

| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 12:32am ET |
| Benched | WR | Tez Johnson TB | Owner | Wed Nov 26 12:18am ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 12:18am ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 9:17am ET |
| Benched | K | Brandon Aubrey DAL | Owner | Tue Nov 25 9:17am ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Nov 25 9:17am ET |
| Started | K | Tyler Loop BAL | Owner | Tue Nov 25 9:17am ET |
| Started | K | Jake Bates DET | Owner | Thu Nov 27 12:11pm ET |
| Benched | D/ST | Houston Texans HOU | Owner | Wed Nov 26 6:30pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Wed Nov 26 6:30pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 5:25pm ET |
| Started | RB | Jordan Mason MIN | Owner | Thu Nov 27 5:25pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Thu Nov 27 5:25pm ET |
| Benched | WR | Sterling Shepard TB | Owner | Thu Nov 27 5:25pm ET |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 5:25pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 5:25pm ET |
| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 11:18am ET |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 11:18am ET |
| Started | QB | C.J. Stroud HOU | Owner | Wed Nov 26 11:18am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 11:18am ET |
| Benched | QB | Jordan Love GB | Owner | Wed Nov 26 10:16pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Nov 26 10:16pm ET |
| Benched | K | Brandon McManus GB | Owner | Wed Nov 26 10:16pm ET |
| Benched | D/ST | Chicago Bears CHI | Owner | Wed Nov 26 10:16pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 10:16pm ET |
| Started | WR | Rome Odunze CHI | Owner | Wed Nov 26 10:16pm ET |
| Started | K | Michael Badgley IND | Owner | Wed Nov 26 10:16pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Wed Nov 26 10:16pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 26 9:50pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 9:50pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Wed Nov 26 9:49pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 9:49pm ET |
| Benched | QB | Geno Smith LV | Owner | Wed Nov 26 7:24pm ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 7:24pm ET |
| Started | TE | Colston Loveland CHI | Owner | Fri Nov 28 2:13pm ET |
| Started | WR | Kayshon Boutte NE | Owner | Fri Nov 28 2:13pm ET |
| Benched | TE | Hunter Henry NE | Owner | Fri Nov 28 2:13pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Fri Nov 28 2:13pm ET |
| Started | WR | D.J. Moore CHI | Owner | Fri Nov 28 2:02pm ET |
| Benched | TE | Theo Johnson NYG | Owner | Fri Nov 28 2:02pm ET |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 8:08am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Thu Nov 27 8:08am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 11:09am ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Wed Nov 26 11:09am ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 25 10:05am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:05am ET |
| Benched | RB | Justice Hill BAL | Owner | Thu Nov 27 4:11am ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 4:11am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 4:11am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 4:11am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Thu Nov 27 11:48am ET |
| Benched | WR | Cooper Kupp SEA | Owner | Thu Nov 27 11:48am ET |
| Benched | TE | Noah Fant CIN | Owner | Thu Nov 27 11:48am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 11:48am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 11:48am ET |
| Started | TE | Isaiah Likely BAL | Owner | Thu Nov 27 11:48am ET |