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Indianapolis Colts wide receiver Michael Pittman Jr. has enjoyed a big bounce-back this season after struggling through his 2024 campaign. Pittman has now caught a touchdown in three of his four contests while drawing 29 targets over that span and leading the Colts' wide receivers with 234 receiving yards. Pittman should stay hot as he will host the Las Vegas Raiders in Week 5. Pittman has settled in as an every-week WR3 in fantasy and should be fired up across all leagues for his matchup against the Raiders.

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Indianapolis Colts tight end Tyler Warren has been an excellent addition to his team's offense in 2025. The rookie found the end zone for the first time in his young career on a two-yard run in the second quarter of a 27-20 loss to the Los Angeles Rams in Week 3. Warren is leading the Colts in receiving thus far, hauling in 19 passes for 263 yards through four games. He will remain a no-brainer TE1 in fantasy heading into a Week 5 home matchup against the Las Vegas Raiders.

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Indianapolis Colts running back DJ Giddens has been quiet so far in his rookie season. The rookie did not receive a touch nor draw a target while playing on just 7% of the snaps in a Week 4 loss to the Los Angeles Rams. That being said, fellow backfield mate Tyler Goodson injured his groin during the loss to the Rams and could be in line to miss some time. If that happens, Giddens would stand to benefit as the team's clear-cut RB2 and would gain some fantasy value as a handcuff to star running back Jonathan Taylor. Giddens sets up as a must-roster for those with Taylor on their fantasy squads heading into a Week 5 matchup against the Las Vegas Raiders.

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Cleveland Browns running back Dylan Sampson turned in a quiet outing in a Week 4 loss to the Detroit Lions. Sampson lost two yards on his one carry while failing to corral his lone target in the lopsided loss to the Lions. The rookie running back has barely played over the past two weeks, coinciding with Quinshon Judkins getting fully integrated into the team's offense and operating as the Browns' bellcow. Sampson still retains a small amount of fantasy value as a handcuff, but he should not be anywhere near fantasy lineups heading into a Week 5 matchup against the Minnesota Vikings in London.

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Cleveland Browns tight end Harold Fannin Jr. has cooled since a hot start to the season, having caught just five passes for 49 scoreless yards over his past two games. That being said, Fannin has remained a big part of the Cleveland offense, drawing 10 targets over that span. He might see a bump as the Browns are expected to turn to rookie Dillon Gabriel under center heading into a Week 5 matchup against the Minnesota Vikings in London. Fannin should remain rostered in all fantasy formats and is worth a look as a solid TE2 heading into Week 5.

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Cleveland Browns quarterback Shedeur Sanders has yet to take the field in a regular-season game. That being said, there have been rumors that the team is considering starting rookie Dillon Gabriel ahead of a Week 5 matchup against the Minnesota Vikings in London. If the Browns do end up making the change, it remains to be seen whether Sanders will remain the team's QB3 or if he will move up to QB2 ahead of Joe Flacco, who has struggled as Cleveland's starter this season. Either way, it would be a minor surprise if the Browns don't find a way to get Sanders on the field at some point this season, if for no other reason than to see what they have in the former Colorado Buffaloes star. Sanders should remain rostered in deep, two-quarterback dynasty formats.

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Kansas City Chiefs wide receiver Xavier Worthy returned in Week 4 and immediately made an impact against the Ravens, posting 121 scrimmage yards on seven touches in his first game back from a dislocated shoulder. While some were worried about a potential reinjury, Worthy said postgame that once he took his first hit, he knew he was "good to go." With Rashee Rice suspended, Worthy delivered the best production of any Chiefs receiver despite playing only 59% of the snaps. He now draws a Week 5 matchup on Monday night against the Jaguars, who have surrendered the 10th-most fantasy points to wideouts this season. While Kansas City is expected to ease him back into full usage, Worthy profiles as a high-risk, high-reward WR2 option for Week 5.

