Baltimore Ravens quarterback Lamar Jackson returned from a three-game absence and picked apart the Miami Dolphins for four touchdowns through the air with a 78.3 completion percentage. He'll have a tougher task ahead of him in Week 10 against the Minnesota Vikings. They're around the middle of the pack in terms of fantasy points allowed to opposing QBs, with an average of 16.62 per game. Over the last three weeks, however, the Vikings have given up 19 or more fantasy points in each game. Jackson is already a must-start, and should continue to roll while the offense is the healthiest it's been all season.

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Indianapolis Colts wide receiver Alec Pierce is coming off his best game of the season, catching six of 13 targets for 115 yards in a 27-20 loss to the Pittsburgh Steelers. Pierce has been a big-play machine in 2025, averaging 20.9 yards per catch, although he surprisingly is still looking for his first touchdown of the season. He will look to find the end zone in a Week 10 matchup against the Atlanta Falcons in Berlin, Germany. The Falcons have done a good job limiting opposing receivers this season, allowing just the 26th-most fantasy points per game to the position thus far. That being said, the Colts have been explosive on offense and should be able to move the ball on Sunday. Fantasy gamers can treat Pierce as a boom/bust flex option in Week 10.

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Indianapolis Colts wide receiver Josh Downs has been on a hot streak of late, scoring a touchdown in three straight games. Overall the veteran slot receiver has hauled in 35 passes for 313 yards and three scores in eight games in the explosive Indy offense while taking a backseat to Michael Pittman Jr. and Tyler Warren this season. Downs will look to find the end zone again in a Week 10 matchup against the Atlanta Falcons in Berlin. The Falcons have been tough on opposing receivers this season, allowing the 26th-most fantasy points per game to the position. Downs will have his work cut out for him, but he can be trusted as a solid WR4/flex option for fantasy gamers heading into Week 10.

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Dallas Cowboys wide receiver Ryan Flournoy took advantage of his opportunities earlier in the season with CeeDee Lamb missing three weeks due to an ankle injury. Flournoy had a career day in Week 5 against the Jets, catching six of his nine targets for 114 yards. The 26-year-old has since slid back into a rotational role with Lamb back healthy, but he's still finding ways to make an impact. Flournoy caught his first career touchdown in Dallas' Week 9 loss to the Arizona Cardinals while playing 67.2% of the snaps, his most since Week 6, before Lamb returned to the lineup. Flournoy has the size and athleticism to be a part of the Cowboys ' wide receiver sets alongside Lamb and George Pickens, and could still have some deep league fantasy value in the Cowboys' high-volume passing attack. Dallas will be on primetime again on Monday Night Football at the Las Vegas Raiders in Week 11 when they return from their bye.

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Indianapolis Colts quarterback Daniel Jones has been one of the most exciting comeback players of the year, throwing for 2,404 yards, 14 touchdowns, and six interceptions while rushing for five scores on the ground. That being said, he turned in his worst game of the season in a Week 9 loss to the Pittsburgh Steelers, throwing one touchdown and three picks. Jones will look to bounce back against the Atlanta Falcons in Berlin, Germany in Week 10. The Falcons have been a tough challenge for quarterbacks in 2025, allowing just the 27th-most fantasy points per game to the position. That being said, Jones has been a reliable fantasy option almost every week and can be trusted as a low-end QB1 in Week 10.

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Indianapolis Colts running back Jonathan Taylor has been one of the most dominant fantasy players in the league this season, racking up 14 all-purpose touchdowns in nine games. The Pittsburgh Steelers in Week 9 were one of the few teams able to slow the elite rusher down, holding him to 45 scoreless rushing yards on 14 carries. Taylor will look to get back into the end zone in a Week 10 matchup against the Atlanta Falcons in Berlin. The Falcons have shut down passing attacks but have been beatable on the ground this season, allowing the 10th-most fantasy points per game to opposing running backs. That sets up Taylor for a big day as the Colts are likely to lean on the run game against Atlanta. He settles in as a top-three fantasy RB in Week 10.

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Houston Texans wide receiver Jaylin Noel had a few good weeks while filling in for Christian Kirk, but with Kirk back from his hamstring injury last week, Noel didn't have a catch and lost three yards on his only carry to finish with negative fantasy points. The rookie from Iowa State still has upside, but he's not likely to be involved enough in this week's contest to be relevant for fantasy. With Davis Mills replacing C.J. Stroud (concussion), the offense will likely be more conservative, and Kirk and Nico Collins will do most of the heavy lifting at receiver since they're back from injury. This week, Noel is only the No. 81 WR in RotoBaller's rankings, leaving him well outside of a starter spot in almost all formats.

