Pittsburgh Steelers safety DeShon Elliott (knee) and defensive tackle Derrick Harmon (knee) will both miss the Week 2 contest this Sunday against the Seattle Seahawks, according to head coach Mike Tomlin. Harmon will miss his second straight game to begin the year after h was inactive for the season-opening win on Sunday against the New York Jets. Elliott injured his left knee in Week 1 in the second quarter and did not return. With the 28-year-old defensive back unavailable for Week 2, expect Chuck Clark to make the start across from Juan Thornhill against Seattle. Elliott and Harmon will be hoping to heal up and be ready to play in a Week 3 matchup on the road against the New England Patriots on Sunday, Sept. 21. Fantasy managers are going to be a little more wary of starting Pittsburgh's defense in Week 2 after they allowed over 30 points in the season opener to the Jets.

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After watching how the Washington Commanders used new wide receiver Deebo Samuel Sr. in the Week 1 win over the New York Giants, The Athletic's Nicki Jhabvala writes that it's clear the team wants him to "be everywhere" and to "do everything." Samuel played 54 offensive snaps and caught seven of a team-high 10 targets for 77 yards. Most of his snaps (74.5%) and targets (six) cam from the slot, but the 29-year-old also lined up out wide and in the backfield. He had a 19-yard rushing touchdown and was used on three WR screens. With the 49ers, Samuel was a deep target around only eight times per year. But in Week 1 on Sunday he was targeted deep twice. He was also Washington's lead returner on kickoffs. It's no secret now that the Commanders plan to use Samuel a lot, and in all situations. It will leave him more vulnerable to injury, but it will also rejuvenate his fantasy appeal.

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With the Jacksonville Jaguars trading Tank Bigsby to the Eagles on Monday, their running depth chart gained a little breathing room. The team now lists Travis Etienne Jr., Bhayshul Tuten, and LeQuint Allen Jr. on the active roster, and if Sunday's matchup against the Panthers is any indication, Allen could find himself involved in the passing game. Seven of Allen's nine snaps on Sunday came on passing plays, earning one target, which he caught for four yards. Bhayshul Tuten saw the field only four times, but not once when Trevor Lawrence dropped back to pass. Bigsby was the back on eight passing plays, but with him now shipped to Philadelphia, an opportunity exists for Allen to carve out a greater role on passing downs. One of the most prolific collegiate pass catchers in his rookie class, it should come as no surprise if he's able to turn those looks into tangible plays, and he has contingent upside should anything happen to Etienne. As such, Allen is worth a claim in deep leagues.

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With the San Francisco 49ers placing All-Pro tight end George Kittle (hamstring) on the IR on Tuesday, the team is left with only Luke Farrell and Jake Tonges at the position. While fullback Kyle Juszczyk could be asked to handle an expanded role, it was the fourth-year tight end Tonges who stepped in on Sunday following Kittle's departure due to a hamstring injury. Tonges made the first three catches of his NFL career, including a 4-yard TD pass with under two minutes to play. With quarterback Brock Purdy (shoulder, toe) and wide receiver Jauan Jennings (shoulder) also banged up, the 49ers' offense may look entirely different heading into Week 2. While the gameplan will continue to be funneled directly through Christian McCaffrey, the team will be looking for contributions wherever they can get them, and Tonges could be in line for his first career start. While his effectiveness could be capped in a Mac Jones offense, desperate managers can throw a waiver dart in hopes of volume by necessity.

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Going into the season as a fantasy afterthought, Pittsburgh Steelers veteran Kenneth Gainwell was the running back on the field for the majority of his team's Week 1 snaps. In a back-and-forth matchup with the New York Jets, Gainwell saw 29 snaps to Jaylen Warren's 25. While Warren did lead the position in carries and total opportunities, most expected his split to be with rookie Kaleb Johnson and not the journeyman Gainwell. In speaking with reporters on Tuesday, head coach Mike Tomlin suggested that Gainwell could continue to see the field moving forward, citing the big-play ability he's shown throughout his career. While Gainwell deserves a look on the waiver wire by any managers hit hard by injury in Week 1, the expectation is still that the third-rounder Johnson, who saw only one snap in his NFL debut, will be worked into the offense, shortening Gainwell's fantasy shelf life considerably.

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Broncos running back RJ Harvey is one of five offensive players nominated as Rookie of the Week following the first game of his NFL career. Harvey was used sparingly in the Broncos' Week 1 victory over the Titans, carrying the ball only six times. However, he was able to turn those six carries into 70 yards, aided by a 50-yard run in the 4th quarter. Comparatively, J.K. Dobbins took 16 carries for 63 yards and a touchdown. Should Harvey continue to display the explosiveness he showed in helping to seal away the game, it won't be long until he's given a larger role. Until that happens, he can be started in the flex spot for managers with no better options, but those who can remain patient should be rewarded in the near future.

