Per the team, San Francisco 49ers running back Christian McCaffrey (back, illness) will be active for Week 15's home matchup with the Tennessee Titans. Fresh off a bye week, the fantasy stalwart gave owners a scare after coming down with an illness. A late-week back issue offered no solace, but it appears that McCaffrey will be out there despite just one full practice this week. Fantasy managers can exhibit no worries slotting him into their lineups, as it doesn't appear he's in any danger of playing less than his typical allotment of snaps. McCaffrey is an elite RB1 option, and, officially, RotoBaller's PPR RB1 in this week's rankings.

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Washington Commanders wide receiver Noah Brown (ribs) has been ruled out for the remainder of his team's Week 15 matchup against the New York Giants due to a rib injury. Brown suffered a back injury earlier in the game that he was able to return from, but his day is now done due to a rib ailment. The 29-year-old recorded one catch for 28 yards on one target before exiting the game. It's been an injury-marred 2025 for Brown, as he's appeared in just four games for Washington this season. Without him, Commanders wideouts Jaylin Lane and Treylon Burks could both see more playing time alongside star wide receivers Terry McLaurin and Deebo Samuel Sr.

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Cincinnati Bengals tight end Noah Fant (ankle) is questionable to return to his team's Week 15 matchup against the Baltimore Ravens with an ankle injury. The 28-year-old did not record a target or reception before exiting the game. Fant entered Week 15 with 33 receptions for 283 yards and three touchdowns on 39 targets across 12 games this season. If he is unable to return in Week 15, Bengals tight ends Mike Gesicki, Drew Sample, and Tanner Hudson could all see increased playing time. Gesicki has worked as the team's lead receiving tight end in recent weeks, earning 16 targets over his last three games heading into Week 15.

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Houston Texans rookie running back Woody Marks (ankle) is questionable to return to his team's Week 15 matchup against the Arizona Cardinals due to an ankle injury. Marks recorded seven carries for 30 yards and one reception for eight yards before exiting the game. Houston entered the week already without veteran Nick Chubb (ribs), so the team's running back depth is being challenged in Week 15. If Marks is unable to return, Dare Ogunbowale and Jawhar Jordan would likely see the majority of Houston's backfield snaps for the remainder of the game against Arizona. Ogunbowale and Jordan entered the week with just four combined carries on the season.

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The Washington Commanders deemed wide receiver Noah Brown (back) questionable to return to their Week 15 game against the New York Giants. The 29-year-old receiver has been used sparingly this season, but did connect with backup quarterback Marcus Mariota for a 28-yard gain on Sunday. Fellow receiver Luke McCaffrey (collarbone) remains on injured reserve, opening the door for midseason addition Treylon Burks to step into a larger role. For fantasy purposes, Brown is already in a depth role that doesn't warrant a roster spot in the majority of formats.

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The Kansas City Chiefs said wide receiver Xavier Worthy (head) is being evaluated for a possible concussion during Sunday's game against the Los Angeles Chargers. The second-year receiver did not have a catch on one target at the time of his exit. Already on the verge of missing the playoffs, the defending AFC Champions likely will have to run the table to keep their slim odds alive. If Worthy were to miss time, the Chiefs likely would lean into a familiar cast of characters, including JuJu Smith-Schuster, Marquise Brown, and Tyquan Thornton behind No. 1 receiver Rashee Rice.

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The Arizona Cardinals said running back Bam Knight (ankle) is questionable to return to Sunday's game against the Houston Texans after departing due to an ankle injury. The fourth-year pro was carted off, just the latest in a brutal season for the Cardinals. Quarterback Kyler Murray (foot), running back James Conner (foot), and running back Trey Benson (knee) are already out for the season, while 2024 first-round pick Marvin Harrison Jr. (heel) is out today for the fourth time in five weeks. If Knight is unable to return Sunday, the Cards likely will lean on the tandem of Michael Carter and Emari Demercado (ankle), the latter of whom was questionable for the game but is active.

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In a surprise development, Chicago Bears wide receiver Rome Odunze (foot) has been ruled out for Sunday's game against the Cleveland Browns after originally being active, according to Ian Rapoport of NFL Network. The second-year receiver was given the all-clear to play on Sunday, but re-aggravated the injury before the game and won't play at all. It was an unfortunate development for any manager who started Odunze, as the news arrived just minutes before kickoff without hardly any notice to make a lineup change. Odunze came into Week 15 ranked as the No. 29 overall PPR receiver with 44 catches for 661 yards and six touchdowns, but managers will have to hope for good news in the next couple of days about his status for Week 16 against Green Bay.

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Houston Texans tight end Harrison Bryant (neck, shoulder) was activated from Injured Reserve this week and is officially active for Sunday's game against the visiting Arizona Cardinals in Week 15. Bryant will return after missing four games on IR with neck and shoulder injuries. The 27-year-old isn't a realistic fantasy option at the tight end position in his return as a backup behind Dalton Schultz. Before getting hurt, Bryant had only two receptions on six targets for seven yards in his first eight games with the Texans in 2025. He will be battling for TE2 duties the rest of the season alongside Cade Stover. If anything were to happen to Schultz, Bryant would be an option off the waiver wire as a TE2 streamer.

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The Los Angeles Rams plan to prioritize a long-term extension for superstar wide receiver Puka Nacua, according to NFL.com's Ian Rapoport. The Rams will reportedly try to make Nacua one of the highest-paid wide receivers in the NFL during the upcoming offseason. The BYU product is in the middle of his third season and has been dominant every year, establishing himself as one of the best young receivers in football. As a non-first-round pick, Nacua is only under team control for four years after being drafted, which means his contract is currently set to expire after the 2026 campaign. An extension would give the Rams long-term stability at the wide receiver position with Davante Adams, 32, more of a short-term option. Fantasy managers would appreciate the consistency, too, as Nacua was the WR4 in PPR leagues as a rookie and is the overall WR2 so far this year.

