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The San Francisco 49ers will turn to quarterback Mac Jones in Week 2 as they face the New Orleans Saints, with Brock Purdy sidelined for the next two to five weeks. Jones, now in his fifth season, is tasked with keeping San Francisco on track while the team navigates key injuries. Expect the offense to continue leaning on Christian McCaffrey, while Ricky Pearsall and running back Brian Robinson Jr. provide additional support. Given the circumstances, the 49ers are likely to simplify the offense, prioritizing efficiency and ball control over explosive plays. While San Francisco's supporting cast provides Jones with enough weapons to stay competitive, fantasy managers should exercise caution before inserting him into lineups. For now, Jones profiles more as a wait-and-see option in deeper leagues.

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Philadelphia Eagles tight end Dallas Goedert (knee) was once again absent from practice Thursday as he continues to deal with a knee sprain suffered in Week 1 against the Cowboys. Goedert was productive before the injury, catching all seven of his targets for 44 yards, but his Week 2 availability against the Chiefs is now in jeopardy. If Goedert is sidelined, the Eagles will likely turn to a combination of Grant Calcaterra and Kylen Granson. Calcaterra logged 59% of the offensive snaps in Week 1 and would be the top candidate to step in, while Granson saw action on 27% of plays. Fantasy managers should closely monitor Goedert's status, as his absence would lower the ceiling of Philadelphia's passing game.

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Kansas City Chiefs wide receiver Xavier Worthy (shoulder) is expected to practice in some capacity on Thursday, signaling progress in his recovery from a dislocated shoulder suffered in the season opener. The injury came during a collision with teammate Travis Kelce, ending a quiet debut where the second-year wideout failed to record a catch. While surgery was initially considered, the Chiefs opted for a non-surgical route to expedite Worthy's return. Limited practice participation is a promising step, and Kansas City remains optimistic about his role moving forward. Last season, Worthy flashed his big-play potential by posting 59 receptions, 638 yards, and six touchdowns. Once fully healthy, he is expected to play a prominent role in the offense alongside Kelce and Marquise Brown.

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Baltimore Ravens tight end Mark Andrews is looking to bounce back in Week 2 after a disappointing opener against the Bills in which he recorded just one catch for five yards. While the box score was discouraging, the underlying usage tells a more positive story. Andrews logged 75% of Baltimore's offensive snaps and ran routes on 72% of Lamar Jackson's drop-backs, showing he remains a featured part of the passing game. Fantasy managers shouldn't overreact to the slow start, especially with a matchup against the Browns on deck. Cleveland allowed five receptions for 40 yards to Bengals tight ends in Week 1, and their aggressive pass rush led by Myles Garrett could force Lamar Jackson into more quick throws. That bodes well for Andrews' involvement.

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Kansas City Chiefs rookie wide receiver Jalen Royals (knee) missed another practice on Thursday, putting his availability for Sunday's Super Bowl rematch with the Eagles in serious doubt. The fourth-round pick impressed throughout the preseason and was expected to carve out an early role in the Chiefs' passing attack, but lingering knee tendinitis has delayed his NFL debut. Royals' absence leaves Kansas City relying heavily on Marquise Brown, who operated as the clear No. 1 option in Week 1. Fantasy managers should view Brown as a viable low-end WR2 or strong flex play, while veterans JuJu Smith-Schuster and Travis Kelce remain key targets for Patrick Mahomes. Until Royals is healthy enough to return, Kansas City's offense will continue to funnel through its established playmakers.

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Buffalo Bills running back James Cook is fully healthy heading into Week 2 after logging a full practice Thursday and being removed from the injury report. Cook was heavily involved in the Bills' offense during their season opener against Baltimore, racking up 44 rushing yards and a touchdown on the ground while adding five catches for 58 yards through the air. His dual-threat ability makes him a valuable piece in both real-life and fantasy football, as Josh Allen and the Bills continue to rely on his versatility. With a pivotal divisional matchup against the New York Jets on deck, Cook's role should once again feature high usage, giving him strong appeal as a locked-in RB2 with upside in PPR formats.

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Tampa Bay Buccaneers head coach Todd Bowles said wide receiver Chris Godwin (ankle) and offensive tackle Tristan Wirfs (knee) may return to play on Monday night against the Houston Texans in Week 2, although it would be "extremely unlikely," per FOX Sports' Greg Auman. Both Godwin and Wirfs are coming back from long absences and just returned to the practice field on Thursday, so fantasy managers should not be expecting Godwin to suit up for his 2025 debut on Monday. The 29-year-old suffered a season-ending dislocation of his left ankle in Week 7 of last year. It's good news that he's finally back on the practice field, but he could be fighting an uphill battle to play in Week 3 against the New York Jets, too. It's a bit early to get excited about Godwin coming back, but he should be stashed in all fantasy formats.

