Kansas City Chiefs wide receiver Xavier Worthy (ankle, shoulder) was back on the practice field on Friday after missing the team's Thursday practice, according to Taylor Burr of Fox4 Sports. Additionally, Sam McDowell of The Kansas City Star reports that Chiefs head coach Andy Reid said he anticipates Worthy being available in Week 6 against the Detroit Lions. Worthy dislocated his shoulder on Kansas City's opening drive in Week 1 and missed Weeks 2 and 3 as a result. In the two full games he's played this season, the 22-year-old has recorded 11 catches for 125 yards on 17 targets. With top Chiefs wideout Rashee Rice sidelined for Week 6 due to suspension, Worthy should be expected to take on a WR1 workload once again against the Lions. Worthy profiles as a must-start fantasy wide receiver in Week 6.

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New Orleans Saints running back Alvin Kamara (ankle) is questionable to play in the team's Week 6 game against the New England Patriots, according to Rod Walker of The New Orleans Advocate. Kamara has been listed as a limited practice participant this week after suffering an ankle injury during practice on Wednesday. The 30-year-old has recorded 360 scrimmage yards and one touchdown on 90 total touches. If he were unable to play in Week 6, Saints running back Kendre Miller would be in line for a significant workload increase. Assuming Kamara can suit up, he profiles as a high-end RB3/flex option in Week 6 against New England.

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With kicker Joey Slye (calf) officially out for Week 6 due to a calf injury, the Tennessee Titans will turn to Matthew Wright to handle the kicking duties on Sunday against the Las Vegas Raiders. Wright has appeared in 29 games across five NFL seasons for six different teams, making 55 out of 63 (87.3%) of his career field goal attempts. Wright appeared in five games spread across three teams in 2024, including two with Tennessee. He made 15 out of 16 field goal attempts last year, although his longest make was from just 50 yards out. Wright profiles as a kicker for fantasy managers to avoid in Week 6 against the Las Vegas Raiders.

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Tampa Bay Buccaneers head coach Todd Bowles replied, "I hope so," when asked whether wide receiver Jalen McMillan (neck) will play in 2025, per Greg Auman of Fox Sports. Bowles did note that McMillan is "getting better" but is "still in the neck brace." The second-year wide receiver suffered a neck injury during the preseason and is currently on Injured Reserve. McMillan recorded 37 catches for 461 yards and eight touchdowns on 58 targets in 13 games last season, but it does not appear he is close to making his 2025 debut. The Buccaneers' wide receiver corps is currently quite depleted, with wideouts Mike Evans (hamstring) and Chris Godwin (fibula) both set to miss the team's Week 6 matchup against the San Francisco 49ers. Evans and Godwin are both expected to return before McMillan, but Buccaneers rookie wide receiver Emeka Egbuka could have an extended run as the team's WR1.

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Tennessee Titans kicker Joey Slye (calf) has officially been ruled out for the team's Week 6 matchup against the Las Vegas Raiders due to a calf injury, per Jim Wyatt of TennesseeTitans.com. Slye leads the league in both field goal attempts (17) and makes (13 through five weeks so far this season. With Slye sidelined, Tennessee will reportedly let veteran Matthew Wright handle the kicking duties in Week 6. Wright has appeared in 29 games across five NFL seasons for six different teams. He's made 55 out of 63 (87.3%) of his career field goal attempts. Wright should be avoided by fantasy managers in Week 6 against Las Vegas.

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Dynasty | Giants running back Cam Skattebo had 98 rushing yards, two catches, 12 receiving yards, and three touchdowns in a win against the Eagles. Dynasty Analysis: This performance officially anoints Skattebo as the unquestioned three-down option in New York and puts him squarely on the map as an RB1/2 moving forward. Skattebo has quickly risen up the depth chart in New York and his bruising, physical running style seems to fit the team perfectly. At this point, he's going to be tough to keep out of dynasty lineups, regardless of touchdowns being tough to predict. His ADP and rookie ranking continue to rise.

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Dynasty | Giants quarterback Jaxson Dart completed 17-of-25 passes for 195 yards with one touchdown and no interceptions, while rushing for 58 yards and adding another score in an upset win over the Eagles. Dynasty Analysis: Dart is now the toast of the town for the Giants as he's clearly given them a spark on offense. While the passing yardage totals aren't blowing anyone away, his rushing totals are making a difference and he isn't turning the ball over. One can only wonder what this would look like with a healthy Malik Nabers, but that's for another day. At this point, Dart is moving up the rankings board as a young quarterback who could have the "it" factor.

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Dynasty | Giants quarterback Russell Wilson threw one incomplete pass before moving back to the bench after covering for a temporary unavailable Jaxson Dart for one play. Dynasty Analysis: He was subsequently booed off the field. It's safe to say the city has turned on Russell and it was actually quite sad to see this play out. The Giants may face a fine for rushing Dart back on the field after going through a pretty quick concussion protocol test. Regardless, they couldn't get Wilson off the field fast enough. It wouldn't be surprising to see Wilson request a trade or even be released knowing the Giants still have Jameis Winston on the bench. His dynasty value is now non-existent.

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Dynasty | Eagles tight end Dallas Goedert had nine catches for 110 yards and a touchdown in a loss to the Giants. Dynasty Analysis: Goedert has now scored in four straight games, despite the Eagles having all kinds of trouble on offense. While he likely can't keep up a pace like this, Goedert has established himself as a weekly TE1 and has to be in lineups moving forward. He also could be a quick trade chip if he's on a dynasty team failing to win games at the moment. His value may be at its apex right now.

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Dynasty | Eagles running back Saquon Barkley had 58 rushing yards, two catches and nine receiving yards in a loss to the Giants. Dynasty Analysis: So much for #revenge game. Barkley had 31 yards on his first two carries but the Eagles then attempted to do everything else in the offense other than giving him the ball. The offensive coordinator change, offensive line play, general play calling, and Barkley himself getting older may all be contributing factors but the fact is he's in a major slump. At this point, he has to be considered a RB2 until we see some signs of life.

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When asked if Indianapolis Colts wide receiver Adonai Mitchell would be active for the Week 6 contest against the visiting Arizona Cardinals on Sunday, head coach Shane Steichen said, "We're working through that," according to Jake Arthur of Locked On Colts. Mitchell is currently in the dog house in Indy after making two crucial mistakes in the team's Week 4 loss to the Los Angeles Rams. Alec Pierce (concussion) missed a second straight game in last week's blowout win over the Las Vegas Raiders, but Mitchell took on a much smaller role, playing just six offensive snaps and being targeted just once. Ashton Dulin was the beneficiary of the offense with Mitchell essentially benched, and he caught two passes for 55 yards. Pierce has cleared the league's concussion protocol and will play against Arizona, so there's a chance Mitchell will be a healthy scratch. Regardless, Mitchell's arrow is pointed firmly downward right now.

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Indianapolis Colts head coach Shane Steichen said that wide receiver Alec Pierce (concussion) will play in Week 6 on Sunday against the visiting Arizona Cardinals after clearing the league's concussion protocol this week, according to Stephen Holder of ESPN. Pierce missed the team's last two games as a result of his head injury that he suffered in Week 3. The 25-year-old looked like he was close to playing in Week 5, but he was eventually ruled out after suffering a setback last Friday. With Pierce back in the fold, Adonai Mitchell could be on his way to being a healthy scratch after seeing his role dramatically reduced last Sunday following two crucial mistakes in the Week 4 loss. Pierce should settle back in as a top-three wideout for the Colts alongside Michael Pittman Jr. and Josh Downs. Before his injury, the former second-rounder had caught nine passes for 171 yards and no touchdowns in three games.

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Cleveland Browns rookie fifth-round quarterback Shedeur Sanders will serve as the backup to fellow rookie Dillon Gabriel in the Week 6 divisional clash on Sunday against the Pittsburgh Steelers, according to head coach Kevin Stefanski. Sanders began the year buried on Cleveland's QB depth chart, but he has slowly risen up the ranks after the Browns traded both Joe Flacco and Kenny Pickett. The 23-year-old showed well in training camp and the preseason and has been praised by the coaching staff for the work that he's put in, but they are going to continue to develop him at their own pace in what is looking like another rebuilding year. Gabriel will probably have a long leash under center as he heads into just his second NFL start this weekend against Pittsburgh. However, Sanders' odds of seeing action in 2025 later this year have risen dramatically after the trade of Flacco this week. He is still only deserving of being rostered in fantasy in dynasty/keeper leagues.

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Cincinnati Bengals wide receiver Ja'Marr Chase (illness) has popped up on the Week 6 injury report and will be questionable for Sunday's game against the Green Bay Packers, according to head coach Zac Taylor. Chase was under the weather and was unable to practice on Friday, per Ben Baby of ESPN. The 25-year-old's status is now worth monitoring going into Sunday's game at Lambeau Field, but in all likelihood, he will be ready to play come Sunday. As long as Chase is active, he proved last week that he remains a must-start in fantasy, even without quarterback Joe Burrow (toe). The Bengals will be debuting new QB Joe Flacco in Week 6 against the Packers. Flacco may not necessarily be an upgrade over Jake Browning under center, but he shouldn't be shy about forcing targets to Chase and Tee Higgins, the Bengals' best two pass-catchers. Chase is coming off a six-catch, 110-yard, two-touchdown performance in the Week 5 loss to the Detroit Lions.

