Buffalo Bills head coach Sean McDermott said that running back James Cook (ankle, foot) will not practice on Wednesday due to an ankle/foot injury, according to Katherine Fitzgerald of The Buffalo News. Cook had another nice game in the team's Week 9 victory over the Kansas City Chiefs, carrying the ball 27 times for 114 yards while also catching one pass for 11 yards. However, the 26-year-old apparently came out of that game a little gimpy, and his status is now up in the air for the team's Week 10 tilt on the road against the division-rival Miami Dolphins. If Cook were to miss this weekend, Ty Johnson and Ray Davis would likely split backfield duties for the Bills in a great matchup. Cook has been a must-start RB1 every week in 2025, as he's currently the RB7 in fantasy in half-PPR scoring with 867 rushing yards and seven touchdowns on 153 carries.

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Cleveland Browns rookie quarterback Shedeur Sanders (back) will return to practice on Wednesday from the back injury that sidelined him in Cleveland's most recent game against the New England Patriots. It appears Sanders is on track to be active for the Browns' Week 10 matchup against the New York Jets. If he's healthy enough to play in Week 10, Sanders would likely be the backup to fellow rookie quarterback Dillon Gabriel. For now, Sanders is still waiting on an opportunity to make his NFL debut. Across six games (four starts), Gabriel has completed 59.9% of his pass attempts for 702 yards, five touchdowns, and two interceptions. Despite the modest production, there's been no indication out of Cleveland that the team is currently considering replacing Gabriel with Sanders any time soon.

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Indianapolis Colts head coach Shane Steichen said that newly acquired cornerback Sauce Gardner (concussion) is in the league's concussion protocol, but he will practice on Wednesday, according to Mike Chappell of FOX 59. The Colts gave up a lot to secure the services of the All-Pro corner at the trade deadline on Tuesday, giving up receiver Adonai Mitchell and two first-round picks. Gardner is still in the concussion protocol despite coming off a bye last week, but the fact that he's going to practice on Wednesday means he has a chance to make his debut with the Colts this Sunday in Berlin, Germany, against the Atlanta Falcons. The Colts are 7-2 and tied for the best record in the AFC heading into Week 10, but their secondary has been a weak spot so far this year. Gardner will definitely shore up their secondary as one of the best cover corners in the NFL.

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Jaguars reporter Ryan O'Halloran of The Florida Times-Union said on a recent radio appearance that the price the team paid to acquire wide receiver Jakobi Meyers indicates that the team views him as more than just a rental. Jacksonville traded fourth and sixth-round draft picks to the Las Vegas Raiders in exchange for Meyers on Tuesday. Meyers will provide immediate aid to a Jaguars wide receiver room that will be without Travis Hunter (knee) for at least three more games and could be without both Brian Thomas Jr. (ankle) and Dyami Brown (concussion) in Week 10. Meyers recorded 33 catches for 352 yards and zero touchdowns on 49 targets across seven games for Las Vegas this season. If O'Halloran is correct and Jacksonville plans to keep Meyers beyond 2025, his presence could be a slight negative for the dynasty value of Hunter and Thomas Jr.

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Cleveland Browns rookie wide receiver Isaiah Bond (foot) is dealing with a foot injury that is expected to keep him from practicing on Wednesday, per ESPN's Daniel Oyefusi. Bond's availability for his team's Week 10 matchup against the New York Jets appears to be in jeopardy. The 21-year-old has recorded 11 catches for 123 yards on 30 targets across eight games so far this season. However, he was held without a catch on four targets in his final two games before the Browns' Week 9 bye. If Bond is sidelined in Week 10, wide receiver Jerry Jeudy and tight ends David Njoku and Harold Fannin Jr. could see a slight bump in target share. Additionally, wide receiver Cedric Tillman (hamstring) could make his return in Week 10 from a hamstring injury that has sidelined him since Week 4. Even if Bond can play, he should likely remain off fantasy radars in Week 10 against New York.

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Tampa Bay Buccaneers wide receiver Chris Godwin (leg) is not expected to practice on Wednesday, per Rick Stroud of the Tampa Bay Times. Godwin missed the team's final three games before their Week 9 bye due to a leg injury, and it appears he may not be ready to return in Week 10 against the New England Patriots. It's beginning to look like somewhat of a lost season due to injury for Godwin, who also missed Tampa Bay's first three games of 2025 while recovering from the dislocated ankle that ended his 2024 season. In the two games he's played this season, Godwin has recorded six catches for 52 yards on 14 targets. If he remains sidelined in Week 10, Buccaneers rookie wideout Tez Johnson could maintain a sizable role in the team's offense. Johnson has recorded 10 catches for 146 yards and two touchdowns on 18 targets over his last three games played. Veteran wideout Sterling Shepard and tight end Cade Otton are also candidates to be the team's number two pass-catcher behind star wide receiver Emeka Egbuka.

