Kansas City Chiefs wide receiver Xavier Worthy (shoulder) injured his right shoulder on the team's first drive of the game in Week 1 on Friday night in Brazil against the division-rival Los Angeles Chargers and is questionable to return. Worthy was seen walking to the locker room with trainers with a towel over his head and looked pretty upset. It didn't look good, and although we don't want to speculate on the severity, it initially looked like a potential disclocation, which would obviously be a big blow for Worthy and the Chiefs. KC is already without top wideout Rashee Rice, who is opening the year on a six-game suspension, so losing Worthy for an extended amount of time would further thing the Chiefs WR corps. We'll have more on the 22-year-old after he undergoes X-rays. If he doensn't return, Marquise Brown and JuJu Smith-Schuster will see more targets, as well as Tyquan Thornton.

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Baltimore Ravens quarterback Lamar Jackson is set to face off against the only guy who stood between him and a third MVP award last season. The two-time MVP is coming off a historic season where he threw for 4,172 yards, 41 touchdowns, and only four interceptions, in addition to 915 yards and four more scores on 139 carries. The Ravens have most of the offense returning this year, and Jackson was able to put up a combined 410 yards and four touchdowns through the air, with 93 yards and a touchdown on the ground in two games against the Bills last season. It goes without saying that Jackson is a set-it-and-forget-it type of fantasy asset since he's always in play for the QB1 overall.

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Tampa Bay Buccaneers quarterback Baker Mayfield looks to build upon his unbelievable performance from 2024. Last season, Mayfield threw for 4,500 passing yards with 41 touchdowns and 16 interceptions in 17 games with the Bucs. The 30-year-old will look to keep the good times rolling against the Atlanta Falcons in Week 1. The Bucs are going to be playing shorthanded at wide receiver with both Chris Godwin (ankle) and Jalen McMillan (neck) sidelined. However, Mike Evans is one of the most consistent wideouts in the league. The Bucs also have Emeka Egbuka who figures to slot right alongside Evans as the No. 2 option. There were games last season that Mayfield didn't have Godwin or Evans and still posted QB1 numbers. Fantasy managers need to keep rolling with Mayfield who should be valued as a top 7-8 quarterback coming into the season.

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Cleveland Browns running back Dylan Sampson will make his NFL debut at home against the Cincinnati Bengals in Week 1. Sampson, a fourth-round pick in this year's NFL draft, is expected to open the season as the team's change-of-pace back behind starter Jerome Ford. The exact extent of Sampson's role is yet to be seen, but he could see plenty of work in the passing game in a contest where the Browns may have to pass frequently to keep up with a high-powered Cincinnati. Sampson checks in as a dart-throw flex option who is worth a look in deep leagues as a potential sleeper.

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Tampa Bay Buccaneers running back Bucky Irving is coming off a strong rookie campaign. Last season, Irving rushed for 1,122 yards with eight touchdowns while hauling in 47 receptions for an additional 392 yards through the air. Irving began the season as the backup, but quickly earned the starting role over Rachaad White. The 23-year-old took the starting gig and never looked back. Irving will now get the chance to be the full-time starter from Week 1. Fantasy managers should pencil him in as a RB1 for the upcoming matchup against the Atlanta Falcons. The Bucs are without Chris Godwin (ankle) and Jalen McMillan (neck) for this game. That being said, Irving should be involved plenty in the running and passing game.

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Pittsburgh Steelers kicker Chris Boswell will hope to build upon a stellar 2024 campaign when he opens the season against the New York Jets in Week 1. While there isn't expected to be an abundance of points scored in Sunday's contest, it's worth noting that New York surrendered the third-most fantasy points to opposing kickers last year. If Pittsburgh's offense struggles to finish drives in quarterback Aaron Rodgers' debut, Boswell could be called upon early and often. It's not the most appealing spot to start a kicker, but fantasy managers could do much worse than Boswell in Week 1.

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Cleveland Browns running back Jerome Ford will take on the Cincinnati Bengals at home in Week 1 of the 2025 NFL season. Ford is expected to operate as the team's workhorse back early in the season with Quinshon Judkins still unsigned and rookie Dylan Sampson ticketed for a change-of-pace role. The veteran Ford operated as the team's lead back for much of the 2024 season but only managed 565 rushing yards. Ford will take on a Bengals defense that allowed the 15th-most fantasy points per game to opposing running backs last season in Week 1, but the Browns could be playing from behind for the majority of the game against a high-powered Cincy offense. Ford checks in as a low-end RB3/flex option this weekend.

