

| Benched | RB | Devin Singletary NYG | Owner | Thu Nov 27 8:28am ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 8:28am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Bo Nix DEN | Owner | Tue Nov 25 4:05pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 4:05pm ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 4:05pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 4:05pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 4:05pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 4:05pm ET |
| Benched | RB | Michael Carter ARI | Owner | Thu Nov 27 10:56am ET |
| Benched | WR | Stefon Diggs NE | Owner | Thu Nov 27 10:56am ET |
| Benched | WR | Rome Odunze CHI | Owner | Thu Nov 27 10:56am ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 10:56am ET |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 10:56am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Nov 26 8:13pm ET |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 8:13pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Wed Nov 26 8:13pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Wed Nov 26 8:13pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 8:13pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 8:13pm ET |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 8:13pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 8:13pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Wed Nov 26 12:44am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 12:44am ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 12:43am ET |
| Started | RB | Tyjae Spears TEN | Owner | Wed Nov 26 12:43am ET |
| No starting lineup changes performed this week. |
| Benched | TE | Dallas Goedert PHI | Owner | Wed Nov 26 2:32pm ET |
| Started | TE | Juwan Johnson NO | Owner | Wed Nov 26 2:32pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:18pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 10:18pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 10:18pm ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 25 10:18pm ET |
| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 11:42am ET |
| Benched | K | Cam Little JAX | Owner | Thu Nov 27 11:42am ET |
| Benched | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 11:42am ET |
| Started | WR | Khalil Shakir BUF | Owner | Thu Nov 27 11:42am ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 11:42am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 11:42am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |