San Francisco 49ers quarterback Brock Purdy is in line for another strong showing in Week 16 when he takes on the Indianapolis Colts on Monday night. The Colts' defense will be a tougher test than he saw against Tennessee last week, but there is room for optimism. Indianapolis has allowed the third most passing yards this season, and over their last four games, they have given up an average of 286.5 yards per game. Purdy may be missing a weapon if Ricky Pearsall (knee/ankle) is held out, but he will have the trio of Christian McCaffrey, Jauan Jennings, and George Kittle at his disposal. Purdy projects as a QB1 for the semifinal round of the fantasy football playoffs and can be plugged into starting lineups.

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San Francisco 49ers running back Christian McCaffrey will put a four-game touchdown streak on the line in Week 16 against the Colts. Last week, Indianapolis held Seahawks running backs Kenneth Walker III and Zach Charbonnet out of the end zone, but had given up at least one rushing touchdown to a running back in each of their six previous games. McCaffrey appears to be clear of the back injury that made him a surprising late addition to the 49ers' injury report last week, and should see plenty of work on Monday night. If Ricky Pearsall (knee/ankle) is unable to play, then CMC would likely reemerge as a candidate to lead the team in targets, as he has done six times already in 2025. Fantasy football managers should watch for the 49ers' final injury report, but assuming McCaffrey is fully healthy, he has the potential for a top-3 finish at his position.

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San Francisco 49ers wide receiver Jauan Jennings tallied two more touchdowns in Week 15 but again turned in a low-yardage game with just 37 yards against the Titans. Jennings has at least one touchdown in five of the 49ers' last six games, but is averaging 47.2 yards per game during that stretch. He could be in store for a more productive day in Week 16, when San Francisco faces the Indianapolis Colts, which has surrendered more receiving yards to slot targets than any other team. Jennings has played out of the slot more frequently than any other receiver for San Francisco this season. If Ricky Pearsall (knee/ankle) is unable to play, then Jennings would likely see a slight bump in targets on Monday, as well. Jennings projects as a WR2 and can be plugged into starting lineups in Week 16.

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New England Patriots tight end Hunter Henry is coming off one of his worst games of the season: a one-catch, 18-yard outing against the Buffalo Bills. On one hand, it seems like Henry can only go up from here. On the other hand, he could struggle in a very challenging Week 16 matchup against the Baltimore Ravens. The Ravens' defense has allowed the third-fewest touchdowns and fourth-fewest fantasy points to opposing tight ends in 2025. Just last week, they limited Cincinnati's Mike Gesicki to just one catch for 11 yards. In addition to the tough matchup, Henry will face competition for targets from wide receivers Stefon Diggs, Kayshon Boutte, and Mack Hollins, especially with Baltimore struggling against perimeter receivers. He'll also lose opportunities to fellow tight end Austin Hooper and the Patriots' backfield. If this were a more favorable matchup, managers could feel good about Henry's potential to separate himself from the rest of the pass-catchers and turn in a big week. However, the Ravens don't offer much of a chance for the veteran tight end to get right. He's borderline benchable this week and ranks as the overall TE13 in RotoBaller's latest fantasy football rankings.

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New England Patriots wide receiver Kayshon Boutte had a disappointing performance last Sunday against the Buffalo Bills (one catch for 30 yards), but he should bounce back against the Baltimore Ravens on Sunday Night Football in Week 16. Despite his reduced volume and productivity lately, Boutte has played at least 75% of the offensive snaps in each of his last three games. He consistently gets onto the field and runs routes. Now, he just needs a steadier target share. That could come to fruition this week against the Ravens. Of all the fantasy points that Baltimore has surrendered to wide receivers in 2025, 69% of those points have been recorded by receivers who play on the perimeter. That mark ranks ninth-highest in the NFL, and it bodes well for Boutte, who almost always operates out wide. He and Mack Hollins, who also frequents the perimeter, should benefit from this matchup. Boutte currently ranks as the WR55 in RotoBaller's Week 16 fantasy football rankings, but managers in leagues with 14+ teams could certainly justify starting him as a low-floor, high-ceiling WR3 or flex on Sunday night.