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Indianapolis Colts wide receiver Alec Pierce has almost exclusively been known as a downfield pass-catcher throughout his career. Across his first three NFL seasons, Pierce averaged 4.3 targets per game and 17.6 yards per reception. Now in his fourth season, Pierce is still making big plays. However, there are signs that Indianapolis is viewing him as a more well-rounded wide receiver. Through his first seven games played in 2025, Pierce is averaging 6.4 targets per contest. He's been particularly involved in recent weeks with 28 targets over his last three games played. Pierce has yet to find the end zone this season, but he scored seven touchdowns across 16 games in 2024. Heading into a Week 10 matchup against the Atlanta Falcons, Pierce should be rostered in all fantasy leagues with 12 or more teams.

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Tampa Bay Buccaneers running back Bucky Irving (foot, shoulder) is not expected to practice on Wednesday, according to Rick Stroud of the Tampa Bay Times. Stroud reports that Irving is "still in the rehab phase." The 23-year-old has not played since Week 4 as he battles foot and shoulder injuries. There had been hope that Irving would be ready to return for Tampa Bay's Week 10 matchup against the New England Patriots coming off the team's Week 9 bye. However, it appears that Irving's status for the game is still very much up in the air. If Irving misses a fifth consecutive game in Week 10, Buccaneers running backs Rachaad White and Sean Tucker would likely split backfield reps against New England. In Tampa Bay's Week 8 win over the New Orleans Saints, White saw 15 total touches compared to 12 for Tucker.

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Cleveland Browns rookie running back Quinshon Judkins (shoulder) is expected to return to practice on Wednesday ahead of Week 10. Judkins suffered an AC joint sprain in Week 8, but the Week 9 bye provided valuable recovery time. Through seven games, the rookie has handled 118 carries for 486 yards and five rushing touchdowns, while adding 12 receptions for 60 yards, solidifying his role as the lead back in Cleveland's offense. The Browns draw a favorable Week 10 matchup against the New York Jets, who have allowed the 11th-most fantasy points to opposing running backs this year. Judkins is on track to play and should be viewed as a strong RB2 with touchdown upside in this matchup.

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New York Jets running back Isaiah Davis was one of the bigger losers of the trade deadline. After weeks of speculation that the team might move Breece Hall, the Jets ultimately held onto their starter, keeping him locked in as the clear RB1. Davis was coming off the best performance of his young career before the bye, totaling 109 scrimmage yards on 12 touches, showing burst and efficiency when given opportunities. However, his path to meaningful volume remains limited with Hall still leading the backfield. The Jets also face a difficult Week 10 matchup against Cleveland, a defense allowing the second-fewest fantasy points to running backs. Davis currently profiles as a stash-and-hold handcuff rather than a startable option.

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Seattle Seahawks wide receiver Tory Horton has been a touchdown machine in his rookie season, scoring five touchdowns on just 13 receptions. He posted a career day in Week 9 with four catches for 48 yards and two scores while logging a season-high 73% snap share. However, Seattle's trade for Rashid Shaheed may limit Horton's fantasy trajectory. Shaheed recorded 44 receptions in nine games with the Saints this season and is expected to slide in as the No. 2 option alongside Jaxon Smith-Njigba. With Shaheed likely to command consistent snaps and targets, Horton becomes a far more volatile play. He should be viewed as a stash-only option in deeper leagues, not a weekly fantasy starter.

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Chicago Bears wide receiver Olamide Zaccheaus is coming off his best performance of the season, posting six receptions for 58 yards and a touchdown in Week 10 against Cincinnati. With rookie Luther Burden III (concussion) sidelined, Zaccheaus logged his second-highest snap share of the year (66%) and delivered as the primary slot option in Ben Johnson's scheme. He's developed solid chemistry with Caleb Williams, and now draws a favorable Week 11 matchup against the Giants, who allow the fourth-most fantasy points to opposing wideouts. If Burden remains out, Zaccheaus carries deep-league FLEX value against a struggling Giants secondary.

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Dynasty | The Saints did not trade wide receiver Chris Olave prior to Tuesday's deadline. Dynasty Analysis: Olave was rumored to be of interest to several teams, including the Bills (let your imagination wander). However, the Saints kept him in the hopes they could sign him to an extension. We'll see if that pans out in the end, but anyone with Olave on their dynasty roster has to be at least a little disappointed. Let's face it - Olave has a high floor and a low ceiling in an offense led by Tyler Shough or Spencer Rattler.

Chicago Bears rookie tight end Colston Loveland broke out in a big way in Week 9, catching six of seven targets for 118 yards and two touchdowns in the Bears' 47-42 win over the Bengals. The highlight came on a 58-yard game-winning touchdown, capping off a monster performance that pushed Chicago to a 5-3 record. With Cole Kmet exiting early due to a concussion, Loveland stepped in as the primary tight end, logging 79% of the offensive snaps. Now, with Kmet still in concussion protocol entering Week 10, Loveland could once again handle a full workload against the New York Giants, who have allowed the ninth-most passing yards in the NFL this season. If Kmet remains sidelined, Loveland is a must-start fantasy option across all formats, offering TE1 upside in Week 10.

