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Tampa Bay Buccaneers quarterback Baker Mayfield (bicep) and left tackle Tristan Wirfs (knee) are expected to play in Sunday's Week 4 contest against the Philadelphia Eagles, according to ESPN's Adam Schefter. Both players are listed as questionable. Mayfield has looked great through three games, totaling six touchdowns and zero interceptions while ranking as the overall QB10. His protection has taken a step back this year due to offensive line injuries, but he'll get a major reinforcement this week with Wirfs back in the mix. Wirfs missed the first three games of the season but could return to play every offensive snap in Week 4. His presence is key as the Buccaneers work to protect Mayfield's blindside.

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Tampa Bay Buccaneers wide receiver Chris Godwin (ankle) is expected to play in Sunday's Week 4 contest against the Philadelphia Eagles, according to ESPN's Adam Schefter. With that said, it's worth noting that NFL Network's Ian Rapoport indicated that Godwin could be on a snap count for his 2025 season debut. Even if he doesn't play a full array of snaps, Godwin is still an intriguing fantasy option. He excelled before getting hurt last year and should pick up right where he left off as he fills the void of Mike Evans (hamstring). He should be viewed as a mid-to-low WR2 this weekend, with the potential to climb up rankings even further going forward.

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Cleveland Browns head coach Kevin Stefanski offered a shoutout to quarterback Shedeur Sanders heading into Week 4 against the Detroit Lions. "[Sanders] has done a good job," Stefanski said. "I think all our guys feel like they're ready and they're working hard." These comments paint a slight picture of Sanders' potential role going forward, but they also fail to differentiate him from fellow rookie Dillon Gabriel or even current veteran starter Joe Flacco. Flacco earned himself some of the coaches' trust last week as he led the Browns to a victory over the Packers, who had been 2-0. As for Sanders, he'll continue to watch from the sideline and can be dropped in all redraft leagues.

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Washington Commanders quarterback Jayden Daniels (knee) was pushing to play against the Atlanta Falcons before ultimately being ruled out, according to ESPN's Jeremy Fowler. Instead, Daniels is now targeting a Week 5 return. Fowler noted that the former No. 2 pick could have possibly played this week if he were an older, less-mobile quarterback, but the fact that he likes to run with the football makes it tougher for him to play through a knee issue. Marcus Mariota will start at quarterback once again this week.

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Washington Commanders wide receiver Terry McLaurin (quad) will not be placed on injured reserve as he works to recover from an injury suffered in Week 3 against the Las Vegas Raiders, according to Jeremy Fowler of ESPN. However, there is still some uncertainty surrounding his status, as he is being evaluated on a week-to-week basis and does not have a specific timetable for his return. The 31-year-old could be headed for a multi-game absence, putting Deebo Samuel Sr. in line to rank as a low-end WR2 while Zach Ertz, Jaylin Lane, and Luke McCaffrey also see opportunity spikes, too.

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Pittsburgh Steelers head coach Mike Tomlin said that he is "pleased" with running back Kaleb Johnson's progress, and he believes the rookie has "positioned himself to be a contributor" this week against the Minnesota Vikings. He acknowledged that Johnson has had to earn his way back into the offense after a costly special teams miscue back in Week 2. The 22-year-old had just two carries through his first two games before being a healthy scratch last weekend. It sounds like he'll play this Sunday, but his exact role remains up in the air. He should continue to be stashed on the bench in redraft leagues with at least 14 teams, as well as all dynasty formats.

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Indianapolis Colts kicker Spencer Shrader has been busy to start the year, hitting 11 of his 12 field-goal attempts and all 10 of his extra-point tries. The veteran kicker will look to keep it going in a Week 4 road matchup against the Los Angeles Rams. The Rams have been generous to fantasy kickers thus far, allowing the sixth-most fantasy points per game to the position thus far. The Colts have employed one of the best offenses in the league through three games and Shrader should continue to see plenty of point-scoring chances heading into Week 4. Treat him as a top-12 fantasy kicker this weekend.