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Atlanta Falcons wide receiver Drake London logged 100 receptions and nine touchdowns last season, finishing with the fourth-most receiving yards (1,271) and the third-most targets (158) in the NFL. The fourth-year pro will take on a Tampa Bay defense on Sunday that was extremely susceptible to the pass last year, yielding the third-most pass yards per game (245.3). London had one big performance versus the Bucs last season and one clunker, but that was with Kirk Cousins under center, not Michael Penix Jr. Despite being a rookie QB, Penix Jr. did not shy away from targeting his top wideout, peppering him with eight, 13, and 18 targets over the final three games of '24, which translated to 22 catches for 352 yards and two touchdowns. With Darnell Mooney on the bad side of questionable for this contest, it could also mean a couple of extra targets for the Falcons' top wide receiver. All in all, it sets London up as a mid-range WR1 on Sunday.

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Cleveland Browns quarterback Joe Flacco will take on the Cincinnati Bengals at home to kick off the 2025 season. The Bengals struggled against the pass last season as they allowed the sixth-most fantasy points per game to opposing quarterbacks. There isn't much expectation for the Cincinnati defense to be improved heading into the upcoming 2025 campaign, giving the veteran signal-caller a plus matchup to kick off the year. That being said, Flacco did not play well in limited starts with the Indianapolis Colts last year, and it is unclear just how much the 40-year-old has left in the tank. Flacco checks in as Rotoballer's QB30 heading into Week 1 and is not a recommended starter outside of deep two-quarterback formats.

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Three-time Pro Bowl pass-rusher Za'Darius Smith signed an undisclosed one-year deal with the Philadelphia Eagles on Friday, sources told Tom Pelissero of NFL Network. Smith spent the 2024 season with the Cleveland Browns and Detroit Lions and finished with nine sacks, 35 tackles (22 solo), nine tackles for loss and 17 QB hits in 17 regular-season games (16 starts). The 32-year-old was released by the Lions in March and will now head to the NFC East to add depth to an already stout Eagles defensive line, although they could be bracing for a suspension for defensive tackle Jalen Carter after he was ejected on Thursday night for spitting on Cowboys quarterback Dak Prescott. The veteran Smith still has something left in the tank and has 69 sacks in his 10 NFL seasons. With Philly, he will probably be in a rotational role, limiting his appeal in IDP fantasy formats.

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New Orleans Saints offensive lineman Trevor Penning (toe) was unable to practice all week and has officially been ruled out for the Week 1 regular-season opener on Sunday against the Arizona Cardinals. In addition to Penning, the Saints will also be missing defensive end Chase Young (calf) and defensive tackle Alontae Taylor (groin). With Penning out to open the year, the Saints will likely roll with Dillon Radunz and Cesar Ruiz at the two guard spots in the Big Easy against the visiting Cardinals on Sunday. With Young out, the Saints will look to mix and match off the edge with players like Carl Granderson, Cameron Jordan and Chris Rumph as they look to get pressure on quarterback Kyler Murray.

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Las Vegas Raiders wide receiver Jakobi Meyers returns in 2025 after a career-best season in which he topped 1,000 yards for the first time. Despite offseason contract uncertainty, he remains a vital piece of the Raiders' passing attack, working as a trusted complement to tight end Brock Bowers. With rookies Dont'e Thornton Jr. and Jack Bech still acclimating to the NFL, Meyers' veteran presence will be leaned on heavily to stabilize the offense early in the year. The Raiders are expected to emphasize the run in Week 1, but Meyers' ability to create separation and operate effectively out of the slot makes him a strong flex option with steady volume potential.

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Washington Commanders veteran tight end Zach Ertz returns for a second season with the team, looking to remain a reliable target for young quarterback Jayden Daniels in Week 1 against the Giants. Ertz turned back the clock a bit in his age-34 season, racking up 66 catches for 654 yards and scoring seven touchdowns. His efficiency in particular rebounded significantly, with his 7.2 yards per target being the highest in a season since 2018. He served as a safety blanket for his young quarterback, consistently getting open in the red zone and on third downs. Ertz has spoken incredibly highly of Daniels since they've been together, comparing him to his former Stanford teammate, Andrew Luck. The ceiling isn't very high for Ertz in fantasy this season, but he is a safe and projectable option to pair with an upside bet at tight end late in drafts. He should be viewed as a low-end TE1 for the season opener on Sunday.

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Tennessee Titans rookie running back Kalel Mullings (ankle) popped up on the Week 1 injury report on Friday and is now questionable to make his NFL debut this Sunday on the road in Denver against the Broncos. Mullings was listed as a limited participant in Friday's practice. Mullings had been dealing with an ankle injury before and appears to have aggravated it at Friday's practice. Mid-week additions to the injury report are usually never a good sign, especially on a Friday, so the 22-year-old might have to wait until Week 2 against the Los Angeles Rams to make his NFL debut. Tyjae Spears (ankle) is starting the year on Injured Reserve, so Tennessee's backfield behind starter Tony Pollard will be very thin on Sunday if Mullings is ruled out. Julius Chestnut is lined up for a backup role behind Pollard, even if Mullings is active.

