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San Francisco 49ers running back Christian McCaffrey (calf) is not listed among the team's inactives for Week 1 against the Seattle Seahawks, per David Lombardi of The San Francisco Standard. McCaffrey popped up on the team's injury report earlier this week with a calf injury, but it does not appear that the injury will keep him out of the lineup for the 49ers. McCaffrey battled through multiple injuries in 2024 that caused him to miss most of the season. As long as he's active and on the field, he's a must-start fantasy running back.

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Denver Broncos running back Jaleel McLaughlin will be a healthy scratch for his team's Week 1 matchup against the Tennessee Titans, per Mike Klis of 9NEWS. Without McLaughlin, Denver's running back trio in the season opener will likely be J.K. Dobbins, RJ Harvey, and Tyler Badie. McLaughlin has played in 33 games for the Broncos over the past two seasons. Without him in the lineup, Badie may see a bit more work as the change of pace back to Dobbins and Harvey.

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Miami Dolphins cornerback Storm Duck (ankle) is questionable to return to Sunday's game against the Indianapolis Colts with an ankle injury, per ESPN's Marcel Louis-Jacques. Miami entered the game already very thin at cornerback. Louis-Jacques reports that Rasul Douglas and JuJu Brents are the only reserve cornerbacks that the team has active for Week 1, and neither player has been with the team for more than a couple of weeks.

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Pittsburgh Steelers safety DeShon Elliott (knee) is doubtful to return to Sunday's game against the New York Jets with a knee injury, per Mike DeFabo of The Athletic. Veteran Chuck Clark is next up on Pittsburgh's depth chart at strong safety. Elliott recorded 72 tackles and forced two fumbles in 15 games for the Steelers last season, so losing him would be a tough blow for the Pittsburgh defense.

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The New York Jets announced that running back Kene Nwangwu (hamstring) is questionable to return to the game against the Pittsburgh Steelers. The veteran's primary job is to be the kick returner, so the Jets placed receiver Xavier Gipson in that role in the meantime. From a fantasy perspective, Nwangwu, who has four career kick return touchdowns, is only a roster option in leagues that score return yards.

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Tampa Bay Buccaneers wide receiver Chris Godwin (ankle) is targeting a Week 5 return as he continues to recover from surgery, according to NFL Network's Ian Rapoport. Godwin opens the season on the PUP list, but he hopes to return to game action after he misses the minimum four games. With that said, Rapoport noted that Week 6 or Week 7 could also be in play for Godwin's season debut. Whenever he does return, he'll add another weapon to a phenomenal receiving corps that also includes Mike Evans and Emeka Egbuka. He'll rank as a high-end fantasy WR3 with top-15 upside.

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Green Bay Packers wide receiver Jayden Reed (foot) is expected to play in Week 1 despite being listed as questionable. The 25-year-old had been limited in each of his last two practice sessions. He's coming off a decent 2024 season in which he caught 55 passes for 857 yards and seven total touchdowns, plus an additional 163 rushing yards. He's expected to operate as the Packers' No. 2 receiver alongside Matthew Golden. His versatility allows him to rank as a modest WR3/FLEX option, and he should benefit from a potentially high-scoring game against the Detroit Lions.

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Pittsburgh Steelers outside linebacker Nick Herbig (hamstring) has been ruled inactive for the Week 1 regular-season opener on Sunday versus the New York Jets. Herbig was listed as questionable for the season opener on Friday after putting in three limited practices during the week. The 23-year-old isn't quite ready to take the field after injuring his hamstring on Aug. 16 in a preseason game, but his involvement in practices this week is a good sign that he will be able to make his 2025 debut in Week 2 versus the Seattle Seahawks. Herbig's absence is not good news for the Steelers defense, but their defense/special teams unit should still be started in Week 1 against the new-look Jets offense. With Herbig out, expect Jack Sawyer to see the field more often as a rotational linebacker for Pittsburgh.