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Pittsburgh Steelers running back Jaylen Warren (knee) was a surprise inactive before Week 4's win over the Minnesota Vikings. In his absence, Kenneth Gainwell exploded for 134 total yards and two touchdowns. Though Gainwell's performance could earn him more volume in the coming weeks, Warren was very effective as a pass-catcher through his first three games with quarterback Aaron Rodgers and should reclaim RB1 duties when he returns. The utilization of Darnell Washington in Pittsburgh's offense seemed to open up running lanes last week, so fantasy managers should be optimistic about Warren's potential going forward. The 26-year-old will now have the bye in Week 5 to get healthy ahead of a divisional bout with the stingy Cleveland Browns defense.

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Tampa Bay Buccaneers running back Rachaad White could be in line for an expanded workload in Week 5 against the Seattle Seahawks. White has been efficient to start the 2025 season, totaling 142 yards on 32 touches, including the game-winning touchdown in Week 2 against Houston. His 4.7 yards per carry mark is a career high and currently ranks 18th in the NFL. With starter Bucky Irving dealing with an injury from the Week 4 loss to Philadelphia, White may be asked to step back into a featured role. If Irving sits, White projects as a strong RB2 option and is a must-own in all fantasy leagues.

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Minnesota Vikings running back Aaron Jones Sr. (hamstring) is targeting a return in Week 8. Jones suffered the injury late in Week 2's loss to the Falcons and was placed on injured reserve afterward. With the Vikings entering the bye in Week 6, that means Jones' next opportunity to return is in Week 8, where they face the Los Angeles Chargers on a Thursday Night. The veteran has a lengthy history of hamstring issues, and with Jordan Mason performing well during his absence, Jones may struggle to reclaim his early-season workload. Fantasy managers should prepare for a potential timeshare rather than a full return to feature-back duties.

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Buffalo Bills wide receiver Khalil Shakir has reestablished himself as the team's WR1. After a slow start, Shakir has hauled in all nine of his targets for 114 yards and two touchdowns over the past two weeks, ranking as the WR14 during that span. Despite rookie Keon Coleman's explosive Week 1 performance, Shakir has now surpassed him in nearly every statistical category. Shakir draws a favorable Week 5 matchup against the Patriots, who have allowed the 11th-most fantasy points to wideouts this season. While his usage in Joe Brady's offense remains limited, Shakir profiles as a low-end WR3 for the rest of the 2025 season.

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Houston Texans running back Joe Mixon (ankle) remains without a timetable for return after undergoing offseason surgery. He was placed on the NFI list before the season, and head coach DeMeco Ryans confirmed Monday that there are still no updates and Mixon is "nowhere close" to returning. In Mixon's absence, rookie Woody Marks has taken over the backfield, exploding for 21 touches, 119 scrimmage yards, and two touchdowns in Week 4's win over the Titans. Even if Mixon returns later this year, Houston's offensive struggles could limit the fantasy ceiling for a two-back system. Mixon should stay stashed on fantasy rosters, but expectations need to be tempered, as a repeat of his 2024 production is unlikely.

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Miami Dolphins wide receiver Tyreek Hill (knee) required only one surgery and is targeting a return before the 2026 season, according to his agent, Drew Rosenhaus. Hill suffered a gruesome knee dislocation in Week 4's win over the Jets and was immediately taken to the hospital. Rosenhaus noted that Hill avoided nerve damage, blood flow complications, and broken bones, which is a positive sign for his long-term recovery. Hill remains under contract with Miami through 2026, though trade speculation had surfaced earlier this season. With Hill sidelined, Jaylen Waddle and De'Von Achane become the clear focal points of the passing game, while Malik Washington should also see an increased role and fantasy boost.

