Kansas City Chiefs running back Kareem Hunt will face the Indianapolis Colts in Week 12. Hunt handled 13 carries for 59 yards and a touchdown, along with one catch for three yards. His 59 rushing yards were a season-high, and his 13 carries tied his season-high. With Isiah Pacheco out in Week 11, Hunt was the only back to get any rushing work. Rookie Brashard Smith was relatively uninvolved in the contest, only catching two passes for eight yards. With Pacheco ruled out again for Week 12, Hunt should dominate touches against Indianapolis. The Colts defense has been an average matchup for fantasy running backs this season, but the scoring potential makes Hunt an interesting play. The Colts offense is the highest-scoring in the league, and this game has a nearly 50-point projected total, meaning that Hunt could visit the end zone once or twice. Hunt should be viewed as a viable RB2 with upside in Week 12.

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San Francisco 49ers veteran wide receiver Kendrick Bourne enjoyed a mid-season spike that saw him put up exactly 142 receiving yards in back-to-back games in Weeks 5 and 6. Since then, the 49ers' offense has gotten healthier, and Bourne is no longer a viable fantasy option. In Weeks 7 through 10, Bourne was still listed as a starter, but with All-Pro tight end George Kittle playing in all those games following a five-week absence, Bourne averaged only two receptions for 28 yards. In Week 11, Ricky Pearsall returned after a six-week absence of his own, and Bourne was limited to 13 offensive snaps and kept off the stat sheet. While his chemistry with Mac Jones made him a surprising fantasy producer just as bye weeks struck, it is apparent that Bourne is no longer a reliable piece of San Francisco's offense and can be dropped by any fantasy managers who have not yet done so.

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Kansas City Chiefs running back Brashard Smith will face the Indianapolis Colts in Week 12. Smith had zero carries and two catches for eight yards in last week's loss to the Denver Broncos. Even with Isiah Pacheco missing the game, Smith did not have a single opportunity in the run game. The same should be expected this week with Pacheco ruled out again for the Colts matchup. Veteran back Kareem Hunt is the most trusted back on the roster and should be leaned on in a crucial AFC matchup. The Chiefs are currently sitting at 5-5 and third in their division, so they need to start stacking wins if they want to make the playoffs. Given the lack of involvement on the ground and sparse usage through the air, Smith should not be trusted in fantasy lineups this week.

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Cleveland Browns wide receiver Jerry Jeudy had his best game of the season in the Week 11 loss to the New York Jets, catching six of his 12 targets for 78 yards and his first touchdown of the season. Fantasy managers who had picked Jeudy up off the waiver wire were hoping he'd continue that momentum into Week 12 versus the Baltimore Ravens, but it didn't happen. The 26-year-old caught three of seven targets for just 21 yards in the loss. The good news is that he led the team with seven targets, but the bad news is that rookie quarterback Dillon Gabriel left the game with a concussion and did not return. Gabriel will not play this Sunday against the Las Vegas Raiders, leaving fellow rookie Shedeur Sanders to make his first NFL start. Sanders completed just 25% of his passes in relief of Gabriel last Sunday and is a serious dice roll this weekend. It will be very difficult to trust Jeudy in a starting lineup spot in fantasy in Week 12.

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Tennessee Titans rookie wide receiver Elic Ayomanor (hamstring) has been ruled out of Sunday's Week 12 matchup with the Seahawks. In a season that has produced little offensive firepower, Ayomanor leads the Titans in targets (59), receiving yards (334), and receiving touchdowns (2). His 28 receptions through ten games trail only tight end Chig Okonkwo (32). With veteran Calvin Ridley (leg) placed on season-ending Injured Reserve on Tuesday, Okonkwo and fellow rookie Chimere Dike figure to be the focal points of the Titans' passing offense. While the Seahawks' defense has been smothering for most of the year, the one spot they have shown susceptibility to is the tight end position, making Okonkwo the only Titan worthy of fantasy consideration this week.