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New England Patriots wide receiver Mack Hollins has another opportunity to produce as a solid flex play in fantasy football ahead of Sunday Night Football against the Baltimore Ravens in Week 16. Hollins has been heavily involved in the Patriots' offense, averaging six targets and 9.2 full-PPR fantasy points over his last seven contests. During that span, he ranks as the overall WR40. He has also played at least 75% of the offensive snaps in each of his last five games. As a result, he has been getting more involved than Stefon Diggs and has similar participation to Kayshon Boutte. Last week against the Buffalo Bills, Hollins totaled 136 air yards, which ranked eighth-most among all NFL receivers. Quarterback Drake Maye trusts Hollins as one of his most reliable receivers, and his specific role bodes well for his Week 16 outlook. Of all the fantasy points that Baltimore has surrendered to wide receivers in 2025, 69% of those points have been recorded by receivers who play on the perimeter. That mark ranks ninth-highest in the NFL, and it bodes well for Hollins, who has played 77.3% of his snaps out wide. Hollins isn't the flashiest name, but his role, consistency, reliability, and involvement make him a solid WR3/flex play for Week 16. He ranks as the overall WR46 in RotoBaller's latest fantasy rankings.

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New England Patriots wide receiver Stefon Diggs will look to get back on track in Week 16 against the Baltimore Ravens following a disappointing three-game stretch. Over his last three contests, Diggs has played fewer than half of the offensive snaps with just 11 targets, eight catches, 72 yards, and zero touchdowns. He ranks as the overall WR82 in full-PPR fantasy points per game during that span. It has been a frustrating stretch for a veteran receiver who had previously strung together five consecutive contests with double-digit fantasy points. This week, he'll take on a Ravens secondary that has allowed the ninth-fewest fantasy points to slot receivers in 2025. That doesn't bode well for Diggs, who has played 49.8% of his snaps in the slot and has the 19th-most slot snaps in the NFL this year. Managers can absolutely justify benching the 32-year-old in fantasy leagues with 12 or fewer teams. He ranks as the overall WR31 in RotoBaller's latest fantasy football rankings for Week 16.

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Cincinnati Bengals wide receiver Ja'Marr Chase has certainly had his share of ups and downs throughout the 2025 campaign. He hasn't scored a touchdown in weeks. Still, the wideout remains involved at a high level, most recently catching 10 of his 16 targets for 132 yards in the Week 15 AFC North clash with the Baltimore Ravens. The Bengals aren't going to the postseason. However, as long as Chase is active, there's no way fantasy managers can keep him on the bench and feel good about it. That applies to Sunday's meeting with the Miami Dolphins, even more so if Tee Higgins (concussion) misses another contest.

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Cincinnati Bengals running back Chase Brown struggled on the ground in the last three games. However, he at least made up for it by catching 17 passes during that span. Without question, fantasy managers were expecting more from the 25-year-old after a quality 2024 campaign. Still, the upside is there, as evident by his two-touchdown effort in the Week 14 loss to the Buffalo Bills. The Bengals have already been eliminated from postseason contention. While that could result in Brown and some of the other starters shutting it down before the end of the regular season, he should handle his usual workload versus Miami in Week 16, keeping him in the must-start conversation. That applies even more for PPR participants if Tee Higgins (concussion) can't suit up, considering Brown will presumably remain in line for additional pass-catching opportunities.

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Cincinnati Bengals quarterback Joe Burrow (knee) popped up on the injury report to begin the practice week. Fortunately, he logged full sessions and doesn't carry an injury designation for Sunday's game against Miami. The signal-caller completed only 52.2% of his attempts in the Thursday night win over Baltimore in Week 13, although he still tossed two touchdowns to make up for it. However, it was a different story in the Week 15 rematch, with Burrow throwing two picks while failing to connect with any of his receivers in the end zone. The Bengals aren't going to the postseason, but that shouldn't stop the 2020 No. 1 overall pick from trying to lead his squad to wins to close out the 2025 campaign. With the Dolphins also eliminated from playoff contention, both teams have nothing to lose in Week 16. All things considered, as long as Burrow is active, he remains a must-start in any fantasy setup, even if Tee Higgins (concussion), who is questionable, can't suit up.

