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Kansas City Chiefs running back Isiah Pacheco will face the Philadelphia Eagles in Week 2. The defending Super Bowl champions defeated the Chiefs in their last matchup, and Pacheco only had seven rushing yards on three carries. The 26-year-old will have the chance to exact some revenge, but he must first overcome the timeshare he's in with Kareem Hunt. Pacheco and Hunt had the same number of opportunities in Week 1; both handled five carries and two catches on three targets. The former ultimately finished with more total yards, but it was not an impressive performance by either back. Pacheco did manage 5.0 yards per carry when given the opportunity, so maybe he can build on that efficiency with more usage. That said, the Eagles defense was one of the toughest in the league to run against last season, and that looks to be the case again this year. Pacheco will have his work cut out for him if he wants to carve out a larger role in the Kansas City backfield. Pacheco is ranked RB35 in our RotoBaller rankings this week, making him an RB3/Flex option. He'll be a tough player to trust this week.

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Kansas City Chiefs running back Kareem Hunt will take on the Philadelphia Eagles at home this Sunday. Hunt received an identical workload to Isiah Pacheco and produced similar results. The veteran back was less efficient with his carries but picked up more receiving yards in his three opportunities. It is also important to note that Hunt appeared to be the preferred back on passing downs and short yardage situations. If this usage continues, Hunt could end up being the more fantasy-relevant player in this backfield. The Chiefs deployed Hunt in goal-line situations last season, and he was successful in that role, so it's possible that he retains that job. That said, the backfield usage was split 50/50, and it will be a difficult situation to deal with unless one player starts commanding more touches. Hunt will have to face a stout Eagles defense this week, so even if he gets more work, it could be hard to get anything going. Hunt is ranked RB48 in our RotoBaller rankings this week, making him a deeper league flex option. It might be best to wait and see how this backfield shakes out.

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San Francisco 49ers kicker Eddy Pineiro signed with the team on September 10, in the wake of the release of Jake Moody. Pineiro does not have Moody's leg strength, but he is certainly more accurate. Despite attempting twice as many field goals as Moody in his career (126 to 62), Pineiro has one fewer miss (15 to Moody's 16). San Francisco's offense has been bitten by the injury bug, including quarterback Brock Purdy (toe, shoulder), who has been ruled out for Sunday's game against the Saints. With Mac Jones at the helm, the offense's potential takes a step back, placing greater reliance on the team's kicker to put up points, however possible. Consider Pineiro a serviceable streamer for Week 2.

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Kansas City Chiefs quarterback Patrick Mahomes will take on the Philadelphia Eagles in Week 2 for a Super Bowl rematch. The last time these two teams matched up, the Eagles ended up taking home the Lombardi trophy. Jalen Hurts and the gang are coming off a Thursday night win over the Dallas Cowboys in Week 1, while the Chiefs suffered a one-possession loss to the Los Angeles Chargers on Friday. The 29-year-old had a decent performance against the Chargers, passing for 258 yards and a touchdown while adding 57 yards and a score on the ground. That said, Mahomes will have the odds stacked against him on Sunday, facing one of the best defenses in the league without two of his top offensive weapons. Rashee Rice is still serving his suspension, and Xavier Worthy is listed as doubtful for the upcoming matchup. Despite playing at Arrowhead this weekend, Mahomes and the Chiefs are home underdogs against the Eagles. The Chiefs quarterback is ranked QB11 in our RotoBaller rankings this week, making him a fringe-QB1.

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San Francisco 49ers tight end Jake Tonges was the hero of the team's Week 1 victory over the Seattle Seahawks. Tonges stepped in for an injured George Kittle (hamstring) and caught the go-ahead touchdown with just over a minute and a half left in the game. With Kittle now on injured reserve, Tonges is now the favorite to act as San Francisco's first-string tight end. Unfortunately, quarterback Brock Purdy (toe, shoulder) has been ruled out for the 49ers' next game, meaning Mac Jones will be under center when they face the Saints on Sunday. Tonges had the play of the game but saw only two other targets in Kittle's stead last week. Fantasy managers looking for streaming tight end options can probably find a more reliable option on the wire for Week 2.