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Kansas City Chiefs running back Isiah Pacheco (knee) has been ruled out of Sunday's matchup with the Colts, making this his third straight missed game after spraining his MCL in a Week 8 win over the Commanders. Pacheco had been listed as a full participant in Wednesday's practice, giving fantasy managers hope that he could return this week. He unfortunately followed that up with limited participation on Thursday and has been ruled out on Friday. In his absence, veteran running back Kareem Hunt has averaged 12 carries for 54 yards, while scoring a touchdown in both games to bring his streak up to three straight. The 8-2 Colts have been below-average against fantasy running backs, keeping Hunt in play as a TD-dependent flex option. Rookie Brashard Smith will remain limited in the RB2 role behind Hunt.

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Atlanta Falcons wide receiver Drake London (knee) has been ruled out of Sunday's divisional matchup with the Saints. London left the team's Week 11 loss to the Panthers with what was later revealed to be a PCL sprain. With second-year quarterback Michael Penix Jr. (knee) placed on Injured Reserve earlier this week, the Falcons travel to New Orleans short-handed on offense. Wide receiver Darnell Mooney and tight end Kyle Pitts Sr. will presumably be tasked with absorbing some of London's 9.6 targets per game. While Mooney has topped 35 yards only once since returning from a hamstring injury in Week 7, he has displayed chemistry with quarterback Kirk Cousins in the past, topping 100 yards twice in 2024 and recording all of his career-high five receiving touchdowns with Cousins under center. Given the nature of his injury, fantasy managers shouldn't be surprised if London misses multiple games.

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Kansas City Chiefs quarterback Patrick Mahomes will face the Indianapolis Colts in Week 12. Mahomes completed 29 of 45 pass attempts (64%) for 276 yards and a touchdown in the team's loss to the Broncos in Week 11. The veteran QB struggled against the stout Denver defense, taking three sacks and throwing an interception last week. Mahomes and the Chiefs have now lost back-to-back games for the second time this season and will look to bounce back against Indianapolis. The Colts defense has been an average matchup for opposing quarterbacks, but their offense is the main reason to be intrigued. The Indianapolis offense is the highest scoring offense in the league, with the most yards and points scored this season. This Chiefs-Colts matchup is tied for the third-highest total of the week, meaning Vegas is predicting a shootout. Mahomes should be able to keep pace with the Colts, leading to a potential ceiling performance. Mahomes is ranked QB4 in our RotoBaller rankings, making him a must-start QB1 once again.

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New England wide receiver Kayshon Boutte (hamstring) has responded well to a week of practice, and he is expected to return to action when the Patriots face the Bengals in Week 12. Boutte missed the last two games after exiting the Patriots' Week 9 win over the Falcons with a hamstring injury. In his absence, veteran receiver Mack Hollins has stepped in as the team's most prolific deep threat, catching 10 of his 15 targets for 170 yards in wins over the Buccaneers and Jets. With Boutte back in action, the expectation is that Hollins will return to a role closer to the line of scrimmage and Boutte will continue to see work downfield. Boutte's 17.7-yard average depth of target ranks fifth among qualified wide receivers, and he is one of only three receivers with an ADoT above 13 yards and a reception percentage above 70%, illustrating his chemistry with Drake Maye and value within this offense. Against a subpar Bengals defense, he should be right back in play as a high upside flex play.

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Pittsburgh Steelers head coach Mike Tomlin told reporters that quarterback Aaron Rodgers (wrist) is questionable for Sunday's game in Chicago against the Bears in Week 12 after being limited in Friday's practice, per Ian Rapoport of NFL Network. "We'll see where the weekend leads us," Tomlin said. Rodgers suffered a small fracture in his left (non-throwing) wrist in Sunday's win over the Cincinnati Bengals and is now up in the air to start this weekend. The 41-year-old said it's "a safety thing" rather than a pain-management issue as to whether he actually suits up. The good news for fantasy managers deciding whether to use the future Hall of Famer as a QB2 this weekend is the fact that Pittsburgh and Chicago kick off in the early window on Sunday. If Rodgers is inactive in Chicago, Mason Rudolph will make his first start in 2025.