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New York Jets wide receiver Allen Lazard is a healthy scratch for the Week 1 regular-season opener on Sunday against the Pittsburgh Steelers. With Davante Adams departing for the Los Angeles Rams in the offseason, Lazard was expected to be a starter behind Garrett Wilson in 2025, but that doesn't appear to be the case early on. The 29-year-old was a major disappointment in 2023 after signing a four-year, $44 million deal but bounced back slightly last year by catching 37 passes for 530 yards and six touchdowns in 12 games. Josh Reynolds has secured WR2 duties in New York with a strong training camp and preseason, and with Lazard being a healthy scratch in Week 1, it looks like Tyler Johnson will get first crack at WR3 duties in what is expected to be a run-heavy offense under first-year head coach Aaron Glenn.

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Per ESPN's Mike Reiss, New England Patriots rookie second-round running back TreVeyon Henderson is expected to be "very involved" in the Week 1 season opener on Sunday against the Las Vegas Raiders. "While Henderson is almost guaranteed to be on the field on third down in a pass-catching role that has been a staple in Josh McDaniels' offense, he is also expected to be given a chance on early downs as well," Reiss writes. Fifth-year back Rhamondre Stevenson is going to get the "start," but Henderson could very well lead the Pats' backfield in touches and scrimmage yards. McDaniels said Henderson's skill set is "unlike anything the Patriots have had at the position since at least the turn of the century." Henderson is a lethal threat to score anytime he touches the ball and should be in starting fantasy lineups in Week 1 for those that drafted him.

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Seattle Seahawks running back Zach Charbonnet is expected to get more work on Sunday than he has in previous seasons, according to ESPN's Adam Schefter. After plenty of speculation about the roles that Kenneth Walker III and Charbonnet would have this season, it appears that we have some additional clarity heading into the season opener. The Seahawks will likely adopt a run-heavy offensive approach this season, leaving both Walker and Charbonnet with standalone fantasy value in any given week. Not only is Charbonnet going to have a larger role than in previous years, but Bob Condotta of the Seattle Times recently reported that he could even start over Walker in Week 1. The increase in touches is well-deserved for Charbonnet, who averaged 72.2 rushing yards, 28.2 receiving yards, and one touchdown during his six games as a starter last year. As Week 1 gets underway, he is worth inserting into lineups as a strong RB3/FLEX option with RB2 upside.

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According to ESPN's Adam Schefter, Cleveland Browns rookie second-round running back Quinshon Judkins could be facing a multi-game suspension from the league after dealing with a domestic-violence case this summer. Judkins didn't sign his rookie deal until Saturday because of his off-the-field issues this summer. The Browns were granted a two-game roster exemption for the 21-year-old on Saturday, and reports earlier on Sunday suggested that it was likely that Judkins would make his NFL debut in Week 2 against the Baltimore Ravens. Fantasy managers may want to pump the brakes on Judkins' availability now, though, as he could be suspended multiple games despite the domestic-violence charges against him being dropped. For now, Jerome Ford will act as Cleveland's starter, but rookie Dylan Sampson will also be involved. Judkins needs to remain stashed in all fantasy formats.

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Houston Texans wide receiver Xavier Hutchinson is expected to get starter's snaps in the Week 1 regular-season opener on Sunday against the Los Angeles Rams, according to Ian Rapoport of NFL Network. The former sixth-rounder has impressed under the radar for the Texans going into the 2025 regular season and has an opportunity to make some noise with Christian Kirk (hamstring) ruled out for the season opener. The 25-year-old is certainly a player to watch as a fantasy sleeper early in the year, especially if Kirk misses more than one game, but it's hard to recommend him as a flex play in Week 1 in 12-team leagues with rookies Jaylin Noel and Jayden Higgins also having bigger roles behind Nico Collins with Kirk out this weekend. Hutchinson caught 12 of 26 targets for 117 yards in 16 regular-season games (three starts) for Houston in 2024 in his second year in the NFL.

