San Francisco 49ers quarterback Brock Purdy (toe) is expected to return to practice on Wednesday. Purdy has missed the past two games with a turf toe injury, forcing the team to lean on backup Mac Jones. Purdy managed limited work late last week, but the 49ers ultimately held him out to give him extra recovery time. With "Mr. Irrelevant" trending toward a Week 4 return against the Jacksonville Jaguars, his presence would be a significant boost for the entire offense, especially second-year wide receiver Ricky Pearsall. While the Jaguars' defense has looked strong early in 2025, this will be the toughest offense they've faced to date. If active, Purdy should be viewed as a QB2 in Week 4.

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Indianapolis Colts tight end Tyler Warren dealt with a toe injury leading up to his team's Week 3 win over the Tennessee Titans but he ultimately played through the issue. Warren wound up catching three of his five targets for 38 yards to finish third on the team behind Michael Pittman Jr. and Alec Pierce in the blowout 41-20 win. The rookie tight end has been impressive through his first three career games, hauling in 14 of his 21 targets for 193 scoreless yards. Warren is already worth trusting as a solid TE1 in fantasy as he looks for his first career touchdown in a Week 4 road game against the Los Angeles Rams.

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Indianapolis Colts wide receiver Josh Downs was quiet in his team's 41-20 win over the Tennessee Titans in Week 3. Downs caught just two of his three targets for 34 yards to finish fourth on the team in receiving. Through three weeks with Daniel Jones under center, Downs appears to have taken a backseat to Michael Pittman Jr. as the No. 1 receiver in the Indy passing attack. The veteran slot receiver will look to bounce back in Week 4's road matchup against the Los Angeles Rams, but he's settling in as a WR5 in fantasy after a pedestrian start to the season.

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Arizona Cardinals running back James Conner (ankle) underwent season-ending surgery on Monday after suffering a significant right ankle injury in the third quarter of Sunday's game. Conner was carted off with his ankle immobilized, and head coach Jonathan Gannon confirmed he won't return this season. With Conner sidelined, the Cardinals will turn to second-year back Trey Benson, who has been highly efficient, averaging 6.0 yards per carry (second among RBs). Gannon praised Benson before the season, noting he viewed both Conner and Benson as capable starters. Benson now projects as the lead option in Arizona's backfield, while Emari Demercado is expected to mix in behind him.

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San Francisco 49ers wide receiver Demarcus Robinson has rejoined the team after serving a three-game suspension for violating the league's substance abuse policy. His return comes at a critical time, as the 49ers' receiving corps has been hit hard by injuries. Brandon Aiyuk (knee), Jauan Jennings (ankle/shoulder), and rookie Jacob Cowing (hamstring) have all missed time, while star tight end George Kittle (hamstring) remains on injured reserve. Robinson wasn't expected to carry much fantasy value entering the season, but the depleted depth chart could open up immediate opportunities, especially with quarterback Brock Purdy (toe) expected back in Week 4. In deeper formats, Robinson is worth consideration as a flex play, particularly if Jennings remains sidelined.

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Dynasty | Chargers rookie running back Omarion Hampton had 70 rushing yards, six catches, 59 receiving yards and a touchdown in a win against the Broncos. Dynasty Analysis: This performance came out of nowhere after Najee Harris went down with a season-ending injury. Hampton hadn't been great until this week but he now has a monster opportunity moving forward as he will likely slot in as a true featured back in Los Angeles. This stretch of games will likely define his career as a truly dominant stretch could preclude the Chargers from trying to find a backfield partner for him in the off-season. In short, it's go-time for Hampton, whether the Chargers wanted it or not.

Los Angeles Chargers rookie running back Omarion Hampton is set to take on a much larger role after veteran Najee Harris suffered a torn Achilles in Week 2's 23-20 win over the Denver Broncos. With Harris sidelined for the season, the Chargers will lean heavily on their first-round pick. Hampton delivered in Week 3, handling 19 carries for 70 yards and a touchdown, while also contributing six catches for 59 yards through the air. His all-around performance drew high praise from head coach Jim Harbaugh, who said after the game, "Man, what a game (Hampton) had. How about that?!" With volume on his side and a favorable schedule ahead, Hampton profiles as a high-end RB2 with the upside to finish even higher as the season progresses.

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Seattle Seahawks quarterback Sam Darnold has turned in two straight solid fantasy performances. Darnold threw for an efficient 218 yards and two touchdowns in Week 3 against the New Orleans Saints. The Seahawks did not need Darnold to do much in a game in which running back Kenneth Walker III rushed for two touchdowns and the defense dominated. However, the performance was still enough for Darnold to deliver 16.7 fantasy points in four-point passing touchdown formats. Now that Darnold looks fully comfortable in Seattle's offense, he has a chance to deliver great fantasy performances in the right matchups. The Seahawks are looking like a team that may be able to put up points in a hurry this year. Darnold already proved that he could be a solid fantasy quarterback in 2024. If you are battling quarterback injuries or poor play, keep Darnold on your radar moving forward.

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Seattle Seahawks wide receiver Cooper Kupp is looking like a player who will be difficult to trust in fantasy football this season. Kupp scored 16 fantasy points on nine targets in Week 2, but he has only earned three targets in each of the Seahawks' other two games. Kupp reeled in two receptions for 31 yards in Week 3 against the New Orleans Saints despite the Seahawks scoring 44 points. With fellow wide receiver Tory Horton earning a larger role within the offense, Kupp may be up and down this season. He is a great chain-mover and veteran for quarterback Sam Darnold to trust, but his lack of consistent targets through three weeks makes him difficult to project in fantasy. He will always be a threat to earn eight to 10 targets in any given week, but it is clear that he could have a series of dud performances throughout the year as well.