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Houston Texans tight end Dalton Schultz has been a solid PPR producer this season, and his high volume of targets on short passes gives him a high floor again this week against the Jaguars. The Jaguars have given up the second-most fantasy points per game to tight ends this season, and Schultz has turned his 6.0 targets into 4.8 catches per game, although only for 48.1 yards per game and no touchdowns. Schultz has at least five catches in five of his last six games after hauling in six catches for 77 yards last week against Denver. He hasn't hit 100 yards or found the end zone, but his consistent involvement makes him a bye-week or injury fill-in option or a strong second tight end. He's the No. 19 TE this week in RotoBaller's rankings and is a little higher-risk with Davis Mills replacing C.J. Stroud, but Schultz has been consistently involved enough to still bring upside in this favorable matchup.

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Houston Texans wide receiver Christian Kirk is a high-risk play in all formats in Week 10 when his team hosts the Jaguars. Kirk just returned from a two-game absence due to a hamstring injury, but he'll now be without his starting quarterback, C.J. Stroud (concussion), for at least this week. He had four catches for 26 yards on eight targets last week against Denver and has at least three catches in each game this season, but only for 135 scoreless yards. Backup QB Davis Mills will likely manage the game while the team relies on its excellent defense. Kirk typically gets enough receptions to deserve a little PPR attention, but with a new QB and likely a conservative game plan, he is very high-risk this week. RotoBaller has him ranked as the No. 53 WR this week, so he should be left on the bench or waiver wire in most formats.

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Houston Texans wide receiver Jayden Higgins has flashed some potential in his rookie season and has 14 catches for 159 yards and two touchdowns in his eight games this year. He stepped up a little when Nico Collins and Christian Kirk were both injured, but he returned to a limited role with just one catch for four yards in last week's loss to the Broncos. With both veteran receivers healthy and Davis Mills filling in for the injured C.J. Stroud (concussion), Higgins is not likely to be heavily involved this week. He does have big-play or touchdown-dependent upside, but he is only WR76 in RotoBaller's rankings, so he can be left on the bench in almost all formats.

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San Francisco 49ers quarterback Mac Jones (knee) is expected to draw his eighth start of the season in Week 10 against the Los Angeles Rams. Brock Purdy (toe) is listed as questionable after a week of limited practices, and would serve as Jones' backup if active. The last time Jones faced the Rams, he enjoyed his best game of the season, passing for 342 yards and two touchdowns with no turnovers, and did so with Ricky Pearsall (knee), Jauan Jennings (ankle, shoulder), and George Kittle out due to injury. It was an exceptional lapse for the Rams' defense, which has given up just nine passing touchdowns and has allowed only one other top-12 finish to an opposing quarterback this season. This time around, Jones will still be missing Pearsall but has Jennings and Kittle back in his arsenal. Jones projects as a mid-range QB2, making him viable in two-QB formats.

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San Francisco 49ers running back Christian McCaffrey took a while to get things going on the ground, but now has reached 100 rushing yards in two of his last three games. However, in the game between, McCaffrey put up his worst numbers of the year in a slog against the Houston Texans. On Sunday, McCaffrey again faces another tough opponent in the Los Angeles Rams. The Rams have allowed the fewest fantasy points per game to opposing running backs, the sixth-fewest rushing yards, and have yet to give up a touchdown on the ground to the position. When the teams met in Week 5, McCaffrey had just 2.6 yards per carry but logged an 8-82-1 line as a receiver. Despite the difficult matchup, McCaffrey's talent makes him a weekly contender to finish as a top-12 back, and he should be locked into fantasy lineups this weekend.

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San Francisco 49ers running back Brian Robinson Jr. had a season-high 53 rushing yards and his first touchdown of the season in Week 9 against the Giants. The production gave him his first RB2 finish of 2025. Robinson is unlikely to repeat last week's success when the 49ers host the Rams on Sunday. For one, the opportunity for Robinson to produce consistently is not there. Operating as an infrequently used change-of-pace back behind Christian McCaffrey has resulted in an average of 10 offensive snaps and 4.6 rushing attempts per game. Secondly, when Robinson does get on the field in Week 10, he will be up against a Rams defense that held him to 12 yards on five carries and offered McCaffrey 2.6 yards per carry in Week 5. Robinson projects as an RB5 and is better left on the bench in Week 10.

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San Francisco 49ers wide receiver Jauan Jennings (ankle, shoulder) carries no designation into the team's Week 10 rematch with the Los Angeles Rams. Jennings, along with Ricky Pearsall (knee) and George Kittle, missed the teams' first matchup in Week 5 due to injuries, leading to a ten-catch, 142-yard bonanza for Kendrick Bourne. Jennings himself torched Los Angeles to the tune of 11-175-3 in Week 3 last season. Since returning from his absence, Jennings has not been very productive, though he still has been a focal point of the 49ers' offense. Over the last three weeks, he had a 24.7% target share and 34.6% air yard share. The Rams will likely have their attention focused on Christian McCaffrey on Sunday, which could open things up for Jennings to take another step forward. He projects as a WR3 and can be started in most leagues in Week 10.

