac Jones will start under center on Thursday night. Jones has looked solid under center and has some streaming value for this one.

From RotoBaller

Philadelphia Eagles tight end Dallas Goedert (knee) wasn't able to participate in practice on Wednesday. It's unclear if this is a new knee injury or the same one that kept Goedert sidelined in Week 2. Possibly, Goedert's absence was more rest related than a true knee injury. Fantasy managers should check back on Thursday and Friday to see if Goedert practices. He's coming off a two-touchdown performance in Week 4 and looked completely fine during that game. If he sits, Grant Calcaterra figures to see increased snaps this weekend against the Denver Broncos.

From RotoBaller

Tampa Bay Buccaneers QB Baker Mayfield (knee, biceps) did not practice Wednesday, Oct. 1.

Fantasy Spin: Mayfield was banged up heading into the Week 4 contest but was able to play. Despite injuries to several key player, he has managed to toss multiple touchdowns in three of the four games this season. He will face a tough test against Seattle in Week 5, but Mayfield should still be in the low-end QB1 mix.

From TheHuddle

Indianapolis Colts CB Xavien Howard informed the team that he is retiring from the NFL and later posted a statement on social media.

From TheHuddle

Tampa Bay Buccaneers WR Sterling Shepard (foot) did not participate in practice Wednesday, Oct. 1. The Buccaneers only held a walkthrough Wednesday, so this is an estimation.

Fantasy Spin: Shepard's availability for Week 5 will not be known until later in the week, so fantasy players can check on his status in a few weeks. He had a good game a few weeks ago but has been held to under 40 yards in three of the four games this season. He will see a few targets if he plays but can be avoided in fantasy leagues.

From TheHuddle

Tampa Bay Buccaneers WR Chris Godwin (ankle) fully participated in practice, Wednesday, Oct. 1. The Buccaneers only held a walkthrough Wednesday, so this is an estimation.

Fantasy Spin: Godwin made his season debut last week but was only able to catch three of his 10 targets during the game. He seems like he will be an important part of the passing game right away and should see a good amount of targets again this week. He can be considered a No. 2 or No. 3 receiver in fantasy leagues.

From TheHuddle

Arizona Cardinals running back Michael Carter told Cardinals' beat reporters on Wednesday that he will be starting at running back in Sunday's game against the Titans. Carter wasn't explicitly asked if he was going to start, but he indirectly said it when answering a question about the rollercoaster of a year he's had. There was plenty of intrigue and uncertainty around Arizona's backfield following Trey Benson (knee) surprisingly being placed on IR. Some assumed that Emari Demercado would operate as the primary back after seeing most of the snaps in Benson's absence last week against the Seahawks. But Demercado played primarily in his normal role on special teams and on pass downs as the Cardinals were in comeback mode. Carter doesn't play special teams and was inactive for the first three games, then played only four snaps last week. He operated as a lead back late last season when all the Arizona backs were hurt, and it looks like he'll get another opportunity. Carter feels like an RB that fantasy managers can pick up and then plug and play into their lineup this week as he gets a dream matchup against the lowly Titans.

From RotoBaller

Tampa Bay Buccaneers CB Jamel Dean (hip), WR Mike Evans (hamstring), DT Greg Gaines (pectoral), RB Bucky Irving (foot, shoulder), S Christian Izien (quadriceps), QB Baker Mayfield (biceps, knee), CB Benjamin Morrison (hamstring), WR Sterling Shepard (foot) and S Tyreke Smith (ankle) did not participate in practice Wednesday, Oct. 1. LB Lavonte David (knee), DE Logan Hall (groin), LB Haason Reddick (neck) and OT Tristan Wirfs (knee) were limited during practice. WR Chris Godwin (ankle), OT Charlie Heck (knee) and CB Zyon McCollum (thumb) fully participated in practice. The Buccaneers only held a walkthrough Wednesday, so the report is an estimation.

From TheHuddle