

| Benched | WR | Michael Wilson ARI | Owner | Thu Nov 27 10:52am ET |
| Started | RB | Javonte Williams DAL | Owner | Thu Nov 27 10:52am ET |
| Drop TB | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 10:52am ET |
| Benched | RB | Javonte Williams DAL | Owner | Thu Nov 27 9:24am ET |
| Started | WR | Michael Wilson ARI | Owner | Thu Nov 27 9:24am ET |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 8:27pm ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 8:27pm ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 25 11:22pm ET |
| Started | D/ST | Arizona Cardinals ARI | Owner | Tue Nov 25 11:22pm ET |
| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 9:17am ET |
| Drop TB | K | Riley Patterson MIA | Owner | Wed Nov 26 9:17am ET |
| Started | K | Riley Patterson MIA | Owner | Wed Nov 26 9:17am ET |
| Started | RB | Kareem Hunt KC | Owner | Wed Nov 26 9:17am ET |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 9:17am ET |
| Benched | D/ST | Indianapolis Colts IND | Owner | Wed Nov 26 9:17am ET |
| Add TB | K | Eddy Pineiro SF | Owner | Wed Nov 26 9:17am ET |
| Benched | K | Eddy Pineiro SF | Owner | Wed Nov 26 9:17am ET |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 9:17am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 9:17am ET |
| Started | WR | Kayshon Boutte NE | Owner | Tue Nov 25 9:46am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 9:46am ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 7:35am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 7:35am ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 7:24am ET |
| Started | WR | Romeo Doubs GB | Owner | Tue Nov 25 7:24am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:24am ET |
| Benched | K | Chad Ryland ARI | Owner | Tue Nov 25 7:24am ET |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 7:24am ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 7:24am ET |
| Benched | WR | Rome Odunze CHI | Owner | Thu Nov 27 1:46pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 1:46pm ET |
| Add TB | K | Brandon Aubrey DAL | Owner | Thu Nov 27 1:46pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 8:49pm ET |
| Benched | RB | Devin Neal NO | Owner | Wed Nov 26 12:18pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 12:18pm ET |
| Started | WR | Alec Pierce IND | Owner | Wed Nov 26 12:18pm ET |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 12:18pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 12:18pm ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 12:15pm ET |
| Benched | QB | Matthew Stafford LAR | Owner | Wed Nov 26 10:11pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 10:11pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Wed Nov 26 2:47pm ET |
| Benched | TE | Hunter Henry NE | Owner | Wed Nov 26 2:47pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 2:47pm ET |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 2:47pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 5:23pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 5:23pm ET |