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With Jayden Daniels (elbow) expected to miss time following a gruesome Week 9 injury, Marcus Mariota is set to take over as the Washington Commanders' starting quarterback for the foreseeable future. In three starts this season, the veteran has completed 52 of 78 passes (66.7%) for 576 yards, throwing four touchdowns and three interceptions, while adding 102 rushing yards and a touchdown on 16 carries. Mariota draws a favorable Week 10 matchup against the Detroit Lions, who have allowed the 10th-most fantasy points per game to quarterbacks this season. With his dual-threat ability and favorable matchup, Mariota profiles as a low-end QB2 for Week 10, and potentially beyond if Daniels remains sidelined.

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New York Giants wide receiver Darius Slayton emerged as one of the quiet winners of the NFL Trade Deadline. While several teams reshaped their receiving corps during the deadline, the Giants stood pat, signaling confidence in their current group and keeping Slayton locked in as a top option. Through seven games, Slayton has caught 19 of 30 targets for 254 yards without finding the end zone. Despite modest production, he's played on 85% of the team's offensive snaps, maintaining a strong role in the offense. With rookie quarterback Jaxson Dart continuing to impress, Slayton's breakout could be right around the corner. In Week 10, Slayton draws a favorable matchup against the Chicago Bears, who have allowed the fifth-most fantasy points per game to wide receivers. Given his snap share and matchup, Slayton profiles as an intriguing deep-league FLEX flier this week.

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Green Bay Packers tight end Luke Musgrave is set to step up as the team's new TE1 with the unfortunate injury to Tucker Kraft (knee) in Week 9. Kraft is out for the season, and Musgrave becomes the next man up. Musgrave is also not a nobody; he was actually drafted ahead of Kraft in the 2023 NFL draft. Musgrave was the starter for most of his rookie season until an injury opened the door for Kraft. For a team looking for a replacement at the tight end spot after Kraft's injury, Musgrave is a likely candidate and worth the pick-up. However, fantasy managers should temper their expectations, as Jayden Reed (collarbone, foot) is set to return soon, and the Packers' pass-catchers still include Christian Watson, Romeo Doubs, Matthew Golden, and now Musgrave. The point being, there are a lot of mouths to feed, and what made Kraft so special was his ability to create yards after catch (15.3 yards per reception). Moving forward, fantasy managers should view Musgrave as a touchdown-dependent TE2.

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The Las Vegas Raiders traded away Jakobi Meyers on Tuesday, and now Tucker is listed as the team's No. 1 wide receiver. Obviously, Brock Bowers is the number one pass-catching option for the Raiders offense, but Meyers was averaging seven targets per game. Those targets now have to go to somebody else, with Tucker and Bowers being the most likely candidates. Tucker has had some spike weeks in 2025, with a three-touchdown game back in Week 3, but has been more of a boom-or-bust WR3 option for fantasy managers with 427 receiving yards and four touchdowns through nine weeks. With Meyers on the move and a clear path for more targets, Tucker could work his way into the low-end WR2 conversation moving forward, but certainly has to prove it first. Tyler Lockett, Dont'e Thornton, and Jack Bech are not much of a threat for targets at this time.

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Jacksonville Jaguars wide receiver Parker Washington led the Jaguars in targets and receptions in Week 9 against the Las Vegas Raiders. He hauled in eight of his nine receptions for 90 yards, with a very solid 26 percent target share. Travis Hunter (knee) is out for another three games minimum, Brenton Strange (hip, quadriceps) is sidelined, and Brian Thomas Jr. (ankle) is struggling in 2025 and rolled his ankle late in the game on Sunday, and is questionable heading into Week 10. The Jaguars traded for Jakobi Meyers on Tuesday; however, Washington should still receive a majority of the looks on Sunday against the Houston Texans while Meyers adjusts to the new offense. The unfortunate news is that the Texans are a tough matchup, allowing the fourth fewest points to opposing wide receivers. Derek Stingley Jr. is also one of the top cornerbacks in the game, so it might be tough sledding for the Jaguar pass catcher he guards on Sunday. That said, the targets should be there for Washington, as he's now seen 19 over his last two games, making him a flex option in Week 10 and a must-add off the waiver wire.

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New York Giants running back Devin Singletary was expected to have an increased role this weekend with Cam Skattebo (ankle) sidelined for the rest of the season. However, nobody expected him to out-touch Week 9's hottest waiver wire pickup, Tyrone Tracy Jr. Singletary not only out-touched Tracy 10 to nine, but he also played 56% of the snaps compared to Tracy's 44%. Singletary was also more efficient with his touches, averaging 5.38 YPC to Tracy's 3.60 YPC. It's a small sample size of one game, so it's important not to overreact, considering Tracy was the starter in 2024; however, it's a situation to monitor moving forward, and Singletary no longer deserves to be on the waiver wire in 12-team formats. He should be rostered heading into Week 10 and has some RB3 value against the Chicago Bears, who rank middle of the pack against opposing running backs.

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