Tennessee Titans running back Tyjae Spears (ankle) could be an intriguing flex option for fantasy managers in Week 5, but only if he's activated from Injured Reserve. Spears is currently listed as questionable after logging a limited practice as the team mulls whether he's ready to rejoin the 53-man roster. He missed the first four weeks of the season while recovering from an ankle injury, but the Titans' offense looks like the worst in the NFL and could desperately use a burst of energy. Spears offers exactly that. As a rookie in 2023, we saw him command 70 targets in the passing game while maintaining 4.53 yards per carry on 100 carries. He was headed for similar numbers last year if not for missing five games due to injury. Now, he has yet another chance to carve out a role on the ground and through the air. Starter Tony Pollard has been nothing special so far, and while he'd likely continue to be the lead back for at least a little while, Spears could actually have more fantasy value due to his burst and pass-catching upside. Week 5 is a perfect opportunity for the 24-year-old to contribute as the Titans face the Arizona Cardinals, who have allowed the sixth-most targets and 12th-most fantasy points to running backs in 2025. If he suits up Sunday, Spears has the potential to be a strong flex option, especially in PPR leagues.

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Washington Commanders tight end Zach Ertz has continued to be productive in his age-34 season, catching 14 of 20 targets for 149 yards and two touchdowns. Currently the TE11 in total points scored, Ertz will benefit from having star quarterback Jayden Daniels (knee) return to the lineup, as they have built a strong rapport in their two years together. He's been less productive with veteran Marcus Mariota starting the past two games, catching five of seven targets for 59 yards. The veteran will look to get back on the right track in Week 5 against a difficult Chargers defense that has allowed the sixth fewest receptions to tight ends this season. Ertz can be trusted as a low-end TE1 for Week 5.

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Washington Commanders wide receiver Chris Moore played a big role in their Week 4 loss to the Falcons, playing the highest snap share of any Washington wide receiver. Moore ran the second-most routes on the team behind Deebo Samuel Sr. after being elevated from the practice squad ahead of Week 3. The 32-year-old wideout will likely be in line for a similar role with both outside receivers in Terry McLaurin (quadriceps) and Noah Brown (groin) ruled out. He's caught three of five receptions for 59 yards for the season. The veteran will benefit from star quarterback Jayden Daniels (knee) returning to the field, but faces a challenging matchup against the Chargers. Moore projects as a decent option in deeper leagues for Week 5 because he will likely play a good amount.

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Washington Commanders wide receiver Luke McCaffrey will have another opportunity for more playing time in Week 5. Washington continues to deal with multiple injuries at wide receiver, with Terry McLaurin (quadriceps) and Noah Brown (groin) both ruled out again for Sunday. McCaffrey has now scored touchdowns in back-to-back games without those two players, finding the end zone for the first time in his career on a 43-yard catch and run against the Raiders in Week 3. The second-year wideout, however, hasn't run a high number of routes in any game this season, despite injuries to the top of Washington's receiver room. He ran a season high of just 13 routes this past week against Atlanta. That signals that the coaching staff prefers not to use him on the outside, as journeyman receiver Chris Moore stepped into that role and ran close to a full number of routes against Atlanta. McCaffrey's role could expand this week against a stingy Chargers defense, but he's likely only playable in deeper leagues.

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Washington Commanders running back Jeremy McNichols has served as the pass-down back in their three-man running back committee. Jacory Croskey-Merritt and Chris Rodriguez Jr. have handled the bulk of the running back touches, while McNichols subs in on late downs for prowess as a pass protector. That is the driving factor behind McNichols' volume of snaps, but he's also shown some juice and physicality as a runner. He had one of the highlight runs of the season in Week 3 against the Raiders when he trucked a defender and then exploded for a 60-yard touchdown. McNichols should be expected to serve in his usual role against a tough Chargers defense, limiting his Week 5 appeal to deeper leagues.

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Carolina Panthers tight end Tommy Tremble is currently in line to make another start in Week 5 against the Miami Dolphins. The Panthers will be without Ja'Tavion Sanders (ankle) again this weekend, so Tremble will be asked to make another start. Last week, Tremble hauled in five of his eight targets for 42 yards and a touchdown in the loss. The 25-year-old saw 75 percent of the offensive snaps. This was a nice performance from Tremble, but it's unclear if he can do it again. It's worth noting that wide receiver Xavier Legette (hamstring) is back in the mix after a two-game absence. It's tough to imagine Tremble getting eight targets again, but there should still be TE2 value here.

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Washington Commanders wide receiver Deebo Samuel Sr. has had an outstanding start to the season and his time in Washington. He's shouldered a big load for the Commanders' passing attack as they deal with multiple injuries. He leads the team in targets, receptions, yards, and touchdowns. Not to mention, he's been the best kick returner in football, averaging a league-best 36.8 yards per return. Samuel will be leaned on heavily again in Week 5 as Washington will be without wide receivers Terry McLaurin (quadriceps) for the second straight game and Noah Brown (groin) for the third straight. The Washington offense also gets a big boost with star quarterback Jayden Daniels (knee) returning to the field in Week 5. It's a tougher matchup against a Chargers defense that has allowed the fourth fewest fantasy points per game to opposing wide receivers, but Samuel still ranks as a borderline WR1 for Sunday.

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Carolina Panthers running back Trevor Etienne is expected to see additional carries in the backfield in Week 5. The Panthers are going to be without Chuba Hubbard (calf) for this weekend. That being said, Rico Dowdle will be the lead back with Etienne as the primary backup. The 21-year-old hasn't done much early in the season. Last week, Etienne rushed the ball seven times for 33 yards in the loss to the New England Patriots. It was a limited workload, but the 4.71 yards per carry is nice to see. His workload will likely also be dependent on the game flow as the Panthers could abandon the running game if it becomes a blowout. The hope is that Etienne gets about 10 touches, which might be able to give him deep league value for this game against the Miami Dolphins.

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Washington Commanders running back Chris Rodriguez Jr. has led the backfield in carries and rushing yards over the last two weeks, compiling 98 yards on 18 attempts. Rodriguez has served as an early down hammer back this season, with him being brought up to the active roster after Austin Ekeler was lost for the season in Week 2. Rodriguez has tied for the lead in snaps with rookie Jacory Croskey-Merritt in the past two weeks and should continue to be involved on early downs and in short distances. He faces a tough test against a Chargers defense that has given up the fewest amount of fantasy points to running backs this season. Rodriguez is best left out of lineups for Week 5.

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Carolina Panthers wide receiver Hunter Renfrow has been off to a slow start to begin the season. Renfrow had a breakout performance in Week 2 with seven receptions for 48 yards and two touchdowns. Outside of that, Renfrow has been held to two receptions and 11 yards or less in every game. The return of Xavier Legette this week isn't going to do him any favors. Sooner rather than later, the Panthers are going to lean on their younger players and push Renfrow further out of the rotation. Last week, Renfrow played less than 50 percent of the offensive snaps. He's worth holding in deep leagues, but Renfrow shouldn't be trusted in Week 5.

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Tennessee Titans tight end Chig Okonkwo posted a dud during last week's loss to the Houston Texans. He hauled in one of his three targets for four yards in the blowout defeat. This was a frustrating performance after Okonkwo hauled in five receptions for 66 yards in Week 3. The 26-year-old is still building chemistry with quarterback Cam Ward early in the season. This whole offensive unit has been struggling early in the season. The hope is that Okonkwo bounces back during the upcoming Week 5 matchup against the Arizona Cardinals. He shouldn't be viewed as anything more than a TE2.

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Tennessee Titans wide receiver Elic Ayomanor has been one of the few bright spots for this offense through four games. It has been a tough beginning to the season for the Titans offense. However, Ayomanor has been decent with 12 receptions for 151 yards and two touchdowns through four games. The rookie wideout saw seven targets last week, but only hauled in two of them for 44 yards. The Titans offense is a complete mess, but Ayomanor has good upside. He should be in the conversation as a flex option for the upcoming Week 5 matchup against the Arizona Cardinals.

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Tennessee Titans wide receiver Calvin Ridley (knee, elbow) is currently considered questionable for the upcoming Week 5 matchup against the Arizona Cardinals. Ridley didn't practice for back-to-back days before getting in a limited practice session on Friday. When healthy, Ridley hasn't been much of a fantasy option anyway. Ridley has three receptions for 57 yards over the last two games. The Titans offense is a mess right now, so it's tough to trust anyone on this offense. If healthy, Ridley should be considered a low-end flex option for Week 5.

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Washington Commanders running back Jacory Croskey-Merritt has weekly upside because he's been so efficient and dynamic on his touches, but the role is still murky as part of a three-man committee in the Washington backfield. Croskey-Merritt is tied with third-year back Chris Rodriguez Jr. in snap share over the past two weeks without Austin Ekeler, each playing 37.4% of the snaps and earning 18 touches apiece. Veteran back Jeremy McNichols has filled in primarily on late downs, playing 11 of 19 third and fourth-down plays over the past two weeks. Croskey-Merritt's role should continue to increase as he gets more experience. The rookie has been one of the most efficient runners in the league over his first month of NFL games. His 5.8 yards per carry ranks second best, while his 58.6% success rate is the best among all running backs. That may not continue in a tough Week 5 matchup against the Chargers, as they have been the stingiest defense against the run. They've allowed just 10.6 PPR points per game on the season. That leaves Croskey-Merritt as a low-end flex play in Week 5.