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Kansas City Chiefs running back Isiah Pacheco (knee) is practicing again on Friday, according to The Kansas City Star's Pete Sweeney. Pacheco, who has missed the team's last two games due to a right-knee injury, was a full practice participant on Wednesday before being downgraded to limited on Thursday. The 26-year-old has been wearing a bulky brace on his knee this week. Pacheco being back at practice on Friday suggests that his downgrade to limited on Thursday was more maintenance-related than an actual setback. KC's backfield will become even messier if Pacheco returns this weekend against the Colts, although veteran Kareem Hunt will likely maintain his role as the Chiefs' preferred goal-line option. Between sharing touches with Hunt and rookie Brashard Smith and not seeing goal-line looks, Pacheco has become a low-upside RB3/flex for fantasy managers. He comes into Week 12 with 329 rushing yards and only one touchdown on 79 rushing attempts.

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New England Patriots running back Rhamondre Stevenson (toe) is expected to be cleared to make his return for this Sunday's game against the Cincinnati Bengals in Week 12, according to Chad Graff of The Athletic. Despite only being limited in practice this week, Stevenson appears ready to return for the first time since picking up a toe injury in the Week 8 win over the Cleveland Browns. The 27-year-old was operating as the Patriots' RB1 before his injury and had 83 rushing attempts for 279 yards (3.4 yards per carry) and three touchdowns in eight games. Rookie TreVeyon Henderson saw 47 rushing attempts for 264 yards and four touchdowns in the three games that Stevenson missed, adding 10 catches for 66 yards and another TD. Henderson's breakout likely earned him a larger role when Stevenson returns, so fantasy managers will want to temper expectations if Stevenson is active in Cincy.

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Kansas City Chiefs wide receiver Xavier Worthy (ankle) is on the practice field on Friday, according to Pete Sweeney of The Kansas City Star. Worthy did not practice on Wednesday due to an ankle injury, but he returned to a limited practice on Thursday. The 22-year-old might need a full practice on Friday to avoid a questionable tag going into the weekend, but either way, the second-year speedster appears to be on the right side of questionable to play this Sunday versus the visiting Indianapolis Colts. Worthy has not missed any time this year due to his ankle injury, but he did miss Weeks 2 and 3 due to a dislocated shoulder. He currently has 27 catches for 281 yards and only one touchdown on 45 targets in 2025, and he has become a less reliable fantasy wideout since the return of Rashee Rice.

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Cleveland Browns tight end David Njoku (knee) returned to practice on Friday, according to Daniel Oyefusi of ESPN. It's unclear what Njoku's participation level was, but it at least gives him a chance to play in Week 12 against the Las Vegas Raiders after he missed practice on Wednesday and Thursday. The 29-year-old could very well be listed as questionable on the final injury report, though, and his status remains up in the air for the weekend. Njoku has already seen a drop in fantasy value this season with rookie Harold Fannin Jr. stealing lots of valuable targets from him, so he's even harder to trust going into Sunday's game, given his uncertain status. Through 11 weeks in the 2025 season, Njoku has 30 receptions for 288 yards and three touchdowns on his 45 targets. All of Cleveland's pass-catchers will be a bit more volatile in Week 12 with rookie quarterback Shedeur Sanders making his first career start.

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The Green Bay Packers opened the 21-day practice window on wide receiver Jayden Reed (collarbone, foot) on Friday, according to Bill Huber of SI.com. Reed is practicing for the first time since breaking his collarbone in Week 2. The 25-year-old also had surgery to fix a Jones fracture in his foot. He is making progress and nearing a return, but he won't play this Sunday against the division-rival Minnesota Vikings and is unlikely to be back for the Thanksgiving Day game next Thursday against the division-rival Detroit Lions. That means the most realistic date for Reed to return would be on Sunday, Dec. 7, when the team takes on the division-rival Chicago Bears in Week 14. Reed has demonstrated a nose for the end zone early in his career, scoring 18 times in 35 regular-season games, but he'll probably be a volatile commodity in the fantasy playoffs in a crowded WR room in Green Bay when he finally returns.

