

| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 7:37pm ET |
| Drop TB | QB | Brock Purdy SF | Owner | Tue Nov 25 7:37pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 7:37pm ET |
| Add TB | TE | Cade Otton TB | Owner | Tue Nov 25 7:37pm ET |
| Started | QB | Bryce Young CAR | Owner | Tue Nov 25 7:37pm ET |
| Started | WR | DeAndre Hopkins BAL | Owner | Tue Nov 25 7:37pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 3:06pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 3:06pm ET |
| Add TB | WR | Jaxon Smith-Njigba SEA | Owner | Thu Nov 27 10:48am ET |
| Started | DB | Ji'Ayir Brown SF | Owner | Thu Nov 27 10:47am ET |
| Started | LB | Isaiah McDuffie GB | Owner | Thu Nov 27 10:47am ET |
| Benched | LB | Patrick Queen PIT | Owner | Thu Nov 27 10:47am ET |
| Benched | LB | Tyrel Dodson MIA | Owner | Thu Nov 27 10:47am ET |
| Drop TB | WR | Jaxon Smith-Njigba SEA | Owner | Thu Nov 27 10:47am ET |
| Started | WR | Christian Watson GB | Owner | Tue Nov 25 3:12pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 3:12pm ET |
| Started | LB | Ernest Jones SEA | Owner | Tue Nov 25 3:10pm ET |
| Started | LB | Tyrel Dodson MIA | Owner | Tue Nov 25 3:10pm ET |
| Benched | LB | Dee Winters SF | Owner | Tue Nov 25 3:10pm ET |
| Benched | LB | Akeem Davis-Gaither ARI | Owner | Tue Nov 25 3:10pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 9:58am ET |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Nov 25 9:58am ET |
| Benched | LB | Quay Walker GB | Owner | Tue Nov 25 9:58am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:58am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:58am ET |
| Started | DL | Byron Murphy II SEA | Owner | Tue Nov 25 9:58am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 9:12pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 9:12pm ET |
| Benched | LB | Claudin Cherelus CAR | Owner | Tue Nov 25 9:11pm ET |
| Started | DB | Tyson Campbell CLE | Owner | Tue Nov 25 9:11pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 8:28am ET |
| Benched | TE | Tanner Hudson CIN | Owner | Thu Nov 27 8:28am ET |
| Benched | DB | Trevon Moehrig CAR | Owner | Thu Nov 27 8:28am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Thu Nov 27 8:28am ET |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 8:28am ET |
| Started | DB | Talanoa Hufanga DEN | Owner | Thu Nov 27 8:28am ET |
| Benched | LB | Jack Gibbens NE | Owner | Tue Nov 25 9:44pm ET |
| Benched | DB | Mekhi Blackmon IND | Owner | Tue Nov 25 9:44pm ET |
| Benched | DB | Denzel Ward CLE | Owner | Tue Nov 25 9:44pm ET |
| Started | DL | Tuli Tuipulotu LAC | Owner | Tue Nov 25 9:44pm ET |
| Started | LB | Zaire Franklin IND | Owner | Tue Nov 25 9:44pm ET |
| Started | DB | Minkah Fitzpatrick MIA | Owner | Tue Nov 25 9:44pm ET |
| Benched | RB | Woody Marks HOU | Owner | Thu Nov 27 3:00pm ET |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 27 3:00pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Wed Nov 26 10:54pm ET |
| Started | RB | Woody Marks HOU | Owner | Wed Nov 26 10:54pm ET |
| Started | LB | D'Marco Jackson CHI | Owner | Thu Nov 27 12:11pm ET |
| Benched | DL | Jermaine Johnson II NYJ | Owner | Thu Nov 27 12:11pm ET |
| Started | DL | Jermaine Johnson II NYJ | Owner | Thu Nov 27 12:05pm ET |
| Benched | LB | Terrel Bernard BUF | Owner | Thu Nov 27 12:05pm ET |
| Started | DB | Evan Williams GB | Owner | Thu Nov 27 12:02pm ET |
| Benched | DB | Josh Metellus MIN | Owner | Thu Nov 27 12:02pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:22pm ET |
| Started | TE | Evan Engram DEN | Owner | Tue Nov 25 9:22pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 9:22pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 9:22pm ET |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 9:22pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 9:22pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 3:11pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 3:11pm ET |
| Benched | TE | Jake Tonges SF | Owner | Tue Nov 25 3:11pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 3:11pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 3:11pm ET |
| Started | TE | Josh Oliver MIN | Owner | Tue Nov 25 3:11pm ET |
| Add TB | RB | Jahmyr Gibbs DET | Owner | Wed Nov 26 6:55pm ET |
| Drop TB | WR | Puka Nacua LAR | Owner | Wed Nov 26 6:55pm ET |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 26 6:54pm ET |
| Benched | LB | Cody Simon ARI | Owner | Wed Nov 26 6:54pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 6:54pm ET |
| Started | LB | Daiyan Henley LAC | Owner | Wed Nov 26 6:54pm ET |
| Drop TB | QB | Lamar Jackson BAL | Owner | Tue Nov 25 4:33pm ET |
| Add TB | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:33pm ET |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 4:33pm ET |
| Benched | DB | Daxton Hill CIN | Owner | Tue Nov 25 4:33pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:33pm ET |
| Started | LB | Jordyn Brooks MIA | Owner | Tue Nov 25 4:33pm ET |
| Benched | WR | Jaylin Noel HOU | Commissioner | Thu Nov 27 10:55am ET |
| Started | RB | Devin Neal NO | Commissioner | Thu Nov 27 10:55am ET |
| Benched | WR | Matthew Golden GB | Commissioner | Thu Nov 27 10:56am ET |
| Benched | DL | Jalen Carter PHI | Commissioner | Thu Nov 27 10:56am ET |
| Started | WR | Ladd McConkey LAC | Commissioner | Thu Nov 27 10:56am ET |
| Started | DB | Quan Martin WAS | Commissioner | Thu Nov 27 10:56am ET |
| Add TB | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 11:49pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 11:49pm ET |
| Drop TB | QB | Caleb Williams CHI | Owner | Thu Nov 27 11:49pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Thu Nov 27 11:49pm ET |
| Started | DB | Derwin James LAC | Owner | Thu Nov 27 1:53am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 1:53am ET |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 1:53am ET |
| Benched | DB | DaRon Bland DAL | Owner | Thu Nov 27 1:53am ET |
| Benched | TE | Gunnar Helm TEN | Owner | Thu Nov 27 1:53am ET |
| Benched | WR | Cooper Kupp SEA | Owner | Thu Nov 27 1:53am ET |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 12:13pm ET |
| Benched | RB | Tank Bigsby PHI | Owner | Tue Nov 25 12:13pm ET |
| Benched | LB | Christian Rozeboom CAR | Owner | Tue Nov 25 12:13pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 12:13pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 25 12:13pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 12:13pm ET |
| Started | DL | Laiatu Latu IND | Owner | Tue Nov 25 12:13pm ET |