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Washington Commanders quarterback Jayden Daniels (knee) practiced in full every day this week and will return as the starter in Week 5 against the Chargers. Daniels banged up his knee in Washington's Week 2 loss at Green Bay and missed the following two weeks, where veteran Marcus Mariota filled in admirably. Daniels will be without his top two outside receivers as Terry McLaurin (quadriceps) and Noah Brown (groin) are both ruled out again for Sunday's game. And Daniels will reportedly be wearing a brace on his injured knee, perhaps limiting how often he runs. The star second-year quarterback faces a tough matchup in his return to play, facing a Los Angeles Chargers defense that has allowed the fourth-fewest total points scored and third-fewest yards allowed. Daniels still ranks as a solid QB1 for Week 5.

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Jacksonville Jaguars wide receiver Dyami Brown (shoulder) was limited in practice on Friday for the second straight day this week. Brown was held out of the Week 4 win over the Jacksonville Jaguars with his shoulder injury, and his status for the Monday night showdown in Week 5 against the Kansas City Chiefs is up in the air. The 25-year-old pass-catcher will likely need a full practice on Saturday to avoid a questionable tag going into Monday night. Even if Brown ends up being active on Monday night, he'll be a much too risky flex play in deeper fantasy leagues against a stingy and experienced Chiefs defense. Brown was surprisingly involved in the first two weeks, catching eight of 11 targets for 109 yards and a touchdown, but fantasy managers can't realistically expect that kind of production to continue while he shares targets with Brian Thomas Jr., rookie Travis Hunter, and Parker Washington.

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Jacksonville Jaguars rookie running back Bhayshul Tuten (shoulder) was limited in practice for the second straight day this week on Friday with a shoulder ailment. Tuten hasn't missed any time yet in his rookie campaign, but if he doesn't put in a full practice on Saturday, he could be questionable to play on Monday night in Week 5 against the Kansas City Chiefs. The 23-year-old feels safe to be active on Monday night, but his final injury status is worth watching on Saturday. Travis Etienne Jr. is the Jags' No. 1 back, but Tuten has been involved and has already shown his big-play ability early on. Tuten has averaged seven touches a game and 39 scrimmage yards while finding the end zone two times in the last three games. Against a stout Chiefs run defense, though, Tuten will merely be a touchdown-dependent RB3/flex for fantasy managers if he's active.

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Las Vegas Raiders All-Pro defensive end Maxx Crosby (knee) was removed from the final Week 5 injury report on Friday and will play on Sunday against the Indianapolis Colts on the road. Crosby was added to the injury report after being limited on Thursday with a knee injury. However, he was able to practice in full on Friday and is in no danger of missing this weekend's contest. The 28-year-old pass-rusher needs to be in all starting lineups in IDP formats against the Colts as he looks for his third sack of the year against quarterback Daniel Jones. The 28-year-old four-time Pro Bowler is an elite pass-rusher in the NFL and has 19 tackles (11 solo), two sacks, seven tackles for loss, five QB hits, an interception, and a forced fumble in the first four games in 2025.

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Baltimore Ravens linebacker Roquan Smith (hamstring) has been ruled out for the Week 5 game against the Houston Texans, while star cornerback Kyle Hamilton (groin) is considered questionable. The Ravens' defense is one of the most beat-up in the league early in the year. In addition to Smith being ruled out, cornerbacks Chidobe Awuzie (hamstring) and Marlon Humphrey (calf) have also been ruled out. It will make life a lot easier on a struggling Texans offense looking for its second straight win this weekend. Smith is perhaps Baltimore's biggest defensive piece, but he's expected to miss multiple weeks after suffering a Grade 2 hamstring strain in last week's loss to the Kansas City Chiefs. It's hard to trust the Ravens' defense/special teams unit in fantasy after their rough start, especially with more injuries knocking key players out. However, the friendly matchup against Houston puts them in streamer territory.

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Seattle Seahawks wide receiver Jaxon Smith-Njigba should have no problem getting free against the Tampa Bay Buccaneers on Sunday. The Buccaneers are currently sixth against opposing wideouts in fantasy, but they have not exactly faced a potent passing offense to this point. The Seahawks have been relatively efficient passing the ball thus far this season. A great connection between JSN and quarterback Sam Darnold has anchored that efficiency. Smith-Njigba is currently the WR7 in fantasy with only one touchdown. He has been a target monster in an offense that has been able to move the ball up and down the field. The Buccaneers have an equally competent offense, which suggests that this game could be somewhat of a high-scoring game. If the Seahawks are airing it out consistently on Sunday, Smith-Njigba should produce as a WR1 again.

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