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Pittsburgh Steelers tight end Darnell Washington (concussion) has been cleared from the league's concussion protocol and has been upgraded to active for the Monday night contest against the visiting Miami Dolphins to close out Week 15 action, according to director of communications Burt Lauten. Washington was initially listed as questionable on the team's final injury report on Saturday, but he has since been cleared by an independent neurologist and will play against Miami. The 6-foot-7, 264-pounder should be treated as TE3 in fantasy despite his growing role in recent weeks. Washington has caught five of his seven targets for 79 yards in the last three games, but having to contend for targets with fellow TEs Pat Freiermuth and Jonnu Smith every week makes him too hard to trust as a starter in fantasy.

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Baltimore Ravens wide receiver Rashod Bateman (ankle) is officially inactive on Sunday against the division-rival Cincinnati Bengals. Bateman was a mid-week addition to the Ravens' Week 15 injury report and will now sit out a crucial divisional clash this weekend. The 26-year-old had the best year of his NFL career in 2024, but he has not continued that momentum into 2025, as he's caught just 18 passes for 217 yards and two touchdowns on 35 targets through 11 games this year. His absence against a porous Bengals defense will create more opportunities for veteran DeAndre Hopkins, who won't be a terrible sleeper choice as a WR4/flex in Week 15. Bateman was limited in Thursday's practice before sitting out on Friday. It remains to be seen if he'll be ready to return in Week 16 against the New England Patriots. He is currently rostered in only 14% of Yahoo leagues.

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Chicago Bears QB Case Keenum is serving as the team's No. 2 quarterback for Week 15's game against the New York Giants, since QB Tyson Bagent (illness) has been ruled out.

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Buffalo Bills wide receiver Joshua Palmer (ankle) is officially active for the Week 15 game on Sunday in New England against the division-rival Patriots. With Palmer returning to action, Gabe Davis will be a healthy scratch for Buffalo. The 26-year-old Palmer will return to the WR rotation after missing the team's last two games. He'll provide a deep threat for quarterback Josh Allen, but fantasy managers should be looking elsewhere for a flex play this weekend. Palmer is unlikely to see much playing time behind Khalil Shakir, Keon Coleman, Tyrell Shavers, and Brandin Cooks. Tight ends Dalton Kincaid and Dawson Knox will probably be more involved as well against a very capable Patriots defense. Palmer just hasn't made much noise at all in his first year in Buffalo in 2025, catching 18 of his 29 targets for 272 yards and zero touchdowns.

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Buffalo Bills linebacker Terrel Bernard (elbow) is officially inactive this Sunday for a divisional matchup against the hosting New England Patriots. Bernard was listed as questionable for this weekend, but he will end up missing a third straight game due to his elbow injury. The 26-year-old's next chance to return will come in Week 16 on the road in Cleveland versus the Browns. Against the 11-2 Patriots, the Bills' defense/special teams unit is one to fade in fantasy football lineups in Week 15. With Bernard on the sidelines again on Sunday, Shaq Thompson will draw another start for the Bills at linebacker. In terms of fantasy points per game in IDP formats, Bernard ranks as the LB46 with 56 tackles (40 solo), seven tackles for loss, one interception, three pass breakups, and two fumble recoveries in 10 starts.

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The Las Vegas Raiders have declared QB Geno Smith, CB Greedy Vance Jr., OG Jordan Meredith, WR Alex Bachman, TE Ian Thomas, DT Leki Fotu and RB Zamir White inactive for Week 15.

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The Cleveland Browns have declared DE Adin Huntington, TE David Njoku, OT Jack Conklin, CB Denzel Ward, RB Dylan Sampson, OG Wyatt Teller and OG Zak Zinter inactive for Week 15.

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The New York Giants have declared LB Kayvon Thibodeaux, QB Russell Wilson, WR Gunner Olszewski, WR Ryan Miller, OT James Hudson, P Jamie Gillan and DL Rakeem Nunez-Roches inactive for Week 15.

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As expected, Houston Texans running back Nick Chubb (ribs) will not play on Sunday against the visiting Arizona Cardinals in Week 15 due to a rib injury. Chubb injured his ribs in the Sunday night win over the Kansas City Chiefs in Week 14 and did not practice on Wednesday or Thursday. The 29-year-old returned to a limited practice on Friday, but it wasn't enough to clear him to play this weekend against Arizona. Even before his injury, Chubb had become a lackluster, low-upside RB3/flex option for fantasy managers as the No. 2 in Houston's backfield behind rookie Woody Marks. In his first year in Houston, the four-time Pro Bowler is averaging 4.1 yards per carry for 472 rushing yards and three touchdowns on 115 carries. Marks had a season-high 26 carries last week in KC and should be guaranteed another heavy workload in a great matchup against the Cardinals. Dare Ogunbowale figures to work as the RB2 behind Marks with Chubb out.

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Cleveland Browns wide receiver Cedric Tillman (concussion, ribs) is officially active on Sunday to face the hosting Chicago Bears in Week 15. Tillman managed to clear the league's concussion protocol despite not practicing on Wednesday or Thursday. The 25-year-old is also battling through a rib injury as well and might not be 100% for this weekend's game in the Windy City. Tillman could have a bigger role in Cleveland's passing attack with tight end David Njoku (knee) out, but he's still a pretty hard receiver to trust as a WR4/flex in starting fantasy lineups, even in deeper leagues. In the three games that rookie quarterback Shedeur Sanders has started, Tillman has only two catches for 28 yards. Tillman scored in the first two weeks of the season but hasn't found the end zone since, and he only has 18 receptions on the year for 197 yards on 35 targets.

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