

| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 9:52pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 9:52pm ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Thu Nov 27 10:13am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 10:13am ET |
| Benched | D/ST | Houston Texans HOU | Owner | Thu Nov 27 10:07am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 10:07am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 12:28pm ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 12:28pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 8:13pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 8:13pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 8:13pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 8:13pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Tyler Warren IND | Owner | Thu Nov 27 12:34pm ET |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 12:34pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 9:46am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:46am ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 11:31am ET |
| Started | WR | Chris Olave NO | Owner | Thu Nov 27 11:31am ET |
| Benched | QB | Caleb Williams CHI | Owner | Thu Nov 27 12:30pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 12:30pm ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 12:30pm ET |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 12:30pm ET |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 10:38pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 10:38pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 10:22pm ET |
| Benched | K | Cairo Santos CHI | Owner | Wed Nov 26 10:22pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Wed Nov 26 10:22pm ET |
| Started | K | Wil Lutz DEN | Owner | Wed Nov 26 10:22pm ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Tue Nov 25 8:27pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:27pm ET |