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Pittsburgh Steelers tight end Pat Freiermuth will kick off the fifth season of his career on the road against the New York Jets. Freiermuth quietly finished as a top-10 fantasy option in 2024 and should benefit from improved QB play this season, but he will now share opportunities with Pro-Bowler Jonnu Smith in what is expected to be a run-heavy offense. The Jets were stingy against opposing tight ends last year, and Sunday's contest has the lowest-projected point total of the week. As a result, Freiermuth should be avoided in all but the deepest of fantasy formats in Week 1.

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Washington Commanders wide receiver Deebo Samuel Sr. will make his team debut on Sunday against the Giants after spending six seasons in San Francisco. Samuel pairs up with Terry McLaurin as the team's wide receiver tandem, both players drafted on day two of the 2019 NFL Draft. Samuel is coming off a much-discussed down last season with the 49ers, catching 51 balls for 670 yards while adding 136 yards on 42 carries and scoring four total touchdowns. He wasn't quite as dominant after the catch as he had used to be and had easily his worst production as a runner. But it's also important to remember that he was diagnosed with pneumonia during Week 6 of the season. Before that, Samuel was still very productive lined up outside and from the slot. Now paired with a rising star at quarterback in Jayden Daniels and perhaps the next best offensive mind to utilize his strengths in Kliff Kingsbury, Samuel could be primed for a dynamic bounce-back season. His connection with Daniels has been on display all camp, and he could be relied on more if McLaurin takes a bit to get ramped up. Samuel should be viewed as a WR3 with upside for Week 1 against the Giants.

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Pittsburgh Steelers wide receiver Roman Wilson was sidelined for most of his rookie season but will look to make a name for himself in year two, starting with a road matchup against the New York Jets. Wilson should see some playing time, though his role is rather uncertain despite Pittsburgh's lack of proven pass-catchers. Between Wilson, Calvin Austin III, and Scotty Miller, someone should emerge as the team's WR2 behind DK Metcalf, but it may take time for quarterback Aaron Rodgers to build chemistry with his new weapons. Austin is currently listed as a starter on the depth chart, likely delegating Wilson to a depth role to begin the campaign. He's not yet on the fantasy radar, but as a 2024 day-two pick who flashed this preseason, Wilson's usage in Week 1 is worth monitoring in deeper formats.

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Kansas City Chiefs running back Elijah Mitchell is a healthy inactive for the Week 1 regular-season opener on Friday night in Brazil against the division-rival Los Angeles Chargers, according to Nate Taylor of ESPN. It's bad news for Mitchell heading into his first year with the Chiefs, as it looks like he's the RB4 to open the year, behind starter Isiah Pacheco, Kareem Hunt and rookie Brashard Smith. The 27-year-old was getting some first-team reps early in training camp, but that was a long time ago in late July. Mitchell signed a one-year, $2.5 million deal with KC in the offseason after spending his first three NFL seasons with the San Francisco 49ers. In his three years in the Bay Area, the former sixth-rounder in 2021 out of Louisiana averaged 4.7 yards per tote on 327 rush attempts for 1,523 yards and nine touchdowns (five in his rookie season).

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Las Vegas Raiders rookie wide receiver Dont'e Thornton Jr. enters Week 1 as one of the more intriguing sleepers of the 2025 draft class. The 6'5" playmaker earned a starting role ahead of Amari Cooper's retirement and will face a Patriots secondary that could be without cornerback Christian Gonzalez. Thornton's size and downfield ability have made him a favorite target for quarterback Geno Smith throughout camp, flashing legitimate big-play upside. While his early-season role carries promise, the Raiders are still expected to lean on their running game, limiting his immediate fantasy ceiling. Thornton should be stashed on benches with the potential to develop into a key contributor.

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Las Vegas Raiders wide receiver Tre Tucker enters 2025 looking to build on a solid sophomore season in which he started 14 games and produced 47 receptions for 539 yards. With Jakobi Meyers and rookie Dont'e Thornton Jr. also in the mix, Tucker opens the season as a starter but faces an uncertain target share in a run-first offense. While his speed makes him a threat on any given play, he is shaping up as a touchdown-dependent contributor rather than a reliable fantasy option. Tucker should add value on special teams as a return man, but for Week 1, he remains well off the fantasy radar.

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