

| Benched | D/ST | New Orleans Saints NO | Owner | Wed Nov 26 8:50pm ET |
| Started | D/ST | New England Patriots NE | Owner | Wed Nov 26 8:50pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 8:49pm ET |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 8:49pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 8:49pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 8:49pm ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 27 3:19pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 3:19pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 1:06pm ET |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 1:06pm ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 11:10am ET |
| Benched | WR | DeAndre Hopkins BAL | Owner | Tue Nov 25 11:10am ET |
| Started | QB | Josh Allen BUF | Owner | Tue Nov 25 11:10am ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 11:10am ET |
| Benched | TE | Hunter Henry NE | Owner | Fri Nov 28 3:02am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Fri Nov 28 3:02am ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 3:27am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 3:27am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Wed Nov 26 7:15pm ET |
| Benched | WR | Christian Watson GB | Owner | Wed Nov 26 7:15pm ET |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 7:15pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 7:15pm ET |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 7:15pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 7:15pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 25 1:30pm ET |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 25 1:30pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 1:30pm ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 25 1:30pm ET |
| Benched | QB | Jordan Love GB | Owner | Thu Nov 27 12:12pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Thu Nov 27 12:12pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 25 7:14am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:14am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 7:13am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 25 7:13am ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Green Bay Packers GB | Owner | Wed Nov 26 10:48pm ET |
| Started | D/ST | Miami Dolphins MIA | Owner | Wed Nov 26 10:48pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 11:20am ET |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 26 11:20am ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 10:10am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 10:10am ET |
| Started | RB | Michael Carter ARI | Owner | Sat Nov 29 9:17am ET |
| Benched | RB | Omarion Hampton LAC | Owner | Sat Nov 29 9:17am ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 2:26pm ET |
| Benched | QB | Lamar Jackson BAL | Owner | Thu Nov 27 2:26pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Nov 25 4:33pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 4:33pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 9:22am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:22am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 9:22am ET |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 9:22am ET |