

| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 11:09am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 11:09am ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 8:13am ET |
| Started | WR | Xavier Worthy KC | Owner | Thu Nov 27 8:13am ET |
| Benched | QB | Jordan Love GB | Owner | Thu Nov 27 8:13am ET |
| Add TB | QB | Jordan Love GB | Owner | Thu Nov 27 8:13am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Thu Nov 27 8:13am ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 8:13am ET |
| Drop TB | WR | Tre Tucker LV | Owner | Thu Nov 27 8:13am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 8:13am ET |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 27 6:31am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 6:31am ET |
| Benched | K | Tyler Loop BAL | Owner | Thu Nov 27 11:51am ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 11:51am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 25 7:36am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 7:36am ET |
| Benched | QB | Lamar Jackson BAL | Owner | Wed Nov 26 6:56pm ET |
| Started | QB | Joe Flacco CIN | Owner | Wed Nov 26 6:56pm ET |
| No starting lineup changes performed this week. |
| Started | WR | DeVonta Smith PHI | Owner | Wed Nov 26 9:51pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 26 9:51pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 26 11:53am ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Wed Nov 26 11:53am ET |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 26 11:35am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 11:35am ET |
| Drop TB | QB | Patrick Mahomes KC | Owner | Wed Nov 26 11:35am ET |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 26 11:35am ET |
| Add TB | QB | Drake Maye NE | Owner | Wed Nov 26 11:35am ET |
| Benched | QB | Drake Maye NE | Owner | Wed Nov 26 11:35am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 26 5:12pm ET |
| Benched | TE | David Njoku CLE | Owner | Wed Nov 26 5:12pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 5:12pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 5:12pm ET |
| Benched | WR | Xavier Legette CAR | Owner | Wed Nov 26 4:34pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Wed Nov 26 4:34pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 7:40pm ET |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 27 7:40pm ET |
| No starting lineup changes performed this week. |