San Francisco 49ers tight end George Kittle (hamstring) has been ruled out for the remainder of Sunday's Week 1 contest against the Seattle Seahawks. At the time of his departure, he had caught four passes for 25 yards and one touchdown. The star tight end is one of the focal points of San Francisco's offense, and he has been able to stay relatively healthy, missing just two games in 2024. His injury represents a major concern for the Niners in Week 1 and beyond. Fantasy managers should monitor Kittle's practice status next week, as it's too early to tell whether this might be a multi-week absence. Luke Farrell will operate as the 49ers' primary tight end until Kittle can return.

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Los Angeles Rams tight end Colby Parkinson (shoulder) exited during the first half of Sunday's Week 1 contest against the Houston Texans. He is questionable to return. At the time of his departure, he had been targeted just once, resulting in a one-yard reception. Parkinson's injury comes at a time when the Rams couldn't afford to lose another pass-catcher. Moments earlier, Puka Nacua (head) exited to be evaluated for a concussion. Davante Adams remains Matthew Stafford's top target with Nacua and Parkinson sidelined, while players like Tyler Higbee and Tutu Atwell should also see additional opportunities in the passing game.

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Los Angeles Rams wide receiver Puka Nacua (head) was taken to the locker room to be evaluated for a concussion during the first quarter of Sunday's Week 1 contest against the Houston Texans. He is questionable to return. The injury appeared quite serious as Nacua had blood running down his face after taking a hit to the head from Henry To'oTo'o. At the time of his departure, Nacua had four targets, three catches, and 23 receiving yards. When healthy, he is a low-end fantasy WR1 in fantasy football. Davante Adams will operate as Matthew Stafford's primary target with Nacua sidelined, while Colby Parkinson, Tyler Higbee, and Tutu Atwell also get involved in the passing game.

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Dynasty | Colts quarterback Daniel Jones completed 22-of-29 passes for 272 yards with one touchdown and no interceptions in a blowout win over Miami. Dynasty Analysis: Jones was on point all day and while the stat line isn't dominant, the Colts certainly were. The story here is partially Jones but maybe more about Anthony Richardson. In short, he's not close to seeing the field any time soon as the offense simply looked better today than it had in the last two seasons. Jones will be a solid QB2 until further notice and Richardson's ADP is going to continue sinking.

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Dynasty | Colts tight end Tyler Warren had seven catches for 76 yards in his NFL debut. Dynasty Analysis: Warren was as advertised and Daniel Jones looked his way a team-leading nine times on the day. It was about as good as you could have hoped for in his NFL debut as Warren looked the part of a long-term bona-fide TE1. The Colts were sharp today and it could be a mirage but the former Penn State star certainly justified the first round rookie pick managers spent on his services in week one.

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Dynasty | Colts wide receiver Michael Pittman had six catches for 80 yards and a touchdown in a blowout win over Miami. Dynasty Analysis: Pittman had eight targets on the game and trailed only Tyler Warren (9) for the team lead on the day. Daniel Jones was solid and Pittman looks like a player who could have a bounce-back season. There could be some bumps along the road, but Pittman's ADP and ranking simply look a touch low at the moment.

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Dynasty | Dolphins quarterback Tua Tagovailoa completed just 14-of-23 passes for 114 yards with one touchdown and two interceptions in a blowout loss to the Colts. Dynasty Analysis: He also lost a fumble. Tua and the Dolphins looked like one of the worst teams in the league today and need to make some serious adjustments in short order. Tyreek Hill and Jaylen Waddle combined for just eight catches and 70 yards on the day as Miami just couldn't get anything going. On the plus side, it seems they came out of the game healthy. Tua looks like a QB2 at the moment after this uninspiring effort.

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Dynasty | Saints quarterback Spencer Rattler completed 27-of-46 passes for 214 yards in a loss to the Cardinals. Dynasty Analysis: He had an interception called back on a penalty as well. Rattler wasn't spectacular but what you won't see in the box score was a directed two-minute drive at the end of the game where he looked poised and threw what should have been a game-tying touchdown pass that was dropped. Rattler didn't exactly set the world on fire but did nothing for New Orleans to likely think about looking at Tyler Shough. He'll remain a low-end QB2 moving forward but this was actually positive.

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Dynasty | Cardinals wide receiver Marvin Harrison Jr had five catches for 71 yards and a touchdown in a win against New Orleans. Dynasty Analysis: Harrison had a disappointing 2024 season but this was a good start to his 2025 campaign. His six targets trailed only Trey McBride (9) on the day and he looks like a player ready to take a solid leap this year. While we need to see more before really getting excited, this really did look a little different than last season. Harrison will be a solid WR2 with upside moving forward.

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Dynasty | Cardinals running back Trey Benson had 69 rushing yards, one catch and six receiving yards in a win against the Saints. Dynasty Analysis: Most of his damage came on a 52-yard gain. Still, James Conner didn't exactly look explosive and Benson (9 touches) competed with Conner (16) for meaningful time. There's a long way to go in the season but the idea that this could be a "1A and 1B" situation looks relatively valid. Benson is nowhere near lineups at the moment but he looks poised to get much more work this year.

