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When asked if Indianapolis Colts wide receiver Adonai Mitchell would be active for the Week 6 contest against the visiting Arizona Cardinals on Sunday, head coach Shane Steichen said, "We're working through that," according to Jake Arthur of Locked On Colts. Mitchell is currently in the dog house in Indy after making two crucial mistakes in the team's Week 4 loss to the Los Angeles Rams. Alec Pierce (concussion) missed a second straight game in last week's blowout win over the Las Vegas Raiders, but Mitchell took on a much smaller role, playing just six offensive snaps and being targeted just once. Ashton Dulin was the beneficiary of the offense with Mitchell essentially benched, and he caught two passes for 55 yards. Pierce has cleared the league's concussion protocol and will play against Arizona, so there's a chance Mitchell will be a healthy scratch. Regardless, Mitchell's arrow is pointed firmly downward right now.

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Indianapolis Colts head coach Shane Steichen said that wide receiver Alec Pierce (concussion) will play in Week 6 on Sunday against the visiting Arizona Cardinals after clearing the league's concussion protocol this week, according to Stephen Holder of ESPN. Pierce missed the team's last two games as a result of his head injury that he suffered in Week 3. The 25-year-old looked like he was close to playing in Week 5, but he was eventually ruled out after suffering a setback last Friday. With Pierce back in the fold, Adonai Mitchell could be on his way to being a healthy scratch after seeing his role dramatically reduced last Sunday following two crucial mistakes in the Week 4 loss. Pierce should settle back in as a top-three wideout for the Colts alongside Michael Pittman Jr. and Josh Downs. Before his injury, the former second-rounder had caught nine passes for 171 yards and no touchdowns in three games.

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Cleveland Browns rookie fifth-round quarterback Shedeur Sanders will serve as the backup to fellow rookie Dillon Gabriel in the Week 6 divisional clash on Sunday against the Pittsburgh Steelers, according to head coach Kevin Stefanski. Sanders began the year buried on Cleveland's QB depth chart, but he has slowly risen up the ranks after the Browns traded both Joe Flacco and Kenny Pickett. The 23-year-old showed well in training camp and the preseason and has been praised by the coaching staff for the work that he's put in, but they are going to continue to develop him at their own pace in what is looking like another rebuilding year. Gabriel will probably have a long leash under center as he heads into just his second NFL start this weekend against Pittsburgh. However, Sanders' odds of seeing action in 2025 later this year have risen dramatically after the trade of Flacco this week. He is still only deserving of being rostered in fantasy in dynasty/keeper leagues.

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Cincinnati Bengals wide receiver Ja'Marr Chase (illness) has popped up on the Week 6 injury report and will be questionable for Sunday's game against the Green Bay Packers, according to head coach Zac Taylor. Chase was under the weather and was unable to practice on Friday, per Ben Baby of ESPN. The 25-year-old's status is now worth monitoring going into Sunday's game at Lambeau Field, but in all likelihood, he will be ready to play come Sunday. As long as Chase is active, he proved last week that he remains a must-start in fantasy, even without quarterback Joe Burrow (toe). The Bengals will be debuting new QB Joe Flacco in Week 6 against the Packers. Flacco may not necessarily be an upgrade over Jake Browning under center, but he shouldn't be shy about forcing targets to Chase and Tee Higgins, the Bengals' best two pass-catchers. Chase is coming off a six-catch, 110-yard, two-touchdown performance in the Week 5 loss to the Detroit Lions.

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Jacksonville Jaguars tight end Brenton Strange (hip, quadriceps), who leads the team in catches through five weeks, is dealing with a hip and quad injury that includes a ligament tear, sources tell Jordan Schultz of FOX Sports. Strange suffered the injury in the Monday night win over the Kansas City Chiefs. Schultz said it's his understanding that Strange doesn't need surgery, but he will be out at least five weeks. It could have been worse, but Jacksonville is going to be without its top TE for a while. The 24-year-old was placed on Injured Reserve earlier this week, which means he'll be out at least four games. Strange was having a nice start to the year before his injury, catching 20 passes for 204 yards, although he hadn't found the end zone. In his absence, the Jags will look to both Hunter Long and Johnny Mundt for production at the TE position. Fantasy managers should be able to find better TE2 streamers elsewhere.

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The Carolina Panthers have listed tight end Ja'Tavion Sanders (ankle) as questionable to play in the Week 6 tilt against the visiting Dallas Cowboys on Sunday, according to The Athletic's Joe Person. Sanders was limited in Wednesday's practice, was able to practice in full on Thursday, and was then limited again on Friday. The 22-year-old is attempting to return from a high-ankle sprain that has kept him sidelined for the last two weeks. Sanders will test out his ankle during pre-game warmups on Sunday and is being treated as a game-time decision this weekend. Carolina could get both Sanders and receiver Jalen Coker (quadriceps) back, but the offense will be without running back Chuba Hubbard (calf) for a second straight week. Tommy Tremble has seen more pass-game looks at tight end with Sanders out the last couple of weeks, but if Sanders returns on Sunday, he should step right back into his TE1 in Carolina.

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The Carolina Panthers have ruled out running back Chuba Hubbard (calf) for their Week 6 contest this Sunday against the visiting Dallas Cowboys, according to Joe Person of The Athletic. It will be the second straight game that Hubbard is inactive due to a calf injury that he suffered in Week 4. Rico Dowdle burst onto the scene as Hubbard's replacement in the Week 5 win over the Miami Dolphins and was dominant with the ball in his hands, rushing for over 200 yards on the ground and a touchdown. Fantasy managers shouldn't be expecting a repeat, but the increased volume as the clear-cut RB1 in the backfield for a second straight week pretty much makes Dowdle a must-start RB2 in fantasy lineups for the second straight week in a revenge game against his former team. Hubbard's next chance to return to action will be in Week 7 against the New York Jets.

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The Carolina Panthers have listed wide receiver Jalen Coker (quadriceps) as questionable to make his 2025 debut in Week 6 against the visiting Dallas Cowboys on Sunday, according to Joe Person of The Athletic. Despite practicing in full on Wednesday and Thursday, Coker will be a game-time decision on Sunday. The 23-year-old missed the first five weeks of the season due to a pretty serious quadriceps injury that he suffered at the end of August, but he's almost fully recovered. The Panthers could ease Coker back into the fold whenever he's officially activated from Injured Reserve, but given the lack of production behind rookie Tetairoa McMillan this year, the second-year pass-catcher could quickly earn plenty of playing time in Carolina. Coker won't be a realistic starting option in fantasy if he's active this weekend, but he's deserving of a waiver-wire pickup and stash now that his 2025 debut is just around the corner.

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The Tampa Bay Buccaneers will be without wide receiver Mike Evans (hamstring) for a third straight game when they take on the San Francisco 49ers on Sunday in Week 6, according to Rick Stroud of the Tampa Bay Times. In addition to Evans being out, Tampa will also be without veteran pass-catcher Chris Godwin (leg). Evans will miss a third straight contest after straining his left hamstring in the Week 3 win over the New York Jets. The 32-year-old future Hall of Famer will need to return to practice next week if he is to have any chance at returning for a Monday night showdown against the Detroit Lions to close out Week 7 action. With both Evans and Godwin out this weekend, rookie first-rounder Emeka Egbuka, Sterling Shepard, and Tez Johnson should start in three-wide sets. Tight end Cade Otton will also have a higher ceiling. Shepard is worth looking at as a flex play in deeper leagues with more targets coming his way.