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New England Patriots running back TreVeyon Henderson has been one of the most explosive players in football since taking over as the team's primary ball-carrier in Week 9. Since that Week 9 contest, he ranks as the overall RB4 in full-PPR fantasy points per game, and he's averaging a whopping 6.2 yards per carry. He also has 18 catches over his last six games. Most recently, the rookie out of Ohio State gashed the Buffalo Bills for 148 rushing yards and two touchdowns. He should remain an explosive, high-ceiling running back ahead of Sunday Night Football against the Baltimore Ravens in Week 16. The Ravens have been particularly susceptible to pass-catching running backs, which bodes well for Henderson given that he's averaging three catches per game since taking over the reins in New England. Even though Rhamondre Stevenson continues to steal 5-10 touches every week, there's no question that this backfield belongs to Henderson. The 23-year-old should continue to be started in all fantasy leagues. He ranks as the overall RB14 in RotoBaller's Week 16 fantasy rankings, and he has top-10 upside.

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After recording touchdown catches in back-to-back games in Weeks 13 and 14, Detroit Lions wide receiver Isaac TeSlaa was held without a reception on just one target in Week 15 by the Los Angeles Rams. The 23-year-old saw a reduction in playing time thanks to the return of Lions wideout Kalif Raymond, who had missed each of Detroit's previous two games with an ankle injury. On the bright side, TeSlaa still played 63% of his team's offensive snaps in Week 15, which was his third-highest mark in any game this season. However, he's recorded just eight catches on 15 targets across 14 games in 2025 and has been unable to carve out a consistent role in the Lions' passing game. The Lions have a favorable matchup on paper in Week 16 against the Pittsburgh Steelers, who currently rank 29th in the NFL in total passing yards allowed (3,649). Still, TeSlaa's inconsistency makes him very difficult for fantasy managers to trust, and he should likely remain off fantasy radars in Week 16.

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Detroit Lions kicker Jake Bates has been a bit shaky in recent weeks, as he's recorded a missed field goal in each of Detroit's last two games. He's now missed six field goal attempts across 14 games this season after missing just three attempts across 17 games as a rookie in 2024. Still, Bates leads the NFL in both extra-point makes (49) and attempts (51). He remains attached to the Lions offense, which enters Week 16 averaging a league-leading 30.6 points per contest. In Week 16, Detroit will host the Pittsburgh Steelers. Pittsburgh currently ranks just 18th in points allowed per game (23.3), so Detroit could have opportunities to get Bates on the field in point-scoring situations. Additionally, the game will be held indoors at Detroit's Ford Field, so the weather will not be a factor. Bates profiles as a solid starting kicker option for fantasy managers in Week 16.

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Pittsburgh Steelers tight end Pat Freiermuth caught three of his five targets for 45 yards last Monday night against the Miami Dolphins, but he was still out-snapped by tight end Darnell Washington and out-performed by tight end Jonnu Smith. Washington played 73% of the offensive snaps in Week 15, which was the fourth time in his last five games that he saw the field for at least two-thirds of the plays. The 24-year-old is only the TE38 in PPR leagues this year, but he has been a major part of the Steelers' offense with his ability to set huge blocks, catch short passes, and use his physical strength to earn yards after the catch. Meanwhile, Smith only played 29% of the snaps last week, but he continues to get involved in playcaller Arthur Smith's offense. On Monday, the tight end had two catches and a rushing touchdown. There's a role for every tight end in this offense, including Freiermuth, who is the TE25 in PPR leagues with 31 catches, 352 yards, and four touchdowns this year. However, none of the trio can be trusted in fantasy football leagues over the final stretch of the 2025 season. As it stands, Freiermuth is ranked as RotoBaller's TE29 ahead of his Week 16 clash with the Detroit Lions.

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After missing two games with an ankle injury, Detroit Lions wide receiver Kalif Raymond returned to the lineup in Week 15 against the Los Angeles Rams and recorded one catch for 20 yards on one target. Despite his return, the 31-year-old saw a significant drop in playing time. Raymond played just 11 offensive snaps in Week 15, his first time playing fewer than 27 snaps in a game he was active for since Week 6. The veteran may be seeing his playing time usurped by rookie Lions wideout Isaac TeSlaa, who hauled in touchdown grabs in both games that Raymond missed with the ankle issue. For the season, Raymond has recorded just 16 catches for 170 yards on 20 targets across 12 games. Even in a favorable matchup on paper against the Pittsburgh Steelers in Week 16, he remains an unlikely candidate for production. Raymond should remain off the radar of fantasy managers in Week 16.