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Wide receiver Kendrick Bourne signed a one-year deal with the San Francisco 49ers on September 9, returning to the team that gave him his start in the NFL in 2017. The signing was in light of injuries sustained in Week 1 by key pass catchers George Kittle (hamstring), who is now on injured reserve, and Jauan Jennings (shoulder), who is questionable for Week 2. Quarterback Brock Purdy (toe, shoulder) is also dealing with injuries and has been ruled out for Sunday's game against the Saints. Taking over the offense will be Mac Jones, who was Bourne's teammate for three years in New England, from 2021 to 2023. Bourne should not be in starting lineups but could be a bench stash in deeper leagues in case he shows renewed chemistry with Jones, given Purdy might be facing a multi-week absence.

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San Francisco 49ers wide receiver Skyy Moore stands little chance of making an impact in Week 2, despite the injury bug biting key players on offense. Even though tight end George Kittle (hamstring) is on injured reserve and wide receiver Jauan Jennings (shoulder) is questionable for Sunday's game against the Saints, veterans Marquez Valdes-Scantling and Kendrick Bourne stand in Moore's way on the depth chart. Moore played just three snaps in Week 1, and even if he does see a greater run on Sunday, the offense will be helmed by Mac Jones and not Brock Purdy (toe, shoulder), who has been ruled out. Moore's only path to fantasy relevance is in leagues that count return yards. Last week against Seattle, he fielded one kickoff and four punts, totaling 63 return yards.

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San Francisco 49ers wide receiver Marquez Valdes-Scantling saw zero targets on 15 routes run in Week 1. With George Kittle (hamstring) now on injured reserve and Jauan Jennings (shoulder) tagged as questionable for San Francisco's Week 2 matchup against the Saints, it is possible that Valdes-Scantling plays a bigger role on Sunday. Unfortunately, Brock Purdy (toe, shoulder) has been ruled out so it will be Mac Jones under center, limiting Valdes-Scantling's upside even if he does see more playing time. MVS does have the ability to stretch the field but Jones' career completion rate on passes of 20 or more air yards is a mere 30%, effectively negating that threat. If it were Purdy running the show, Valdes-Scantling would have more potential but as it is, he has little viability in Week 2.

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New York Giants kicker Graham Gano is a possible fantasy option for Week 2 against the Dallas Cowboys, depending on your league. Gano was responsible for all six of the Giants' points in Week 1, making both of his field goal attempts, including a long of 52 yards, for 8 fantasy points. This puts him in a decent position among fantasy kickers, especially since he has a 100% field goal percentage so far. His opportunities for scoring could increase against a Dallas team that gave up 11 fantasy points to kickers in Week 1 of the 2025 season. Given the Giants' offensive struggles and Gano's reliable leg, he should be considered for Week 2.

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New York Giants quarterback Jaxson Dart is not a recommended fantasy option for Week 2 against the Dallas Cowboys, as he is not expected to play. Although the rookie first-round draft pick has impressed in the preseason and is the team's QB2, head coach Brian Daboll has publicly stated that Russell Wilson will remain the starter for Sunday's game. There is some speculation that Dart could see action if Wilson struggles, but given that he has no regular-season statistics for 2025, his fantasy outlook is entirely dependent on an in-game change. Therefore, Dart should be left on the bench or waiver wire for this matchup.

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New York Giants tight end Theo Johnson is not a recommended fantasy start for Week 2 against the Dallas Cowboys. He was the TE49 in fantasy football for Week 1, securing just one of his three targets for five receiving yards and one fantasy point. This meager production, despite dominating the tight-end snaps with 46, makes him an unreliable option. Furthermore, the Cowboys' defense was a difficult matchup for tight ends in 2024, ranking second in the league by allowing only 7.66 fantasy points per game to the position. Given the tough matchup and Johnson's minimal usage and production in Week 1, he should be left on the bench in all formats.

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New York Giants running back Cam Skattebo is not a recommended fantasy start for Week 2, despite facing a favorable matchup. Skattebo was the RB58 in Week 1, with a minimal role, receiving only two carries for -3 yards and two receptions for 12 yards, totaling just 1.9 fantasy points on an 11.8% timeshare. While the Dallas Cowboys' defense was the 23rd-ranked fantasy defense against running backs in 2024 and gave up 158 rushing yards in Week 1, Skattebo is simply not seeing the volume to capitalize on the opportunity. His primary role appears to be as a depth and short-yardage option behind Tyrone Tracy Jr., which severely caps his fantasy upside.

