

| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 27 9:25am ET |
| Started | WR | Xavier Worthy KC | Owner | Thu Nov 27 9:25am ET |
| Benched | LB | Quincy Williams NYJ | Owner | Tue Nov 25 10:10pm ET |
| Started | LB | Akeem Davis-Gaither ARI | Owner | Tue Nov 25 10:10pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 10:08pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 10:08pm ET |
| No starting lineup changes performed this week. |
| Benched | DB | Derek Stingley Jr. HOU | Owner | Wed Nov 26 10:43am ET |
| Started | LB | Nik Bonitto DEN | Owner | Wed Nov 26 10:43am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 10:53pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 10:53pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Terrance Ferguson LAR | Owner | Thu Nov 27 1:51am ET |
| Benched | LB | Logan Wilson DAL | Owner | Thu Nov 27 1:51am ET |
| Benched | DB | Tyler Nubin NYG | Owner | Thu Nov 27 1:51am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 1:51am ET |
| Started | DB | Talanoa Hufanga DEN | Owner | Thu Nov 27 1:51am ET |
| Started | DB | Derwin James LAC | Owner | Thu Nov 27 1:51am ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 3:09pm ET |
| Benched | DB | Alontae Taylor NO | Owner | Tue Nov 25 3:09pm ET |
| Started | QB | Tyrod Taylor NYJ | Owner | Tue Nov 25 3:09pm ET |
| Started | DB | Xavier Watts ATL | Owner | Tue Nov 25 3:09pm ET |
| Benched | QB | Jared Goff DET | Owner | Thu Nov 27 12:27pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 12:27pm ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 12:27pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 12:27pm ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 9:50am ET |
| Benched | RB | Jaylen Warren PIT | Owner | Thu Nov 27 9:50am ET |
| Started | LB | Isaiah McDuffie GB | Owner | Thu Nov 27 9:36am ET |
| Started | LB | D'Marco Jackson CHI | Owner | Thu Nov 27 9:36am ET |
| Benched | DB | Reed Blankenship PHI | Owner | Thu Nov 27 9:36am ET |
| Benched | LB | Dee Winters SF | Owner | Thu Nov 27 9:36am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 3:07pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 3:07pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 3:07pm ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 3:07pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 9:14pm ET |
| Started | WR | Christian Watson GB | Owner | Tue Nov 25 9:14pm ET |
| Benched | DL | Jadeveon Clowney DAL | Owner | Tue Nov 25 5:28pm ET |
| Started | DL | Devonte Wyatt GB | Owner | Tue Nov 25 5:28pm ET |
| Started | DB | Evan Williams GB | Owner | Thu Nov 27 12:01pm ET |
| Benched | DL | Nic Scourton CAR | Owner | Thu Nov 27 12:01pm ET |
| Started | TE | Colston Loveland CHI | Owner | Thu Nov 27 11:59am ET |
| Benched | WR | Drake London ATL | Owner | Thu Nov 27 11:59am ET |
| Started | LB | Jordyn Brooks MIA | Owner | Tue Nov 25 9:25pm ET |
| Started | DL | Nic Scourton CAR | Owner | Tue Nov 25 9:25pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 9:25pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 9:25pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 9:25pm ET |
| Benched | DB | Trevon Moehrig CAR | Owner | Tue Nov 25 9:25pm ET |
| Benched | LB | Payton Wilson PIT | Owner | Tue Nov 25 9:25pm ET |
| Benched | WR | Xavier Hutchinson HOU | Owner | Tue Nov 25 9:25pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 9:25pm ET |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 9:25pm ET |
| Benched | DL | Joey Bosa BUF | Owner | Tue Nov 25 7:48am ET |
| Benched | LB | Demetrius Knight Jr. CIN | Owner | Tue Nov 25 7:48am ET |
| Benched | DB | Coby Bryant SEA | Owner | Tue Nov 25 7:48am ET |
| Started | DL | K'Lavon Chaisson NE | Owner | Tue Nov 25 7:48am ET |
| Started | LB | Tyrel Dodson MIA | Owner | Tue Nov 25 7:48am ET |
| Started | DB | Geno Stone CIN | Owner | Tue Nov 25 7:48am ET |
| Benched | QB | Cam Ward TEN | Owner | Tue Nov 25 10:00am ET |
| Started | LB | Cody Barton TEN | Owner | Tue Nov 25 10:00am ET |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 25 10:00am ET |
| Started | WR | Jordan Addison MIN | Owner | Tue Nov 25 10:00am ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 10:00am ET |
| Benched | LB | Tremaine Edmunds CHI | Owner | Tue Nov 25 10:00am ET |
| Benched | DL | Jeffery Simmons TEN | Owner | Tue Nov 25 10:00am ET |
| Benched | TE | Colby Parkinson LAR | Owner | Tue Nov 25 10:00am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:00am ET |
| Started | DB | Minkah Fitzpatrick MIA | Owner | Tue Nov 25 10:00am ET |
| Started | DB | Jalen Thompson ARI | Owner | Thu Nov 27 11:01am ET |
| Benched | DB | Jalen Ramsey PIT | Owner | Thu Nov 27 11:01am ET |
| Started | LB | Bobby Wagner WAS | Owner | Thu Nov 27 10:57am ET |
| Started | DL | Justin Eboigbe LAC | Owner | Thu Nov 27 10:57am ET |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 10:57am ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 10:57am ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 10:57am ET |
| Benched | DL | Cameron Jordan NO | Owner | Thu Nov 27 10:57am ET |
| Benched | DL | Josh Allen JAX | Owner | Thu Nov 27 10:57am ET |
| Benched | TE | Jonnu Smith PIT | Owner | Thu Nov 27 10:57am ET |
| Benched | WR | Ryan Flournoy DAL | Owner | Thu Nov 27 10:57am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Thu Nov 27 10:57am ET |
| Benched | DB | Keisean Nixon GB | Owner | Thu Nov 27 8:27am ET |
| Started | DB | Nate Wiggins BAL | Owner | Thu Nov 27 8:27am ET |