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New York Giants kicker Graham Gano (groin) has been ruled out for Week 4 against the Los Angeles Chargers, according to ESPN's Adam Schefter. Younghoe Koo will kick in his absence. Gano initially suffered the injury during warmups before last week's game against the Chiefs. He did convert a field goal in that game, but was still used sparingly. Now, there's a chance that he could be placed on IR as he recovers. Meanwhile, Koo was cut loose by the Falcons after missing a potential game-winning field goal in Week 1. He's capable of kicking far with accuracy, but his volume remains uncertain as the Giants could face some growing pains in quarterback Jaxson Dart's first career start.

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Indianapolis Colts wide receiver Josh Downs is off to a quiet start to the season, catching 10 passes for 97 scoreless yards through three games. As emerging as the Colts' top option in 2024, the slot receiver has taken a backseat to Michael Pittman Jr. and Tyler Warren in the team's passing attack with quarterback Daniel Jones under center. That being said, he could see more work come his way with Alec Pierce (concussion) already ruled out for Week 4. Downs will look to get on track in a road matchup against the Los Angeles Rams on Sunday. The Rams are allowing the 14th-most fantasy points per game to receivers this season. Downs sets up as a middling flex option in fantasy this weekend with the hope that he sees more targets with Pierce unavailable.

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Indianapolis Colts wide receiver Adonai Mitchell has been quiet through the first three games of the season, catching just four passes for 41 scoreless yards thus far. He has a chance to earn more work in Week 4, however, as Alec Pierce (concussion) has already been ruled out after suffering a concussion in Week 3. Mitchell will slide into the starting lineup across from Michael Pittman Jr. heading into a Week 4 road matchup against the Los Angeles Rams. While it is a risky move for managers, Mitchell is on the board as a boom/bust flex option in fantasy heading into Sunday's games.

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Indianapolis Colts tight end Tyler Warren will look to continue a hot start to his rookie season in a Week 4 road matchup against the Los Angeles Rams. Warren has caught 14 passes for 193 yards through three games as he and Michael Pittman Jr. have been the focal points for Daniel Jones in the passing attack. The Rams represent a decent matchup for Warren as they are allowing the 18th-most fantasy points per game to tight ends this year. Warren sets up as a top-eight fantasy tight end heading into Week 4.

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Indianapolis Colts running back DJ Giddens has become an afterthought in his team's offense. The rookie saw 12 carries in Week 1 but has handled just one touch in the two games since, as Indy has leaned heavily on starter Jonathan Taylor. The return to health of Tyler Goodson has also cut into Giddens' workload as the former is now over a preseason elbow injury. It appears that Goodson is still behind Giddens for now, as he saw four snaps to Giddens' eight in Week 3, but his return to health muddies the backup running-back role in Indianapolis. For now, Giddens remains the better stash in case of injury to Taylor, but neither he nor Goodson is a must-roster heading into a Week 4 matchup against the Los Angeles Rams.

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Indianapolis Colts wide receiver Michael Pittman Jr. has emerged as the favorite target of new quarterback Daniel Jones through the first three weeks of the season. Pittman has been excellent thus far, catching 16 passes for 193 yards and two touchdowns, easily pacing the Colts in all three categories. The veteran wideout will look to keep it going in a Week 4 road matchup against the Los Angeles Rams. The Rams have been decent against wideouts this season, allowing the 14th-most fantasy points per game to the position. Pittman should remain the focal point of the Indy offense as they look to improve to 4-0 on the year. He sets up as a high-end WR3/flex option in Week 4.

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Indianapolis Colts running back Jonathan Taylor has been one of the top fantasy players through the first three weeks of the season, rushing for 338 yards and three touchdowns while adding 93 receiving yards and another score through the air. Taylor will look to stay hot in Week 4 in a road matchup against the Los Angeles Rams. The Rams represent a tough matchup for Taylor as they are allowing the fewest fantasy points per game to the running back position through three weeks. That being said, Taylor remains one of the few true workhorses left in the league and can still be trusted as a top-six fantasy running back this weekend despite the difficult matchup.