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Green Bay Packers wide receiver Christian Watson (knee) will not play in Week 6 against the Cincinnati Bengals, but head coach Matt LaFleur said he's looked "pretty damn good" and that he's "excited for when that day comes," according to Rob Demovsky of ESPN. The Packers aren't going to rush Watson back after he tore his ACL in the Week 18 regular-season finale last year. The 26-year-old returned to practice for the first time this year on Wednesday and has been limited this week. Depending on how much Watson is able to do next week in practice, it's possible he'll officially be activated from the Physically Unable to Perform list to make his debut in Week 7 versus the Arizona Cardinals. Watson has had trouble staying healthy early in his NFL career and will be returning to a crowded receiving corps, but he has the potential to be an explosive deep threat for the Packers' offense when everything is right.

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Tampa Bay Buccaneers running back Bucky Irving (foot, shoulder) will miss a second straight game this Sunday in Week 6 against the San Francisco 49ers, according to Rick Stroud of the Tampa Bay Times. Irving is dealing with a left-foot sprain and a shoulder subluxation and will not be available for fantasy managers for the second straight week after missing all three practices this week. The 23-year-old's shoulder injury is the bigger concern, and it remains to be seen if he'll be able to make enough progress to have a chance to return in Week 7 when the team takes on the Detroit Lions on the road on Monday Night Football. Rachaad White wasn't all that efficient as a runner in last week's win over the Seattle Seahawks, but he saw an uptick in volume and found the end zone twice as the RB1 for the Bucs with Irving out. For the additional volume alone, White is a plug-and-play RB2 again this week in fantasy.

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Arizona Cardinals head coach Jonathan Gannon said that quarterback Kyler Murray (foot) will practice on Friday, according to Dani Sureck of AZCardinals.com. Murray injured his foot in the Week 5 loss to the Tennessee Titans in the second half, but he was able to return and finish out the game. The 28-year-old then missed the first two practices of the week on Wednesday and Thursday, putting his availability in doubt for this Sunday's game on the road against the Indianapolis Colts. Murray has a shot to play in Week 6 after returning to practice on Friday, but he could draw a questionable tag for Sunday's contest. Whether he plays this weekend will depend on how he looks the next couple days. Murray has been pretty mediocre through the first five weeks of the 2025 season, but Arizona's offense would lose a lot of explosiveness if backup Jacoby Brissett were forced to start against Indy.

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Tampa Bay Buccaneers wide receiver Chris Godwin (leg) is not expected to play in the Week 6 game against the San Francisco 49ers after he missed practice all week. Godwin's fibula injury is in a different area than the fracture he suffered when he dislocated his ankle last October. Right now, he will be week-to-week, depending on how he progresses, according to Rick Stroud of the Tampa Bay Times. The Bucs have no plans to place Godwin on Injured Reserve at this time, according to sources. Godwin made his 2025 debut in Week 4, but now he's injured again and could miss multiple games. Mike Evans (hamstring) is going to miss another game, too, leaving rookie first-rounder Emeka Egbuka and Sterling Shepard as the team's top two wideouts. Tez Johnson should also have an elevated role, and tight end Cade Otton figures to draw more looks in the passing game.

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Baltimore Ravens quarterback Lamar Jackson (hamstring) is not practicing on Friday and will miss his second straight game in Week 6 against the Los Angeles Rams, according to Jeff Zrebiec of The Athletic. Jackson has not practiced since tweaking his hamstring in the Week 4 loss to the Kansas City Chiefs, and he'll miss his second straight game. The Ravens are on their bye in Week 7, so fantasy managers can only hope that the 28-year-old will be ready to go in Week 8 for a game against the Chicago Bears. Backup Cooper Rush will make a second straight start after looking bad in the blowout loss to the Houston Texans in Week 5. Baltimore will face another capable defense in the Rams, too, so fantasy managers must once again downgrade all of the Ravens' offensive skill players. Rush went 14-for-20 for 179 yards, no touchdowns and three interceptions last Sunday.

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Carolina Panthers running back Chuba Hubbard (calf) was tagged with yet another DNP for the team's final practice ahead of their Week 6 home meeting with the Dallas Cowboys. Hubbard hasn't practiced since Carolina's loss to New England in Week 4, due to a calf injury he sustained in the week leading up to the game. While it has yet to be confirmed, the Oklahoma State product is all but set to miss another contest, with backfield mate Rico Dowdle operating in his stead. Dowdle, who broke out for 234 total yards and a touchdown as the solo act last weekend, will get a smash spot in a revenge matchup against his former team. The Panthers noted that Hubbard wasn't a candidate for IR, but it's unclear precisely when he'll return to in-game action. Dowdle will be a solid RB2 in his absence.

