

| Benched | WR | Xavier Worthy KC | Owner | Thu Nov 27 11:33am CT |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 11:33am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 11:33am CT |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Wed Nov 26 11:52pm CT |
| Started | D/ST | Miami Dolphins MIA | Owner | Wed Nov 26 11:52pm CT |
| Benched | WR | Darius Slayton NYG | Owner | Tue Nov 25 9:39am CT |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 9:39am CT |
| Benched | QB | Lamar Jackson BAL | Owner | Tue Nov 25 12:20pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 12:20pm CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 8:04am CT |
| Started | RB | Kareem Hunt KC | Owner | Tue Nov 25 8:04am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 3:35pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 3:35pm CT |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 3:34pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 3:34pm CT |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 10:36am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 10:36am CT |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 10:35am CT |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 10:35am CT |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 25 10:35am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 10:35am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 10:35am CT |
| Started | D/ST | Houston Texans HOU | Owner | Tue Nov 25 10:35am CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 12:05pm CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 12:05pm CT |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 12:04pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 12:04pm CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 3:41am CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 2:57am CT |
| Benched | WR | Sterling Shepard TB | Owner | Wed Nov 26 2:57am CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 2:57am CT |
| Started | TE | Jake Ferguson DAL | Owner | Wed Nov 26 2:57am CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 10:50pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 10:50pm CT |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 1:15pm CT |
| Started | WR | Jameson Williams DET | Owner | Wed Nov 26 1:15pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 11:33am CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 11:33am CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 11:33am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 11:33am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 9:25am CT |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 9:25am CT |
| Benched | TE | Cade Otton TB | Owner | Thu Nov 27 9:25am CT |
| Started | RB | Quinshon Judkins CLE | Owner | Thu Nov 27 9:25am CT |
| Started | WR | Jayden Higgins HOU | Owner | Thu Nov 27 9:25am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 9:25am CT |
| Started | D/ST | San Francisco 49ers SF | Owner | Thu Nov 27 9:25am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Bhayshul Tuten JAX | Owner | Wed Nov 26 11:23pm CT |
| Started | RB | Dylan Sampson CLE | Owner | Wed Nov 26 11:23pm CT |
| Benched | D/ST | New Orleans Saints NO | Owner | Wed Nov 26 11:23pm CT |
| Started | D/ST | Indianapolis Colts IND | Owner | Wed Nov 26 11:23pm CT |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 8:18am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:18am CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 11:20am CT |
| Started | WR | Zay Flowers BAL | Owner | Thu Nov 27 11:20am CT |
| Benched | WR | Zay Flowers BAL | Owner | Wed Nov 26 1:34pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 1:34pm CT |