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Jacksonville Jaguars tight end Brenton Strange (hip, quadriceps), who leads the team in catches through five weeks, is dealing with a hip and quad injury that includes a ligament tear, sources tell Jordan Schultz of FOX Sports. Strange suffered the injury in the Monday night win over the Kansas City Chiefs. Schultz said it's his understanding that Strange doesn't need surgery, but he will be out at least five weeks. It could have been worse, but Jacksonville is going to be without its top TE for a while. The 24-year-old was placed on Injured Reserve earlier this week, which means he'll be out at least four games. Strange was having a nice start to the year before his injury, catching 20 passes for 204 yards, although he hadn't found the end zone. In his absence, the Jags will look to both Hunter Long and Johnny Mundt for production at the TE position. Fantasy managers should be able to find better TE2 streamers elsewhere.

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The Carolina Panthers have listed tight end Ja'Tavion Sanders (ankle) as questionable to play in the Week 6 tilt against the visiting Dallas Cowboys on Sunday, according to The Athletic's Joe Person. Sanders was limited in Wednesday's practice, was able to practice in full on Thursday, and was then limited again on Friday. The 22-year-old is attempting to return from a high-ankle sprain that has kept him sidelined for the last two weeks. Sanders will test out his ankle during pre-game warmups on Sunday and is being treated as a game-time decision this weekend. Carolina could get both Sanders and receiver Jalen Coker (quadriceps) back, but the offense will be without running back Chuba Hubbard (calf) for a second straight week. Tommy Tremble has seen more pass-game looks at tight end with Sanders out the last couple of weeks, but if Sanders returns on Sunday, he should step right back into his TE1 in Carolina.

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The Carolina Panthers have ruled out running back Chuba Hubbard (calf) for their Week 6 contest this Sunday against the visiting Dallas Cowboys, according to Joe Person of The Athletic. It will be the second straight game that Hubbard is inactive due to a calf injury that he suffered in Week 4. Rico Dowdle burst onto the scene as Hubbard's replacement in the Week 5 win over the Miami Dolphins and was dominant with the ball in his hands, rushing for over 200 yards on the ground and a touchdown. Fantasy managers shouldn't be expecting a repeat, but the increased volume as the clear-cut RB1 in the backfield for a second straight week pretty much makes Dowdle a must-start RB2 in fantasy lineups for the second straight week in a revenge game against his former team. Hubbard's next chance to return to action will be in Week 7 against the New York Jets.

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The Carolina Panthers have listed wide receiver Jalen Coker (quadriceps) as questionable to make his 2025 debut in Week 6 against the visiting Dallas Cowboys on Sunday, according to Joe Person of The Athletic. Despite practicing in full on Wednesday and Thursday, Coker will be a game-time decision on Sunday. The 23-year-old missed the first five weeks of the season due to a pretty serious quadriceps injury that he suffered at the end of August, but he's almost fully recovered. The Panthers could ease Coker back into the fold whenever he's officially activated from Injured Reserve, but given the lack of production behind rookie Tetairoa McMillan this year, the second-year pass-catcher could quickly earn plenty of playing time in Carolina. Coker won't be a realistic starting option in fantasy if he's active this weekend, but he's deserving of a waiver-wire pickup and stash now that his 2025 debut is just around the corner.

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The Tampa Bay Buccaneers will be without wide receiver Mike Evans (hamstring) for a third straight game when they take on the San Francisco 49ers on Sunday in Week 6, according to Rick Stroud of the Tampa Bay Times. In addition to Evans being out, Tampa will also be without veteran pass-catcher Chris Godwin (leg). Evans will miss a third straight contest after straining his left hamstring in the Week 3 win over the New York Jets. The 32-year-old future Hall of Famer will need to return to practice next week if he is to have any chance at returning for a Monday night showdown against the Detroit Lions to close out Week 7 action. With both Evans and Godwin out this weekend, rookie first-rounder Emeka Egbuka, Sterling Shepard, and Tez Johnson should start in three-wide sets. Tight end Cade Otton will also have a higher ceiling. Shepard is worth looking at as a flex play in deeper leagues with more targets coming his way.

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Green Bay Packers wide receiver Christian Watson (knee) will not play in Week 6 against the Cincinnati Bengals, but head coach Matt LaFleur said he's looked "pretty damn good" and that he's "excited for when that day comes," according to Rob Demovsky of ESPN. The Packers aren't going to rush Watson back after he tore his ACL in the Week 18 regular-season finale last year. The 26-year-old returned to practice for the first time this year on Wednesday and has been limited this week. Depending on how much Watson is able to do next week in practice, it's possible he'll officially be activated from the Physically Unable to Perform list to make his debut in Week 7 versus the Arizona Cardinals. Watson has had trouble staying healthy early in his NFL career and will be returning to a crowded receiving corps, but he has the potential to be an explosive deep threat for the Packers' offense when everything is right.

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