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San Francisco 49ers wide receiver Kendrick Bourne is in line for another start on Sunday when the team hosts the Los Angeles Rams. The last time the divisional rivals squared off, in Week 5, Bourne exploded for 142 yards on 10 catches. Bourne was pushed to the top of the pecking order in the Niners' passing attack in that game due to the injury-related absences of Ricky Pearsall (knee), Jauan Jennings (ankle, shoulder), and George Kittle. Pearsall will miss a fifth consecutive game in Week 10, but Bourne will share the field with a healthy Jennings and Kittle this time. Since both returned to action in Week 7, Bourne has registered a total of seven catches for 92 yards on eight targets. Bourne projects as a lower-end WR4 in Week 10, making him a flex candidate in deeper leagues but not a must-start by any stretch.

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San Francisco 49ers wide receiver Demarcus Robinson will be granted at least one more week as the team's third wide receiver while Ricky Pearsall (knee) sits out a fifth consecutive game. Working behind Christian McCaffrey, Jauan Jennings (ankle, shoulder), George Kittle, and Kendrick Bourne in the pass game will leave few opportunities for Robinson. In Week 5, when the 49ers and Rams met for the first time in 2025, Robinson was held to three catches for 39 yards, even though Jennings, Pearsall, and Kittle were all absent due to injury. Since Jennings and Kittle rejoined the starting lineup in Week 7, Robinson has seen a total of five targets and was held without a catch in two of San Francisco's three games. In Week 10, Robinson should not be on fantasy football rosters, let alone starting lineups.

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Seattle Seahawks wide receiver Jaxon Smith-Njigba should continue to dominate fantasy football in Week 10 against the Arizona Cardinals. Although the Cardinals are No. 11 against opposing wide receivers in fantasy, Smith-Njigba has proven himself to be matchup-proof this season. The Cardinals are the only team to hold Smith Njigba to less than 96 yards or 18.3 fantasy points this season. However, that game was played in Week 4. A lot has changed since then, and Smith-Njigba has evolved into perhaps the best wide receiver in the league at the moment. Since Week 4, Smith-Njigba has not recorded fewer than 123 receiving yards or 22 fantasy points. He is about as automatic as they come. With the Seahawks' offense reaching such a high level over the last few weeks, Smith-Njigba has a great chance to continue his stats in both categories. Nobody is going to bench Smith-Njigba while he is playing like this, but you can expect another monster game in Week 10 from the third-year man.

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Seattle Seahawks kicker Jason Myers should have plenty of chances to rack up points on Sunday against the Arizona Cardinals. Myers has always been an accurate kicker, but Seattle's ascension as an office is providing Myers with a lot of shots at field goals and extra points. Myers enters Week 10 averaging 9.75 fantasy points as a kicker. He is providing your team with legitimate low-end flex value in your kicker spot. Best of all, Myers is doing so consistently. He has reached double-digit fantasy points three times this season. The Cardinals boast a solid defense, but they will be traveling to Seattle in Week 10. The home-field advantage should help Seattle be successful offensively. Trust Myers as a high-end kicker option in Week 10 and beyond.

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Seattle Seahawks running back Zach Charbonnet has been wildly inefficient and ineffective this season. However, he remains fantasy relevant because his role at the goal line is netting touchdowns. Charbonnet will face a solid Cardinals defensive front in Week 10 as he continues to split time with fellow running back Kenneth Walker III. Either way, Charbonnet's inefficiencies make him difficult to trust as a legitimate starter for fantasy this week. Fortunately, Seattle's offense should have no issue moving the ball up and down the field against the Cardinals. Charbonnet already scored on this team in Week 4, and he should have had a second score in that game. With another four teams on bye in Week 10, you could throw Charbonnet in your flex and hope for a touchdown. He is a better bet than what you are likely able to scrape together on the waiver wire this week.

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Seattle Seahawks quarterback Sam Darnold should be a quality option at the position in Week 10 against the Arizona Cardinals. Darnold has been on a tear recently. He is coming off an impressive four-touchdown performance against the Commanders in Week 9. Darnold is comfortable in the offense, and it shows. The matchup with the Cardinals is not scary. While Arizona does boast a solid defense, Darnold already took advantage of this matchup in Week 4. The Cardinals have not seen an offense as dialed in as Seattle's yet this season. As such, Darnold has a great chance to exceed the 16.08 fantasy points he scored in Week 4. As long as wide receiver Jaxson Smith-Njigba continues to play at a high level, Darnold will succeed for fantasy. Start him as a quality QB1 in Week 10.

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