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San Francisco 49ers TE George Kittle (hamstring) has been placed on injured reserve and will miss a minimum of four weeks.

Fantasy Spin: Luke Farrell stepped up as the primary tight end in the 49ers' offense in Kittle's absence on Sunday. He didn't emerge as a primary target in the offense, so he should not be a focus in your league despite the opening in the San Francisco offense.

From TheHuddle

Philadelphia Eagles running back Will Shipley (rib) reportedly suffered a fractured rib in the season-opening win over the Dallas Cowboys last Thursday, according to sources. This makes Monday's acquisition of RB Tank Bigsby from the Jacksonville Jaguars make more sense, but in addition to depth behind starter Saquon Barkley, Bigsby can also help the Eagles out on special teams as a kickoff returner. It's unclear how much time Shipley will miss, but he probably will not be able to suit up in Week 2 in a Super Bowl rematch against the Kansas City Chiefs, and when he does return, he may no longer be the direct backup to Barkley. The 23-year-old only carried the ball three times for 26 yards in Week 1 before he suffered his fractured rib on a kick return late in the first half. In addition to Bigsby, the Eagles have AJ Dillon as backfield depth.

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According to Adam Schefter of ESPN, the San Francisco 49ers are placing tight end George Kittle (hamstring) on the injured reserve. As a result, Kittle will miss at least the next four games. The star tight end suffered this injury during their Week 1 victory over the Seattle Seahawks. Before exiting the contest, Kittle caught all four of his targets for 25 yards and a touchdown. When he was sidelined, Kittle was replaced by Luke Farrell and Jake Tonges. Fantasy managers should continue to monitor his status, but it appears he will be sidelined for at least the next month. While he remains out, fantasy managers should expect Farrell to see most of the blocking work while Tonges takes on most of the receiving work. Tonges caught all three of his targets for 15 yards and appears to be in the lead role to take on most of Kittle's offensive production. He is worth targeting in deep 14+ team formats on the waiver wire.

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The San Francisco 49ers are waiving kicker Jake Moody on Tuesday, a source told Tom Pelissero of NFL Network. Moody made 84 percent of his 25 field-goal attempts and led the league with 60 extra points made in his rookie campaign in 2023, but it quickly went downhill for him from there. The 25-year-old struggled in the postseason in 2023 and then made only 24 of his 35 field-goal tries in 14 games in his sophomore season a year ago. Moody then made just one of his three field-goal attempts (one was blocked) in the Week 1 win over the Seattle Seahawks on Sunday to seal his fate in the Bay Area. He will now attempt to latch on with another team heading into Week 2. The Niners don't currently have another kicker on their roster, so they will be working out options this week to kick for them in Week 2 against the New Orleans Saints.

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New England Patriots tight end Hunter Henry didn't wow anyone with his production in the Week 1 loss to the Las Vegas Raiders, but what did stand out was that he played 93 percent of the offensive snaps and was tied for the team lead in targets with Kayshon Boutte with eight. Henry hauled in four of his eight targets for 66 yards, which was second on the team behind Boutte's 103 receiving yards. If you are already streaming tight ends going into Week 2 or just lost George Kittle (hamstring) for three to five weeks, Hunter is absolutely worth looking at on the waiver wire going into a Week 2 meeting against a Miami Dolphins defense that just gave up 33 points to Daniel Jones and the Indianapolis Colts. Austin Hooper was only on the field for 23 snaps and caught one pass for 10 yards. Henry is currently rostered in 59 percent of Yahoo leagues.

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Arizona Cardinals running back James Conner unsurprisingly led the team's backfield in their Week 1 win over the New Orleans Saints with 12 carries, but he averaged only 3.3 yards per carry for 39 total rushing yards. Meanwhile, backup Trey Benson handled eight carries for 69 yards -- 75 percent of his production came on one run -- and also caught his only target for a six-yard pickup. If Week 1 was any indication, the backfield split in Arizona could be more even than most fantasy managers expected going into the year, which is reason enough to pick Benson up off the waiver wire. The 23-year-old back is currently only rostered in 39 percent of Yahoo leagues, making him a prime waiver-wire priority for those that are already looking at a thin RB situation. Benson and the Cardinals also have a juicy Week 2 matchup against a bad Carolina Panthers defense.

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Houston Texans running back Nick Chubb didn't exactly turn heads in the team's Week 1 loss to the Los Angeles Rams, but he was the clear RB1 in Houston's backfield with Joe Mixon (ankle, foot) out. Chubb handled 62 percent of the running back carries on Sunday against the Rams and led the Texans in rushing attempts (13) and rushing yards (60). He wasn't able to haul in his lone target in the 14-9 loss. The 29-year-old four-time Pro Bowler may never be as dominant as he once was with the Cleveland Browns before he suffered a gruesome knee injury in 2023, but the opportunity is there for him to be the team's bell-cow back for a good portion of the 2025 season. Right now, he's currently rostered in only 68% of Yahoo leagues, so if you're in a pinch early on at the RB position, you should be looking at scooping Chubb off the waiver wire.