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Minnesota Vikings wide receiver Jordan Addison is set to return from his three-game suspension stemming from last summer's DUI charges. With the suspension served, Addison has returned to the team and is expected to suit up in London when the Vikings take on the Pittsburgh Steelers. Addison steps back into the WR2 role, and he'll be catching passes from backup quarterback Carson Wentz, who is coming off a strong performance in Week 3's blowout win over the Cincinnati Bengals. The Steelers' secondary bounced back last week, holding New England's wide receivers to just 93 yards on 11 catches. Given the quarterback situation and a tough defensive opponent, Addison profiles as a low-end WR3 for Week 4, though his talent keeps him on the flex radar.

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Dynasty | Chargers rookie receiver Tre Harris failed to catch his only target in a win against the Broncos. Dynasty Analysis: Harris now has just three catches for 45 yards on the season. Meanwhile the newly re-added Keenan Allen has a 19/194/3 line on the season. In short, the signing of Allen just killed any chance Harris had to make an early impact. He remains a solid dynasty stash but this is hugely disappointing to those who burned a second round rookie pick on him this off-season.

Cleveland Browns tight end David Njoku caught five of his seven targets for 40 yards in a 13-10 win over the Green Bay Packers in Week 3. Njoku wound up leading the team in receiving yards on an afternoon where they only threw for 142 yards in the upset win. The veteran tight end is off to a slow start in 2025, catching 12 passes for 117 scoreless yards through three games. The emergence of rookie Harold Fannin Jr. has been an issue for Njoku, as has a punchless passing attack led by Joe Flacco. Njoku will be on the TE2 radar heading into Week 4's road matchup against the Detroit Lions.

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Free-agent WR Cedrick Wilson (Saints) was signed to the New Orleans Saints practice squad Monday, Sept. 22.

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Dynasty | Raiders rookie running back Ashton Jeanty had 63 rushing yards and failed to record a catch in a loss to the Commanders. Dynasty Analysis: On the season, Jeanty now has 144 rushing yards and just one touchdown on 3.1 yards per carry. He's also "added" five catches for three yards through his three games. This is either a really slow start or the beginning of a total disaster. Jeanty hasn't looked like the explosive player we saw at Boise State and dynasty managers are starting to get very concerned. Managers have no other choice than to hold on to Jeanty and hope things turn around but this has not been at all the start most expected.

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Dynasty | Chargers running back Najee Harris suffered what the team expects to be a torn Achilles in a win over Denver Sunday. Dynasty Analysis: Harris went down with a non-contact injury and those are typically the worst. Signed to a modest $5 million deal this off-season, Harris will now enter next season as a free agent coming off one of the worst injuries you can have. He had some trouble generating interest this year and the injury clearly won't help. Harris was poised to start leading the Chargers backfield as Omarion Hampton had been ineffective. After a 4th of July eye injury, this turn of events simply made his quick tenure with the Chargers a disaster. He's still roster-worthy in deep leagues but it's close.

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Dynasty | Broncos running back RJ Harvey had two carries for two yards, adding three catches for 14 yards in a loss to the Chargers. Dynasty Analysis: JK Dobbins again out-touched Harvey as it was a 12-5 distribution this week. Harvey has shown some good juice but Dobbins has simply been better thus far and has seemingly earned the trust of his coaches. Harvey is still a solid stash but anyone who thought he was going to run away with this job and be a weekly option in fantasy leagues early on this season has to be very disappointed.

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Cleveland Browns wide receiver Jerry Jeudy was quiet in an upset Week 3 win over the Green Bay Packers, catching just one of his five targets for 17 yards. The entire passing offense was pedestrian in the 13-10 win as Cleveland leaned extensively on the run game to defeat Green Bay. Jeudy is posting modest numbers through three weeks as he has caught just 10 of his 21 targets for 134 scoreless yards thus far. The Cleveland pass-catchers could be in for a long season as Joe Flacco has struggle and rookie Dillon Gabriel is unlikely to provide much of a lift to the unit if he eventually takes over as QB1. Jeudy is looking like a WR4/5 in fantasy moving forward.

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Cleveland Browns tight end Harold Fannin Jr. caught three of his four targets for 25 yards in a 13-10 upset win over the Green Bay Packers in Week 3. While Fannin didn't post gaudy numbers in the surprising win, he tied for third on the team in targets and receiving yards on a day where Cleveland focused on their run game, only throwing for 142 yards. Fannin has been a pleasant surprise through three weeks, catching 15 of his 18 targets for 136 yards through three games. The rookie has impressed thus far as he has carved out a sizable role in the Browns' passing attack, making him a solid starting tight end in most fantasy leagues going forward. In Week 4 he will head on the road to take on the Detroit Lions.

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Cleveland Browns running back Dylan Sampson was an afterthought in his team's 13-10 win over the Green Bay Packers in Week 3. Sampson saw just one carry, turning it into a two-yard gain, and was not targeted in the passing attack. The rookie's role has dwindled considerably since Week 1, not surprisingly coinciding with the activation of fellow rookie Quinshon Judkins ahead of last week's game. Sampson was looking like a solid PPR flex option after a Week 1 loss to the Cincinnati Bengals, but he has quickly become a drop candidate in fantasy leagues heading into Week 4's road matchup against the Detroit Lions.

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Cleveland Browns quarterback Joe Flacco turned in another quiet performance in a 13-10 win over the Green Bay Packers in Week 3. Flacco completed 21 of his 36 passes for 142 yards and one interception in the close upset win. The veteran quarterback has now thrown for just 631 yards and two touchdowns while tossing four interceptions across three contests for the Browns this season. Flacco will presumably remain the team's starter heading into a Week 4 road matchup against the Detroit Lions, but it wouldn't be a huge surprise to see rookie Dillon Gabriel under center for the team sooner rather than later.

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