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Baltimore Ravens quarterback Cooper Rush is in line to make a second straight start this Sunday in Week 6 against the Los Angeles Rams with Lamar Jackson (hamstring) set to miss a second straight game this weekend, according to Adam Schefter of ESPN. Jackson has not practiced at all since injuring his hamstring in the Week 4 loss to the Kansas City Chiefs. The Ravens have their bye coming up in Week 7, so the next time that Jackson will be able to play will be for a Week 8 contest against the Chicago Bears. Fantasy managers won't be waiting in line to use Rush as a QB2 in superflex leagues against a decent Rams defense after his performance in the blowout loss to the Houston Texans last Sunday. Rush threw for 179 yards on 20 pass attempts with no touchdowns and three interceptions. Mac Jones lit up L.A.'s defense last week, but we wouldn't bet on Rush doing the same this weekend.

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Miami Dolphins wide receiver Malik Washington will again look to fill the void left by teammate Tyreek Hill when his team squares off with the visiting Los Angeles Chargers in Week 6. Washington hauled in 4-of-5 passes in Miami's loss to the Panthers last Sunday, gaining no yards. Despite him falling second amongst the team's wideouts regarding targets, teammate Nick Westbrook-Ikhine saw seven more snaps (39) running behind wide receiver Jaylen Waddle as the WR2. Westbrook-Ikhine also did not gain any yards, nor did he see a target. While he's the more imposing red zone option, Washington should continue to see manufactured looks close to the line of scrimmage, and is a marginally more explosive athlete. He's a low-end flex asset for now.

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Arizona Cardinals head coach Jonathan Gannon reported on Thursday that running back Emari Demercado will not be punished for costing the team a touchdown in their loss to the Tennessee Titans in Week 5. "It's the best thing for the team," said Gannon. Demercado egregiously lost a handle on the football last weekend as he pulled up early before crossing the goal line on a breakaway run. However, it doesn't appear that the head coach will dock him playing time, despite his visible frustration on the sideline following the blunder. In somewhat of a surprise, backfield mate Michael Carter seized the team's primary rushing role following Trey Benson's (knee) injury, and that should be the case again in Week 6. Demercado will operate on third downs and as a change-of-pace option.

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Cleveland Browns tight end coach Christian Jones gave a glowing review when asked about rookie tight end Harold Fannin Jr. "He attacks every play," said Jones. "The sky's the limit. The game will open itself up for him." A third-round pick of the team in April, Fannin Jr. has wasted no time impacting the field, essentially working as a 1B option to veteran teammate David Njoku right out of the gates. Njoku has the rookie bested in snaps by a fair margin (297-255). However, Fannin Jr. has notched just two fewer targets (28) and one more reception (21). For the time being, Njoku still owns this room. With that said, it only appears to be a matter of time before the 21-year-old overtakes him. That may not occur in 2025, but Fannin Jr. is a clear trade-for target in dynasty and keeper formats while his price tag is cheap.

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Tampa Bay Buccaneers wide receiver Sterling Shepard is slated to see an uptick in volume this weekend when his team takes on the San Francisco 49ers at home. The 32-year-old will operate as Tampa Bay's second wideout in Week 6 with the news that teammate Chris Godwin (fibula) will miss the contest with a fibula injury. Veteran Mike Evans is also trending toward another missed outing, so it will be Shepard and rookie Emeka Egbuka running in two-wide-receiver sets. Tampa Bay has been pretty balanced this season (54.2% pass rate), but a consolidated target share should keep Shepard in the conversation of a solid WR3 with upside for his meeting with the 49ers. First-year pro Tez Johnson will work as the team's third wideout.

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