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The Dallas Cowboys have signed veteran wide receiver Parris Campbell to their practice squad, according to NFL Network's Tom Pelissero. Campbell, a former second-round pick, has battled through multiple significant foot and knee injuries throughout his six-year career, limiting him to 1,117 receiving yards and six touchdowns across 49 games. The Cowboys are dealing with injuries at wide receiver, most notably losing CeeDee Lamb for the next few weeks and Jonathan Mingo, who was placed on injured reserve prior to the season. Campbell could be elevated from the practice squad as soon as this week, but with the Cowboys' deep receiver group, he carries little to no fantasy value at this time.

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Dynasty | Ravens quarterback Lamar Jackson is likely going to miss time with his hamstring injury. Dynasty Analysis: Most expected him to miss this week but it seems he may actually miss 2-3 weeks. If this is the case, it's a nightmare scenario for both the Ravens and dynasty managers. Baltimore is off to an awful start at 1-3 and could be forced to turn to Cooper Rush. While this won't affect his long-term dynasty value, any missed time is significant for a quarterback most have built around. Stay tuned.

From Dynasty League Fantasy

Dynasty | Jets running back Braelon Allen is likely headed to injured reserve with a sprained MCL. Dynasty Analysis: Allen was injured in Monday Night's game and represents just the latest bit of bad news for a New York team that just can't turn the corner. In fact, they've had a hard time finding the road in the past few years. Missing time will give Breece Hall a chance to showcase his talent with Allen managers hoping Hall gets moved at the trade deadline. Allen remains a hold in dynasty leagues.

From Dynasty League Fantasy

Dynasty | The Dolphins have signed wide receiver Cedrick Wilson off the Saints practice squad. Dynasty Analysis: Wilson spent the 2022 and 2023 seasons with Miami and has had some good stretches in the past. However, he'll likely slot in behind Jaylen Waddle, Malik Washington, Darren Waller and perhaps a few other pass catchers in his second stint with the team. He's really not worth a waiver add until we see him perform well consistently.

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Dynasty | The Browns have placed wide receiver Cedric Tillman on injured reserve. Dynasty Analysis: Tillman has had an awful start to the season with just 11 catches for 106 yards and two touchdowns in four games. He was expected to make a third year leap but that hasn't happened at all as it seems he has been overtaken by Isaiah Bond. He's not out for the season but will miss at least the next four weeks. It's quite possible Bond cements himself in the spot across from Jerry Jeudy, making Tillman a pretty weak hold in dynasty leagues at the moment.

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San Francisco 49ers wide receiver Ricky Pearsall (knee) was unable to practice on Tuesday due to a knee injury. This was his second straight day sitting out in practice. Fantasy managers should closely monitor his status on Wednesday as he appears to be in danger of missing their contest on Thursday evening against the Los Angeles Rams. Pearsall suffered this injury during their Week 4 loss to the Jacksonville Jaguars. Before exiting, the second-year wideout caught four of his five targets for 46 yards. During the first three games of the season, Pearsall was very productive, tallying 281 yards on 16 receptions (24 targets). With Jauan Jennings (ankle/rib) also in danger of missing this contest, the 49ers could turn to Demarcus Robinson and Kendrick Bourne to operate as the team's top wideouts.

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According to Adam Schefter of ESPN, San Francisco 49ers quarterback Brock Purdy (toe) will remain sidelined during Tuesday's practice session. Purdy was a non-participant on Monday and is now in danger of missing their contest on Thursday against the Los Angeles Rams. While Purdy missed Weeks 2 and 3 due to this toe injury, he was able to return to action in Week 4, but is dealing with setbacks. In Week 4, Purdy went 22-for-38 with 309 passing yards and a 2:2 TD:INT during their loss to the Jacksonville Jaguars. If Purdy were to remain sidelined on Wednesday, he would likely cede starting duties on Thursday evening to Mac Jones. Jones started in each of his two games he missed and averaged a solid 22.4 PPR points per game during this stretch. He would carry high-end QB2 value facing the Rams on Thursday night.

From RotoBaller