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Despite heading to the medical tent twice, New Orleans Saints wide receiver Chris Olave led the team with 13 targets, turning them into seven receptions for 54 yards in Sunday's loss to the Arizona Cardinals. Kellen Moore's offense appeared aggressive, as quarterback Spencer Rattler attempted a career-high 46 passes in Week 1. This bodes well for the fourth-year receiver, who looks poised to become a go-to target in the pass-heavy attack. Olave should have plenty of opportunities to build chemistry with Rattler and, as long as he remains healthy, projects as a borderline WR2/WR3 this week against the San Francisco 49ers.

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New Orleans Saints wide receiver Rashid Shaheed was the team's third-most productive pass catcher in Week 1 against the Arizona Cardinals, finishing with six receptions for 33 yards on nine targets. His longest catch was just 17 yards, but his speed and explosiveness give him real big-play potential. With Kellen Moore's offense passing aggressively, Shaheed could turn his volume into a breakout performance and projects as a WR4 with upside this week against the 49ers.

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New York Giants running back Tyrone Tracy Jr. had a lackluster Week 1, but his fantasy outlook improves considerably heading into a favorable Week 2 matchup against the Dallas Cowboys. As the RB39 in Week 1, Tracy managed only 4.5 fantasy points with 24 rushing yards and 11 receiving yards, but he dominated the backfield with a 66.2% timeshare. This heavy workload, combined with the Cowboys' defensive struggles against the run, makes him an intriguing play. Dallas allowed a whopping 158 rushing yards in Week 1, the fifth-most in the NFL, and was the 23rd-ranked fantasy defense against running backs last season, giving up 22.67 fantasy points per game. Given the potential for a high-volume day, Tracy has a chance to deliver RB2 numbers.

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New Orleans Saints kicker Blake Grupe went 2-for-3 on field goals and 1-for-1 on extra points in the Week 1 loss to the Arizona Cardinals. His only miss came in the third quarter on a 37-yard attempt following a 14-play drive, while he converted from 36 and 28 yards. Grupe is a reliable kicker, but the Saints' offense, led by quarterback Spencer Rattler, may struggle to move the ball consistently. He ranks 21st among kickers on RotoBaller this week.

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New Orleans Saints quarterback Spencer Rattler went 27-of-46 for 214 yards with no touchdowns in Week 1 against the Arizona Cardinals, adding 29 rushing yards on four attempts. Despite the volume, his 4.7 yards per pass attempt was inefficient, and the 46 throws marked a career high. He faces a tough matchup at home against the San Francisco 49ers, who allowed just 150 passing yards to Sam Darnold and the Seahawks in Week 1. Rattler remains off fantasy radars for Week 2 and will need a more efficient showing to keep his starting role.

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New York Giants quarterback Russell Wilson had a tough Week 1, but he has an encouraging fantasy outlook heading into his Week 2 matchup against the Dallas Cowboys. Wilson was the QB23 in fantasy after mustering only 12.8 fantasy points against the Commanders, throwing for 168 yards and zero touchdowns. However, the Cowboys' defense allowed 24.4 fantasy points to Jalen Hurts in Week 1 and was the 32nd-ranked fantasy defense against quarterbacks last year, giving up 19.6 fantasy points per game. Wilson's 44 rushing yards in the opener, combined with the Cowboys allowing 62 rushing yards and two rushing touchdowns to Hurts, suggest he has a solid floor and a potential for a major bounce-back performance in this favorable matchup.

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New Orleans Saints running back Alvin Kamara rushed 11 times for 45 yards and one touchdown in Week 1 against the Arizona Cardinals. Surprisingly, he saw limited action in the passing game despite Spencer Rattler's career-high 46 pass attempts, catching just two targets for 12 yards. Despite this, Kamara showed he still has plenty left in the tank. He looks poised to be effective again against the San Francisco 49ers in Week 2 and should see an increased workload as a pass-catcher. He remains a high-upside RB2 this week.

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New Orleans Saints running back Kendre Miller saw limited action in Week 1 but made the most of it, rushing five times for 24 yards. The Saints ran the ball just 22 times while Spencer Rattler threw 46 passes, and Miller was on the field for only 11 offensive snaps. Rookie Devin Neal, who played seven snaps and carried the ball twice, could further limit Miller's role. While he showed flashes of explosiveness against the Cardinals, the Saints' likely pass-heavy approach means Miller can remain on waivers until his usage increases.

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