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The NFL is saying that it will not discipline Baltimore Ravens quarterback Lamar Jackson for his interaction with a fan in Buffalo in the team's Week 1 loss to the Bills on Sunday Night Football, according to Tom Pelissero of NFL Network. "The matter has been addressed by the club, and there is no further action from the league," a league spokesman said. Jackson was coming to the defense of a teammate who was being pushed by a fan after the Ravens scored a touchdown in a hostile environment. The 28-year-old will not face a suspension or a fine and will be active for a Week 2 divisional tilt on the road against the Cleveland Browns. The two-time MVP went 14-for-19 for 209 yards and two touchdowns in the loss to Buffalo and also had six carries for 70 rushing yards and another touchdown. The elite dual-threat QB is a must-start in all fantasy leagues against Cleveland.

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New York Giants wide receiver Wan'Dale Robinson (ankle) is back at practice on Thursday after he was listed as a non-participant on Wednesday, according to Pat Leonard of the New York Daily News. Robinson's return to practice on Thursday is a good sign that he'll be able to suit up in Week 2 against the division-rival Dallas Cowboys, but fantasy managers in deeper leagues will still want to keep a close eye on his status going into the weekend. The 24-year-old may need to upgrade to a full practice to avoid a questionable tag on Friday's final injury report for the week. In the Week 1 loss to the Washington Commanders, Robinson operated as the clear WR2 behind Malik Nabers, playing 76% of the offensive snaps while catching six of eight targets for 55 yards. The Giants' offense didn't look great, but Robinson should be in consideration as a WR4/flex in PPR leagues if he's active in Week 2.

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San Francisco 49ers general manager John Lynch said that rookie running back Jordan James (finger) will be healthy and ready to go for a Week 2 meeting in New Orleans against the Saints on Sunday, according to David Lombardi of The Athletic. James did not play in the Week 1 win over the Seattle Seahawks after breaking his finger in early August, but he was limited in Wednesday's practice and appears to be in line to make his regular-season NFL debut this weekend. It's finally a good piece of injury news for the banged-up Niners, but the 21-year-old RB figures to be no better than the RB4 for the team behind Christian McCaffrey, Brian Robinson Jr., and Isaac Guerendo. And just because James is finally healthy, it doesn't mean he'll actually be active on game day on Sunday. He is strictly a dynasty/keeper stash right now.

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Pat Leonard of the New York Daily News reports that New York Giants wide receiver Malik Nabers (back) will be a full-go in Thursday's practice after he was limited on Wednesday with an ongoing back issue that the team has been managing. Nabers was also a DNP last Friday, but he was active in the Week 1 loss to the Washington Commanders and had five catches for 71 yards on 12 targets in the season opener. Although New York's offense was stagnant in quarterback Russell Wilson's debut, it was a good sign that Nabers still had double-digit targets. The 22-year-old former first-rounder may have to manage his back issue for most of the season, but as long as he's on the field on game day, he'll be a must-start, high-end WR1 for fantasy. Nabers has a real shot to go off this weekend against a Dallas secondary that is a bit thin.

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Baltimore Ravens tight end Mark Andrews was a massive disappointment for any fantasy managers who had him in their starting lineups in Week 1. In the team's 41-40 loss to the Buffalo Bills, Andrews was targeted only once for a five-yard catch. What's even more head-scratching is that he had just one target with fellow TE Isaiah Likely (foot) inactive. Likely hasn't returned to practice this week and doesn't appear to be on track to make his 2025 debut in Week 2 this Sunday against the division-rival Cleveland Browns, but will Andrews be able to get more involved? The Browns gave up just one reception for 14 yards to Bengals tight end Mike Gesicki in their Week 1 loss, but the Ravens figure to get Andrews more involved this weekend in the passing game, especially if Likely is out again. Despite his Week 1 dud, Andrews should be considered a top-10 TE in fantasy in one of the best offenses in football.

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Dallas Cowboys wide receiver George Pickens participated in 92% (56) of the team's snaps during their loss to the Philadelphia Eagles in Week 1, the exact figure as star teammate CeeDee Lamb. The fourth-year pro didn't garner the same lofty target total Lamb drew (13), placing third on the team behind tight end Jake Ferguson, who had six (four). However, Pickens was out there for darn-near every snap and drew a long pass interference penalty. While quarterback Dak Prescott couldn't connect with his new wideout on any deep targets, there will be plenty more opportunities for the duo to do so. Furthermore, Lamb should draw extra coverage frequently, giving Pickens plenty of one-on-one opportunities on the outside. He's a WR3 with high-end WR2 upside.