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Las Vegas Raiders tight end Michael Mayer remains off the fantasy radar ahead of Week 16 against the Houston Texans. Mayer was productive during his short stint as the team's starting tight end earlier this season, but he fell off the fantasy radar when superstar tight end Brock Bowers returned to the mix mid-year. Mayer has dealt with his own injury problems, too, as the 24-year-old was sidelined for Weeks 13 and 14. In his return to action last week, he played just 19% of the offensive snaps and wasn't targeted in Vegas' Kenny Pickett-led offense. Geno Smith will return as the Raiders' starting quarterback this upcoming Sunday, but that shouldn't change Mayer's fantasy outlook much. He is averaging just 2.0 catches, 15.3 yards, and zero touchdowns in games where Bowers is active.

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Tennessee Titans running back Tyjae Spears has dealt with a reduced role lately as Tony Pollard earns a heavy dose of touches. Pollard was relatively disappointing from Week 5, when Spears returned from injured reserve, through Week 13. However, in Week 14, he broke out against a relatively strong Browns run defense, and he had another big showing last Sunday against the San Francisco 49ers. Through those two games, Pollard has totaled an absurd 265 rushing yards and three rushing touchdowns on 39 carries. As a result of his teammate's sudden breakout, Spears has been left in nothing more than a change-of-pace role. In his last two games, Spears has just 11 carries for 53 yards. He has two catches in each of those contests, setting a new season-low mark. We expect that this backfield will belong to Pollard once again in Week 16 against the Chiefs, leaving Spears off the fantasy radar. He ranks as the overall RB50 in RotoBaller's fantasy rankings for Week 16.

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After a slow start to the 2025 season, Detroit Lions wide receiver Jameson Williams has exploded over the second half of the year. Across his last seven games, the 24-year-old has recorded 647 receiving yards and five touchdown catches. After earning more than seven targets just once over the season's first 12 weeks, he's been targeted by Lions quarterback Jared Goff at least nine times in three straight games. Williams could have a chance to continue his emergence in Week 16 against the Pittsburgh Steelers, who profile as a favorable matchup on paper. Entering the week, Pittsburgh ranks 29th in the NFL in total receiving yards allowed (3,649). With Lions tight end Sam LaPorta (back) on Injured Reserve, Williams has emerged as the team's clear number two option in the passing game alongside wideout Amon-Ra St. Brown. Williams profiles as a low-end fantasy WR1 with high-end upside in Week 16.

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Detroit Lions wide receiver Amon-Ra St. Brown had a monster game in Week 15, recording 13 receptions for 164 yards and two touchdowns on 18 targets against the Los Angeles Rams. The 26-year-old has earned double-digit targets in seven out of 14 games this season and ranks second in the NFL with 11 touchdown grabs. In Week 16, St. Brown gets a favorable matchup on paper against the Pittsburgh Steelers. Entering the week, Pittsburgh ranks 29th in the NFL in passing yards allowed (3,649). The Lions have also been trending towards a more pass-heavy offense in the second half of the season, as quarterback Jared Goff has attempted at least 33 passes in six out of the team's last seven games. Given the combination of likely target volume and his opponent, St. Brown could be in for another big performance and profiles as a must-start fantasy wide receiver in Week 16.

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Detroit Lions running back Jahmyr Gibbs had a disappointing game in Week 15 against the Los Angeles Rams, totaling just 58 scrimmage yards and failing to reach the end zone on 17 touches. On the bright side, the 23-year-old continues to feature heavily in the Detroit passing game. Gibbs earned seven targets in Week 15 and has seen 38 targets across five games since Lions tight end Sam LaPorta (back) was placed on Injured Reserve with a back injury. In Week 16, Gibbs and the Lions will host the Pittsburgh Steelers. Pittsburgh's defense profiles as a mid-pack unit against the run, ranking 19th in the NFL in total rushing yards allowed (1,692). Gibbs should continue to see a heavy volume of touches as both a rusher and a receiver, and his big-play ability allows for explosive upside. Fantasy managers can view Gibbs as a must-start running back in Week 16.

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