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Indianapolis Colts quarterback Daniel Jones' performance has been a pleasant surprise over the first month of the season. Jones has led one of the top offenses in the league thus far, throwing for 816 yards, three touchdowns, and no interceptions while adding three rushing touchdowns. The Colts will look to stay hot in a road matchup against the Los Angeles Rams. The Rams are allowing the 17th-most fantasy points per game to opposing quarterbacks, giving Jones a decent matchup to stay hot. He checks in as a low-end QB1 in fantasy heading into Sunday.

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San Francisco 49ers tight end Jake Tonges has emerged as the team's top receiving option at the position during George Kittle's (hamstring) absence. Even though Luke Farrell is listed at the top of the team's depth chart, Tonges has more targets (11, to Farrell's four) and is seeing considerably more time on the field. Still, Tonges is well behind Christian McCaffrey and the 49ers' wide receiver corps in the pecking order of pass distribution. However, there is a chance for Tonges to get more attention in Week 4, since Ricky Pearsall (knee) and Jauan Jennings (ankle/shoulder) are both questionable. Also benefiting Tonges is the return of quarterback Brock Purdy (toe/shoulder) following a two-week absence. Even with those factors in play, Tonges is projected just outside of TE2 territory and should be left on the waiver wire for Week 4.

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San Francisco 49ers wide receiver Kendrick Bourne drew a start in Week 3, thanks to Jauan Jennings (ankle/shoulder) being scratched just hours before gametime. With Demarcus Robinson returning from suspension this week, the expectation was that Bourne would be crowded out of the wide receiver rotation. However, the door may be open for a second start as both Jennings and Ricky Pearsall (knee) are listed as questionable for Week 4. Last week, Bourne turned six targets into four catches for 38 yards. With Brock Purdy (toe/shoulder) deemed Sunday's starter, Bourne would see better quarterbacking than he had with Mac Jones (knee) under center, improving his odds for a more productive day. Everything rides on the health of his teammates, though, so interested fantasy managers need to monitor the situation through the weekend.

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San Francisco 49ers wide receiver Jordan Watkins (calf) has been ruled out for the team's Week 4 game against the Jacksonville Jaguars. Watkins is listed with a calf injury, a possible symptom of the high ankle sprain he suffered in the first week of preseason action. He was cleared to make his regular season debut in Week 2, but was ultimately declared inactive ahead of the game. In Week 3, he had one limited practice sandwiched between two DNPs and did not practice at all this week. Even after he heals, he has little to no value in fantasy football (dynasty leagues excepted), as it will be hard for the rookie to crack the rotation of Ricky Pearsall (knee), Jauan Jennings (ankle/shoulder), and Demarcus Robinson at the top of the depth chart.

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San Francisco 49ers running back Jordan James did not appear on the team's injury report for the first time this season. James suffered a broken finger in early August, before preseason games started, and it lingered into the regular season. James had one full practice in Week 2 and three consecutive full sessions in Week 3, but was a healthy scratch from both games, so he is still waiting to make his professional debut. With Christian McCaffrey at the top of the depth chart and Brian Robinson Jr. having a firm grasp as his direct backup, James is unlikely to see much, if any, time on the field if he suits up on Sunday. As such, he has no value in fantasy football going into San Francisco's Week 4 game against Jacksonville.

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San Francisco 49ers running back Isaac Guerendo has yet to see an offensive snap in 2025, and there is little reason to expect that to change in Week 4. Christian McCaffrey is the team's unquestioned starter, and Brian Robinson Jr. has the second position on the depth chart locked down. The team's official depth chart lists both Guerendo and rookie Jordan James as the third-string running back, raising the question of which of the two would be given an opportunity in the backfield should the need arise. In the meantime, Guerendo has been relegated to kick return duty. Through three games, he has taken back four kicks for a grand total of 82 yards. Until an injury shakes up the depth chart, Guerendo has no place on fantasy football rosters.

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