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Dynasty | Steelers quarterback Aaron Rodgers completed 22-of-30 passes for 244 yards with four touchdowns and no interceptions in a win against the Jets. Dynasty Analysis: #revenge. Rodgers still can't move very well but any notion that he'd be rusty with his new team was put to rest pretty early. He spread the ball around to seven different targets on the day and sincerely looked like he raised the ceiling of the Steelers team offensively today. It's just one week and way too early to make any predictions but this was about as good a start as you could hope for. Rodgers may indeed have one more QB1 season left in his 41-year old body.

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Tennessee Titans running back Kalel Mullings (ankle) exited during the first quarter of Sunday's game against the Denver Broncos. He is officially questionable to return. The rookie had not registered a statistic prior to his departure. Mullings entered this weekend listed as questionable with an ankle injury, so it's possible that he re-aggravated an existing ailment. With Tyjae Spears (ankle) on IR and Mullings sidelined for the moment, Tennessee's only healthy running backs are Tony Pollard and Julius Chestnut.

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Las Vegas Raiders tight end Brock Bowers (knee) told NFL Network's Tom Pelissero that he's fine and has no concerns about his injury going forward. The star tight end originally exited Sunday's game against the Patriots with a knee injury and was listed as questionable, but it sounds like he won't have any lingering effects going forward. Bowers finished Week 1 with eight targets, five catches, and 103 yards. He'll rank as a high-end TE1 heading into Week 2 against the Los Angeles Chargers. In two games against the Chargers last year, Bowers totaled 10 catches, 108 yards, and one touchdown.

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Atlanta Falcons wide receiver Drake London (shoulder) exited during the fourth quarter of Sunday's Week 1 contest against the Tampa Bay Buccaneers. He is officially questionable to return. At the time of his departure, he had caught eight of 15 targets for 55 yards. The Falcons were already playing without Darnell Mooney (shoulder), so London's exit from the contest is a loss that Atlanta cannot afford. Ray-Ray McCloud III, Kyle Pitts Sr., and Bijan Robinson will operate as Michael Penix Jr.'s primary targets until London can return.

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New Orleans Saints wide receiver Chris Olave (chest) exited during the fourth quarter of Sunday's Week 1 contest against the Arizona Cardinals. The team announced that he was questionable, but he quickly returned to the contest. Olave will re-assume his role as the Saints' No. 1 wide receiver ahead of Rashid Shaheed. Given his role in a subpar Spencer Rattler-led offense, Olave should merely be viewed as a high-end WR3/FLEX option in fantasy football.

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Las Vegas Raiders tight end Brock Bowers (knee) exited during the fourth quarter of Sunday's Week 1 contest against the New England Patriots. He is officially listed as questionable to return. The star second-year tight end was seen entering and exiting the medical tent, and he eventually returned to the sideline wearing his helmet. At the time of his departure, Bowers had caught five of his eight targets for 103 yards. Fantasy managers should continue to monitor for updates on the consensus TE1 in this year's drafts. For the time being, Michael Mayer will operate as the Raiders' No. 1 tight end.

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Tennessee Titans running back Kalel Mullings (ankle) is officially active for Sunday's Week 1 contest against the Denver Broncos. He had been listed as questionable after logging a limited practice session on Friday. The Michigan product rushed for 948 yards and 12 touchdowns during his final collegiate season last year. Although he was drafted as the Titans' projected No. 4 running back, he will carve out a larger role for the time being with Tyjae Spears (ankle) on injured reserve. Mullings and Julius Chestnut will likely rotate in as the backup options behind clear-cut starter Tony Pollard on Sunday afternoon.

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Indianapolis Colts running back Jonathan Taylor (undisclosed) exited Sunday's game against the Miami Dolphins and was seen chatting with medical personnel on the sideline, according to Kevin Bowen of 1075 The Fan. After playing 100 percent of the offensive snaps in the first half, Taylor was not on the field for a scoring drive in the fourth quarter of Week 1. The severity of Taylor's injury is unknown, and it's possible that the Colts are being extra cautious with his management because they are leading by four possessions in the final quarter. Nevertheless, fantasy managers should continue to monitor his status. At the time of Taylor's departure, he had 18 carries for 71 rushing yards, plus 27 receiving yards. D.J. Giddens has been handling backfield snaps in his absence.

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Los Angeles Rams running back Jarquez Hunter (coach's decision) is a healthy scratch for Week 1 against the Houston Texans. Although the rookie has fourth-round draft capital, it appears that the coaching staff wasn't ready to include him as a member of their gameday backfield. Hunter's absence is not necessarily a surprise, though. Yesterday, we noted that Hunter's position on the depth chart may be falling after the Rams elevated Cody Schrader from the practice squad. Indeed, Schrader will operate behind Kyren Williams and Blake Corum, while Hunter watches from the sideline. He's a fine dynasty stash but should be dropped in all redraft leagues.

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San Francisco 49ers running back Jordan James (finger) is officially inactive for Week 1 against the Seattle Seahawks. He had been listed as doubtful after logging three consecutive limited practices. James will have to wait at least one more week before making his NFL debut. The Oregon product was an effective runner in college, totaling 1,476 yards and 15 touchdowns during his final collegiate season. For now, San Francisco will operate with Brian Robinson Jr. and Isaac Guerendo in depth roles behind Christian McCaffrey.

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