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The Cincinnati Bengals have not made a final decision on whether quarterback Joe Burrow (toe) will play on Sunday against the New England Patriots, according to head coach Zac Taylor. Burrow was limited in practice on Friday and will officially be listed as questionable for Week 12. Both Burrow and Joe Flacco (shoulder) got reps in practice on Friday. "He's done everything he can," Taylor said about Burrow. The 28-year-old Burrow is still on Injured Reserve, so we should have an answer by Saturday as to whether the Bengals plan to start him this weekend. Flacco continues to deal with an AC joint sprain in his right shoulder, but if Cincy decides to hold Burrow out for another week, Flacco should be available to make one more start this weekend. There's no question that Burrow gives the Bengals offense more upside, but there could be a rust factor since he has not played since Week 2, and Cincy will also be without top wideout Ja'Marr Higgins (suspension) against New England.

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Tampa Bay Buccaneers head coach Todd Bowles said that wide receiver Chris Godwin (leg) is trending toward playing on Sunday night against the Los Angeles Rams in Week 12, according to Greg Auman of FOX Sports. Godwin has not played since injuring his fibula in Week 5, but he was able to practice in full on Thursday and appears ready to return this weekend. The 29-year-old has only played in two games in 2025 after suffering a serious ankle dislocation in Week 7 of the 2024 season. The Bucs have already said that Godwin will have his snaps limited in his first game back after the long layoff, so we wouldn't recommend starting him in fantasy if he's active on Sunday night in a tough matchup on the road. Still, fantasy managers should have Godwin rostered in most leagues for the stretch run, as he figures to be a key target for quarterback Baker Mayfield with Mike Evans (collarbone) likely done for the year.

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Tampa Bay Buccaneers head coach Todd Bowles said that running back Bucky Irving (foot, shoulder) has been ruled out for the Week 12 game this Sunday night against the Los Angeles Rams, according to Scott Smith of Buccaneers.com. Fantasy managers will be disappointed that Irving won't be back this weekend after it seemed he had been trending towards returning for the first time since Week 4, but the good news is that the Bucs are targeting a return for Irving in Week 13 against the Arizona Cardinals. A report from Pewter Report suggested that Irving was "reeling a bit" after being injured for the first time in his career and missing football, but he's "feeling better and is on the road to recovery." It's anyone's guess as to how Tampa's backfield will look when Irving finally returns, but for this Sunday against the Rams, Sean Tucker figures to see more work over Rachaad White after his three-touchdown performance in last week's loss to the Buffalo Bills.

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Baltimore Ravens wide receiver Rashod Bateman (ankle) was absent from practice on Friday for the third time this week, according to ESPN's Jamison Hensley. Bateman suffered a high-ankle sprain in the Week 10 win over the Minnesota Vikings and did not play in last week's win over the Cleveland Browns. Without being able to practice this week, the 25-year-old will most likely be ruled out for a second straight game this weekend. Bateman's absence will once again open up more targets in the passing game against the New York Jets this Sunday for receivers Zay Flowers, DeAndre Hopkins, and Tylan Wallace. Tight ends Mark Andrews and Isaiah Likely should also have slightly higher ceilings. Bateman had the best year of his career in 2024 with 756 receiving yards and nine touchdowns, but he's been a disappointment once again for fantasy managers in 2025 with a 16-194-2 line in nine games.

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Baltimore Ravens quarterback Lamar Jackson (ankle) is practicing for the second straight day on Friday, according to Jamison Hensley of ESPN. Jackson was held out of practice on Wednesday with an ankle injury, but he was a full participant on Thursday and appears to be just fine for the Week 12 matchup this Sunday against the visiting New York Jets. The 28-year-old two-time MVP missed several games earlier this season due to a hamstring injury, but even before the injury, he wasn't running all that much. Jackson has only scored on the ground once so far in seven games in 2025, and that was back in Week 1. He threw four touchdowns in his return from his hamstring injury against Miami on Oct. 30, but in the last two games, he has one touchdown and two picks. Jackson should still be considered a high-end QB1 option in a prime bounce-back matchup against the Jets.

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