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Las Vegas Raiders running back Raheem Mostert is inactive for Week 1 of the 2025 regular season on Sunday against the New England Patriots. Mostert is healthy heading into the regular-season opener, so this is a bad sign for his potential involvement in the Raiders' backfield this year in his first year with the team. The Raiders drafted rookie Ashton Jeanty in the first round in April, and he's fully expected to lead Vegas' backfield in his first year in the NFL. The oft-injured Mostert has now been bumped down the depth chart and will open the year as the RB4 behind Jeanty, Zamir White and Dylan Laube. The 33-year-old veteran can be dumped if you were rostering him as a handcuff for Jeanty in redraft leagues. Mostert led the league with 18 rushing touchdowns in 2023 in Miami but played in 13 games last year and fell to just two TDs.

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Carolina Panthers wide receiver Jimmy Horn Jr. (coach's decision) is a healthy scratch for Week 1 against the Jacksonville Jaguars. The Panthers' sixth-round pick was rumored to be an up-and-coming piece in the Carolina offense, with some speculation that he could have an immediate role in Week 1. Instead, his NFL debut will have to wait at least one more week. Dalevon Campbell is also inactive on Sunday, leaving the Panthers with five active receivers on gameday.

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New England Patriots rookie wide receiver Efton Chism III is a healthy inactive for the team's Week 1 regular-season opener on Sunday against the Las Vegas Raiders. Chism had a very strong training camp and preseason for the Patriots despite going undrafted back in April. The 23-year-old is certainly worth stashing for the long term in dynasty/keeper formats, but he belongs on the waiver wire for now in all single-year formats. With Chism being a healthy scratch in the first game of the year for the Patriots, they will roll with Stefon Diggs, DeMario Douglas, Kayshon Boutte, Mack Hollins and Kyle Williams in their wideout corps in quarterback Drake Maye's first full season as the starter under center.

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Las Vegas Raiders RB Raheem Mostert (non-injury) is a healthy scratch for Week 1's game versus the New England Patriots.

Fantasy Spin: This is a surprising development because Mostert had been viewed as the primary handcuff option for fantasy owners of RB Ashton Jeanty, who will be making his NFL debut this afternoon. Jeanty should be viewed as an RB1 option in all fantasy formats. RBs Zamir White should receive most of the remaining carries against New England, although he doesn't carry much fantasy relevance at this time.

From TheHuddle

The Tampa Bay Buccaneers have declared WR Chris Godwin, S Christian Izien, CB Benjamin Morrison, OT Tristan Wirfs, TE Devin Culp, RB Josh Williams and CB Kindle Vildor inactive for Week 1.

From TheHuddle

Ian Rapoport of NFL Network is reporting that Houston Texans running back Nick Chubb will start in Week 1 on Sunday against the Los Angeles Rams at SoFi Stadium and is expected to be the team's bell-cow back with Joe Mixon (foot) on the Non-Football Injury list to begin the season. Chubb reportedly looked really good in training camp, and the Texans are expecting big things from him this year in his first year in Houston. The 29-year-old was a four-time Pro Bowler and was one of the better RBs in the NFL before he suffered a gruesome knee injury in 2023. When he returned for the Browns last year, Chubb did not look the same and averaged a career-worst 3.3 yards per carry. However, if he's closer to his pre-injury form in 2025, he has the opportunity to be a fantastic value pick in fantasy with plenty of volume as the clear starter ahead of Dameon Pierce and rookie Woody Marks.

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New York Giants quarterback Jaxson Dart is active and will operate as the team's backup for Week 1 against the Washington Commanders. Meanwhile, Jameis Winston is inactive as the team's emergency third quarterback. This depth chart decision from the coaching staff aligns with recent rumors that indicated Dart may have earned the backup job and could even make his NFL debut in Week 1. NFL Network's Ian Rapoport recently noted that the Giants have a package of plays ready for Dart, so it's possible that he could relieve starter Russell Wilson for a handful of snaps on Sunday afternoon. Still, Dart is merely a dynasty stash at this point, as he'd need to be inserted as the full-time starter before warranting any interest in redraft leagues. Meanwhile, Winston should be left on waivers in all leagues.

From RotoBaller