Tampa Bay Buccaneers running back Bucky Irving (foot, shoulder) was seen "making some grabs" during Wednesday's practice. Irving has not played since suffering foot and shoulder injuries back in Week 4, but he was limited in practice all of last week and is nearing a return to Tampa's backfield. The 23-year-old is probably going to need to do more in practice this week to have a shot at playing in Week 12 versus the Los Angeles Rams on Sunday Night Football. Fantasy managers will want to keep a close eye on his status the rest of the week, but a difficult decision is likely coming this weekend, especially with the Bucs playing on Sunday night. If Irving is cleared to make his return in Week 12, fantasy managers could be looking at a three-man, hot-hand approach in the team's backfield with Irving, Rachaad White and Sean Tucker, who exploded for three touchdowns last week.

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Per the Pewter Report, Tampa Bay Buccaneers wide receiver Chris Godwin (leg) was not seen at the portion of practice on Wednesday that was open to the media. Godwin has not played since injuring his fibula in Week 5, but he's been making progress and was limited in practice all of last week. A DNP to begin this week would be a downgrade for the 29-year-old, but we'll have to wait and see what his official status is. The Bucs have been bringing Godwin along slowly after he suffered a dislocated ankle in Week 7 of last year, which was the reason he didn't make his debut this year until Week 4. Reports have suggested that Godwin might not return until December, so fantasy managers who have been stashing him all this time shouldn't be surprised if he's not cleared to play this Sunday night against the Los Angeles Rams.

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Arizona Cardinals running back Emari Demercado (ankle) has been ruled out for the Week 12 contest this Sunday against the visiting Jacksonville Jaguars, head coach Jonathan Gannon said. Demercado suffered a high-ankle sprain in Week 11 and will sit out this weekend. Given the nature of the 26-year-old's injury, there's a good chance he'll miss another game in Week 13 versus the Tampa Bay Buccaneers, too. Meanwhile, Trey Benson (knee) is having his 21-day practice window opened this week, so he's nearing a return for the first time since injuring his knee in Week 4. When Demercado gets over his ankle injury, he just might be the No. 4 RB on Arizona's depth chart, so he's certainly not worth stashing in 12-team fantasy leagues. With Demercado out this week and Benson probably not ready to return yet, Bam Knight could get one more week as the RB1, with Michael Carter working on passing downs.

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Arizona Cardinals head coach Jonathan Gannon has ruled out wide receiver Marvin Harrison Jr. (appendix) for the Week 12 game on Sunday against the visiting Jacksonville Jaguars, according to Tyler Drake of Arizona Sports. Harrison had an appendectomy last week and will miss his second straight game this weekend. It remains to be seen if the 23-year-old second-year wideout will be able to return in Week 13 against the Tampa Bay Buccaneers. It's been another disappointing season for the fourth overall pick, although he has improved since quarterback Jacoby Brissett took over for the injured Kyler Murray (foot). Through nine games in 2025, Harrison has a 34-525-4 line on 62 targets. Michael Wilson, who had an incredible 15 catches for 185 yards last week with Harrison out, should once again be primed for a heavy target load in Week 12. Greg Dortch should serve as the WR2 again for Arizona, too.

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The Arizona Cardinals are opening the practice window for running back Trey Benson (knee) to return from Injured Reserve, according to Tyler Drake of AZ Sports. Benson has been on IR since Week 4 due to a knee injury. While this move does not guarantee that he will be active for Week 12 against the Jacksonville Jaguars, it's clearly a positive sign that Benson's return will come in the next few weeks. Across four games this season, the 23-year-old has recorded 224 scrimmage yards on 42 touches. With running back James Conner (ankle) out for the season, Benson profiles as the clear RB1 in Arizona once fully healthy. If Benson remains sidelined for Week 12, the Cardinals will likely turn to a combination of Bam Knight and Michael Carter to handle backfield snaps against Jacksonville.

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Atlanta Falcons head coach Raheem Morris said he's hopeful that wide receiver Drake London (knee) will be able to play in Week 13 against the New York Jets, according to Josh Kendall of The Athletic. Although the Falcons haven't officially ruled London out for their Week 12 divisional game against the New Orleans Saints this Sunday, the 24-year-old is not expected to play after spraining the PCL in his left knee in the Week 11 overtime loss to the Carolina Panthers. The good news, though, is that fantasy managers might be without London for just one game. London's fantasy stock might fall a bit with quarterback Michael Penix Jr. (knee) done for the year, but he should still be considered a must-start in all fantasy lineups when he returns from his knee sprain. With London out this weekend, Darnell Mooney and tight end Kyle Pitts Sr. should be QB Kirk Cousins' top aerial targets.