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Dallas Cowboys cornerback DaRon Bland (foot) could miss a couple of weeks with a right-foot injury that he suffered in practice on Monday, sources told Todd Archer of ESPN. Bland's foot injury is unrelated to the foot issue that limited him to only seven games played in 2024, when he dealt with a stress fracture in his left foot that required surgery. He did not practice on Wednesday as the team began preparations for Week 2 against the division-rival New York Giants. With Bland now injured and cornerback Trevon Diggs still working his way back from knee surgery back in January, Dallas' secondary depth is very thin early on. Diggs played only 27 defensive snaps in the Week 1 loss to the Philadelphia Eagles, although he said he could see more action this Sunday. On 63 defensive snaps in the season opener last Thursday, Bland recorded three tackles.

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San Francisco 49ers wide receiver Ricky Pearsall is set to see an elevated workload in Sunday's meeting with the New Orleans Saints due to a myriad of injuries his team has faced. The 49ers won their opening matchup against the Seattle Seahawks, but it didn't come without some collateral damage. Tight end George Kittle (hamstring) landed on IR with a hamstring injury, while fellow wideout Jauan Jennings (shoulder) picked up a shoulder issue of his own. Jennings isn't a lock to play in Week 2, leaving Pearsall and running back Christian McCaffrey as the 49ers' top options against New Orleans. Unfortunately, quarterback Brock Purdy (shoulder, toe) isn't likely to start either, meaning Pearsall could -- and will probably -- be catching passes from former New England Patriot Mac Jones. The University of Florida product's target quality gets a downgrade if that's the case, but hopefully, his volume will help mitigate that.

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Dallas Cowboys running back Javonte Williams was far and away his team's No. 1 option out of the backfield during their Week 1 loss to the Philadelphia Eagles. It was unclear exactly how Dallas' running back touch distribution would shake out leading up to the campaign, but Williams was the unquestioned RB1 in the season opener. The former North Carolina Tar Heel out-carried teammate Miles Sanders 15-4, and out-snapped him by a hefty 47-11 margin. Sanders did break off a chunk gain, but Williams was able to punch two in across the goal line and didn't cough up a fumble like his counterpart. With rookie Jaydon Blue a healthy inactive, Williams is poised to lead this backfield for the foreseeable future. He's a decent low-end RB2/flex option.

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Tampa Bay Buccaneers wide receiver Chris Godwin (ankle) will return to the practice field for the first time on Thursday in a limited fashion. NFL Network's Ian Rapoport reported the news. Godwin is still working back from a dislocated ankle he sustained in late October of last season, aiming for a return in Week 5 when he's eligible to be reinstated off the PUP List. He'll still have some hurdles to clear, but this is a step in the right direction. Tampa Bay figures to ease the Penn State product back into a normal workload after a severe injury, and they may be even less inclined to rush the veteran with rookie teammate Emeka Egbuka filling in admirably early on in his career. As of now, he's on pace to return at his target date.

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Chicago Bears wide receiver Olamide Zaccheaus was a surprise contributor in Monday night's loss to the Minnesota Vikings. Zaccheaus was Chicago's second-leading receiver regarding receptions (four), yards (42), and targets (seven), but played far fewer snaps (30) than fellow wideouts DJ Moore (56) and Rome Odunze (63). The Bears' ground attack couldn't get much going against Minnesota's defense, but quarterback Caleb Williams' 35 passes aren't an outlandish total he's incapable of repeating. Zaccheaus' production on a weekly basis could be spotty, but Chicago doesn't exactly have a solidified third option in the passing game. The 28-year-old currently sports a top 25 targets per route run total (0.27) in the league.

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Tennessee Titans rookie wide receiver Elic Ayomanor is emerging as the clear-cut WR2 in the offense. While his Week 1 box score was modest, with only two catches for 13 yards against the Denver Broncos, the usage tells a different story. Ayomanor drew seven targets, far outpacing veteran Tyler Lockett (1) and fellow rookie Chimere Dike (1). Even with the Titans leaning heavily on 12 personnel, Ayomanor was on the field for 79% of the offensive snaps. That kind of snap share for a rookie in his first NFL game is highly encouraging. With quarterback Cam Ward expected to settle in and gain confidence as the season progresses, Ayomanor profiles as a strong buy-low candidate in fantasy. The Titans face the Los Angeles Rams in Week 2, a defense that dominated Houston in their opener, so Ayomanor isn't a recommended fantasy start just yet. However, if his role as WR2 continues, a breakout game feels inevitable.

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Atlanta Falcons wide receiver Ray-Ray McCloud III was quietly phased out of the offense in Week 1. Despite Darnell Mooney (shoulder) being a surprise inactive, McCloud caught just three of five targets for 51 yards in the Falcons' season-opening loss to the Tampa Bay Buccaneers. McCloud logged 72% of the snaps, which was a noticeable dip from his 86% snap share in 2024. He operated as the WR3 behind Drake London and second-year receiver Casey Washington, signaling a reduced role in the passing attack. With Mooney expected back soon, McCloud's usage could shrink even further. From a fantasy perspective, McCloud doesn't warrant a roster spot, even in deeper formats. Unless he delivers a surprise spike in production, he should remain on the free-agent market.

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