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Jackonville Jaguars quarterback Trevor Lawrence had an encouraging first-half showing in the Week 1 win over the Carolina Panthers, going 14-for-19 for 128 yards and a touchdown, but the Jags had a 20-3 lead at halftime and chose to go conservative in the second half. Lawrence finished 19-for-31 passing on the day for 178 yards, a touchdown and an interception, so overall, his day didn't look all that great against a team that had the worst defense in the league in 2024. This game also included a lengthy weather delay that could have interrupted the 25-year-old's rhythm in head coach Liam Coen's first game. While Lawrence' final stat line didn't jump off the page, he could be primed for a much better performance in a Week 2 date against a Cincinnati Bengals defense that was quite porous last year.

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Atlanta Falcons wide receiver Darnell Mooney (shoulder) did not play in Week 1 due to a shoulder injury he suffered during training camp. However, Mooney was listed as questionable coming into the game on Sunday and could be a player for fantasy managers to target heading into Week 2. Top Falcons wide receiver Drake London (shoulder) sprained his shoulder in Week 1 and is considered day-to-day due to the injury. If London were to end up missing Week 2 and Mooney were to return, Mooney would be the clear top wide receiver target for Falcons quarterback Michael Penix Jr. Penix Jr. attempted 42 passes and threw for 298 yards in Week 1, so even if London is healthy, Mooney should have a chance to play a fantasy-relevant role. Where available, he should be added in all fantasy leagues with 10 or more teams.

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Miami Dolphins wide receiver Tyreek Hill's estranged wife has alleged in court filings that Hill committed domestic violence, although he has vehemently denied the allegations. Keeta Vaccaro has alleged eight separate incidents of domestic violence that were related to the couple's divorce, according to documents obtained by TMZ. Vaccaro alleges the first incident happened in January of 2024, about two months after they were married. Hill's attorney said that the allegations are part of a "shakedown" and are "an attempt to generate bad media coverage" for his client. He has not formally been criminally charged, and it's unclear if law enforcement was investigating Vaccaro's allegations. The five-time All-Pro was detained by police last September after being stopped for reckless driving as well. It's unclear if this situation will lead to a potential suspension from the NFL, but it's one more thing to worry about for Hill's fantasy managers after Miami's offense looked bad again in a Week 1 blowout loss to the Colts.

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The Atlanta Falcons are signing kicker Parker Romo to their practice squad, per Tom Pelissero of NFL Network. Current Falcons kicker Younghoe Koo had a rough game in Week 1 against the Tampa Bay Buccaneers, missing a 44-yard field goal attempt that would have tied the game with under five seconds to go. Romo appeared in four games for the Minnesota Vikings in 2024, making 11 of his 12 field goal attempts and seven of eight extra-point attempts. Koo does not appear to have lost his job yet, but Atlanta has now brought in some competition in case he falters in a critical late-game situation again.

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Kansas City Chiefs wide receiver Marquise Brown could be in line for a significant target volume going forward, given the current state of the team's wide receiver room. Top wideout Rashee Rice will miss the first six games of the season due to suspension, and WR2 Xavier Worthy (shoulder) is week-to-week after dislocating his shoulder in Kansas City's season opener. Without Worthy and Rice on the field, Brown was targeted sixteen times in Week 1, recording 10 catches for 99 yards. The 28-year-old Brown should be added in all leagues and could be a must-start wide receiver in Week 2 against the Philadelphia Eagles if Worthy is unable to play.

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Los Angeles Chargers wide receiver Quentin Johnston put up a big performance in Week 1 against the Kansas City Chiefs, recording five catches for 79 yards and two touchdowns. Johnston is a priority waiver-wire pickup for fantasy managers heading into his Week 2 matchup against the Las Vegas Raiders. The 24-year-old has been an inconsistent player through his first two-plus NFL seasons, but he's still a former first-round pick with high-upside physical traits. With 10 touchdowns in his last 16 games played, Johnston has also proven to be a solid end-zone target for Chargers quarterback Justin Herbert. Johnston should be added in all fantasy leagues with 10 or more teams.

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Veteran safety Jabrill Peppers is expected to sign with the Pittsburgh Steelers, according to Ian Rapoport of NFL.com. Steelers safety DeShon Elliott (knee) left the team's Week 1 matchup early due to a knee injury, so Peppers could be coming in as Elliott's replacement. The 29-year-old Peppers is entering his ninth NFL season. In six games with the New England Patriots last season, he recorded 20 solo tackles and one interception.

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