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Ryan O'Halloran of The Florida Times-Union did not list Jacksonville Jaguars running back Bhayshul Tuten (ankle) among the players who were not participating in the team's Wednesday walkthrough. Tuten was forced to exit early from his team's Week 11 win over the Los Angeles Chargers due to an ankle injury. However, his apparent on-field presence during practice on Wednesday could be a positive sign for his status in Week 12 against the Arizona Cardinals. Before leaving the game against the Chargers, Tuten was on his way to a breakout performance with 74 rushing yards and a touchdown on 15 carries. If he is active in Week 12, it's possible that Jacksonville will continue shifting touches away from veteran back Travis Etienne and towards Tuten. Fantasy managers should check back throughout the week as more information around Tuten's injury status is released.

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Atlanta Falcons quarterback Michael Penix Jr. (knee) does indeed need surgery that involves "full reconstruction" of his torn ACL and faces "at least" nine months of recovery, according to NFL Network's Ian Rapoport. Penix Jr. suffered the injury during his team's Week 11 loss to the Carolina Panthers. The injury occurred in his left knee rather than his right, which is notable considering he tore his right ACL twice during his collegiate career. A nine-month recovery timeline from late November means Penix Jr.'s availability for the start of the 2026 season could be in question. For the remainder of 2025, Atlanta will likely turn to veteran quarterback Kirk Cousins, who has struggled across three games (one start) worth of action so far this season. Cousins profiles as a low-end fantasy QB2 heading into a Week 12 matchup against the New Orleans Saints.

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Cleveland Browns head coach Kevin Stefanski said that tight end David Njoku (knee) is considered day-to-day with a knee injury and is "working hard to be able to play" in Week 12 against the Las Vegas Raiders, per Scott Petrak of BrownsZone. Across nine games this season, the 29-year-old has hauled in 30 receptions for 288 yards and three touchdowns on 45 targets. However, Njoku's usage has trended down in recent weeks, as he's hauled in just three catches for 28 yards on four targets over his last two games. If Njoku is unable to play in Week 12, it could mean a boost in playing time and target share for Browns tight end Harold Fannin Jr. Over his last five games, Fannin Jr. is averaging seven targets per game and could profile as a low-end fantasy TE1 if Njoku is out.

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Dallas Cowboys head coach Brian Schottenheimer said on Tuesday that he is "very in favor" of the team signing wide receiver George Pickens to a long-term contract extension, per Charean Williams of Pro Football Talk. The Cowboys acquired Pickens from the Pittsburgh Steelers this past offseason but have not yet locked him into a contract beyond the 2025 season. Across 10 games in his first season in Dallas, the 24-year-old has recorded 58 catches for 908 yards and seven touchdowns on 83 targets. Pickens is on pace for career-high marks across the board and appears to be the perfect complement to star Cowboys wideout CeeDee Lamb. However, Pickens has a history of off-field issues and was benched for the first offensive series of Dallas' Week 11 win over the Las Vegas Raiders for reasons that remain unclear. Still, Schottenheimer has remained effusive in his praise of Pickens and is apparently on board with continuing to work with him in the years to come.

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New York Giants quarterback Jaxson Dart (concussion) is expected to return to practice on Wednesday "in some capacity," per ESPN's Jordan Raanan. Dart suffered a concussion in Week 10 that forced him to miss New York's Week 11 loss to the Green Bay Packers. It remains to be seen whether Dart will be able to practice in full on Wednesday or if he will be limited, but either way, his presence on the field is a positive sign for his chances of playing in Week 12 against the Detroit Lions. Across nine games (seven starts) this season, Dart has thrown for 1,417 yards, 10 touchdowns, and three interceptions while rushing for 317 yards and seven scores on 57 attempts. If active, he profiles as a solid fantasy QB1 in Week 12 against Detroit. If Dart cannot return, veteran quarterback Jameis Winston would be in line to make his second straight start for the Giants on Sunday.

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Cleveland Browns rookie quarterback Shedeur Sanders is expected to start in Week 12 with Dillon Gabriel in concussion protocol. Sanders will make his first NFL start against the Las Vegas Raiders after a rough debut in Week 11, where he completed just four of 16 passes for 47 yards and an interception against the Baltimore Ravens. The matchup is far more favorable this time around, as the Raiders' defense has struggled throughout the season and was even considered a potential landing spot for Sanders during the draft process. While Sanders should draw plenty of attention as Deion Sanders' son prepares for his first start, he profiles as a low-end QB3 for fantasy purposes in Week 12.

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Buffalo Bills wide receiver Keon Coleman could be a healthy scratch again in Week 12. On the WGR550 radio show, head coach Sean McDermott didn't specify whether Coleman would play against the Houston Texans. The 2024 second-round pick has been inconsistent this season, hauling in 32 of 49 targets for 330 yards and three touchdowns in nine games. He was late to a team meeting last week, and the team decided to sit him as punishment against the Tampa Bay Buccaneers. If Coleman is out again in Week 12, Gabe Davis and Tyrell Shavers would see an uptick in volume. Fantasy managers will have to keep a close eye on this situation to see if Coleman will or will not play in Week 12.

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Buffalo Bills tight end Dalton Kincaid (hamstring) has been ruled out for Thursday night's matchup against the Houston Texans. Kincaid suffered a hamstring injury in Week 10's loss to the Miami Dolphins and will now miss his second straight game. Before going down, he was on pace for a breakout season, catching 29 of 36 targets for 448 yards and four touchdowns in just eight games. With Kincaid sidelined, Dawson Knox will handle TE1 duties, while rookie Jackson Hawes is expected to see an increased role. However, Knox managed just one catch in Week 11, making him a risky fantasy replacement. Kincaid's next chance to return will be in Week 13 against the Pittsburgh Steelers.

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Buffalo Bills second-year receiver Tyrell Shavers is coming off a breakout performance in Week 11, posting 90 yards and a touchdown on four receptions against the Tampa Bay Buccaneers. Keon Coleman's surprising healthy scratch opened the door for several Bills receivers, and Shavers took full advantage, logging a career-high 53% of the snaps. While Coleman's status for the Week 12 Thursday night matchup against the Houston Texans remains unclear, Shavers has likely earned a larger role in the offense. He isn't quite fantasy-relevant yet, but another strong showing against a tough Houston secondary could put him firmly on the radar.

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Cincinnati Bengals wide receiver Andrei Iosivas is in line for an expanded role in Week 12. Through 10 games, he's caught 19 of 35 targets for 256 yards and one touchdown, averaging 5.2 PPR points per game. With star receiver Ja'Marr Chase suspended for the week, the Bengals will lean on Tee Higgins, Iosivas, and Mitchell Tinsley to fill the void. Higgins is expected to draw coverage from Patriots shutdown corner Christian Gonzalez, along with safety help, which should leave Iosivas in more favorable matchups. As Cincinnati fights to keep its season alive, Iosivas could become a key piece of the game plan. He profiles as a high-floor fantasy option and a low-end WR3 for Week 12 against New England.

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Atlanta Falcons wide receiver Darnell Mooney is expected to see more targets moving forward. It's been a rough 2025 campaign for the sixth-year receiver, who has caught just 16 of 42 targets for 224 yards and no touchdowns in eight games. However, with Drake London (knee) likely to miss multiple weeks due to a PCL injury, Mooney should step into a much larger role. Both Brock Bowers and Ricky Pearsall dealt with PCL sprains this season and missed four or more weeks. With Michael Penix Jr. (knee) out for the season, Kirk Cousins will take over at quarterback and could lean on Mooney heavily, like he did at times in 2024. Mooney now projects as the top option in the passing game and should be one of the most popular waiver-wire adds this week.

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Jacksonville Jaguars rookie running back out of Virginia Tech, Bhayshul Tuten (ankle), exited during the third quarter of Sunday's Week 11 contest against the Los Angeles Chargers with an ankle injury and didn't return. Important to note: he mentioned in an interview with Jamal St. Cyr, Sports Anchor for News4JAX, that his ankle is "good." Now, players are usually going to always say things like that, especially after a career day where he appeared to be in a 50/50 split with Travis Etienne from the first snap of the game for the first time all season. Regardless, Tuten was one of the most prized possessions on the waiver wire this week, and for good reason; he averaged a healthy 4.93 YPC in Week 11 and looked really efficient, breaking tackles and racking up yards after contact. With ETN in the picture, it's unlikely that Tuten will take over the backfield; however, moving forward, this may be more of a 50/50 split, giving both running backs low-end RB2 status. Fantasy managers will want to keep tabs on Tuten's practice logs this week, as they prepare to take on the Arizona Cardinals, who rank in the bottom 10 in fantasy points allowed to the running back position.

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Pittsburgh Steelers running back Kenneth Gainwell has emerged as a reliable backup running back this season. Through 10 games, he's totaled 448 yards and five touchdowns on 97 touches. He's been strong in the two games where starter Jaylen Warren either missed or exited early, racking up 239 scrimmage yards and four touchdowns on 41 touches. With Warren still banged up and an ideal Week 12 matchup on deck against the Chicago Bears, Gainwell could be in line for another heavy workload. Given how efficient he's been both in his backup role and starting role, fantasy managers should view Gainwell as one of the top handcuff running backs to target moving forward.

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Tampa Bay Buccaneers running back Sean Tucker exploded in Week 11 with 140 all-purpose yards and three touchdowns. He out-touched backfield mate, Rachaad White, 19-10, and has looked like the better, more efficient runner the past few weeks. Head coach Todd Bowles mentioned on Monday that "it's hard to say" if running back Sean Tucker will see more playing time even when Bucky Irving (foot, shoulder) comes back, according to the Pewter Report. It appears the Bucs may go with a hot-hand approach in the backfield while Irving remains out. Regardless, this Week 12 matchup is brutal for whoever the Bucs plan to roll out there. The Los Angeles Rams are tough against opposing running backs, ranking third overall in the fewest points allowed to the position. The positives for Tucker are that he may have overtaken White's early-down work, and, as a result, Tucker will remain in the RB3/flex conversations this week, assuming Irving is still not able to play. If Irving does play, Tucker should remain on fantasy managers' benches.

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