

| Benched | QB | Tyler Shough NO | Owner | Fri Nov 28 8:37pm ET |
| Started | QB | Baker Mayfield TB | Owner | Fri Nov 28 8:37pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 4:15pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 4:15pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 4:15pm ET |
| Started | QB | Tyler Shough NO | Owner | Tue Nov 25 4:15pm ET |
| Started | RB | Kareem Hunt KC | Owner | Tue Nov 25 4:15pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:15pm ET |
| Benched | QB | Cam Ward TEN | Owner | Thu Nov 27 11:22am ET |
| Benched | WR | Xavier Legette CAR | Owner | Thu Nov 27 11:22am ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 11:22am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 11:22am ET |
| Benched | TE | Pat Freiermuth PIT | Owner | Thu Nov 27 8:34am ET |
| Started | TE | Evan Engram DEN | Owner | Thu Nov 27 8:34am ET |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 9:20pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 9:19pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 9:19pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 9:19pm ET |
| Benched | RB | Nick Chubb HOU | Owner | Tue Nov 25 9:18pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:18pm ET |
| Benched | RB | Dylan Sampson CLE | Owner | Tue Nov 25 7:03pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:03pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 2:08pm ET |
| Started | RB | Dylan Sampson CLE | Owner | Tue Nov 25 2:08pm ET |
| Benched | WR | Calvin Austin III PIT | Owner | Wed Nov 26 5:50pm ET |
| Benched | WR | Gabriel Davis BUF | Owner | Wed Nov 26 5:50pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 5:50pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 5:50pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Wed Nov 26 12:51pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 12:51pm ET |
| Benched | QB | Davis Mills HOU | Owner | Wed Nov 26 12:50pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 12:50pm ET |
| Benched | WR | Adonai Mitchell NYJ | Owner | Wed Nov 26 12:50pm ET |
| Started | RB | Jaylen Warren PIT | Owner | Wed Nov 26 12:50pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 12:50pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 12:50pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Zonovan Knight ARI | Owner | Sat Nov 29 12:16am ET |
| Started | RB | Zach Charbonnet SEA | Owner | Sat Nov 29 12:16am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 5:30pm ET |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 25 5:30pm ET |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 5:30pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 5:30pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 5:30pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 5:30pm ET |
| Benched | QB | Mason Rudolph PIT | Owner | Wed Nov 26 3:43pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Wed Nov 26 3:43pm ET |
| Started | WR | Cooper Kupp SEA | Owner | Wed Nov 26 3:43pm ET |
| Started | RB | Devin Singletary NYG | Owner | Wed Nov 26 3:43pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Wed Nov 26 3:43pm ET |
| Benched | TE | Taysom Hill NO | Owner | Wed Nov 26 3:43pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 26 3:43pm ET |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 3:43pm ET |
| Benched | WR | Marquise Brown KC | Owner | Wed Nov 26 3:43pm ET |
| Started | TE | Colby Parkinson LAR | Owner | Wed Nov 26 3:43pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Sat Nov 29 5:04pm ET |
| Benched | QB | Tyrod Taylor NYJ | Owner | Sat Nov 29 5:04pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Sat Nov 29 5:01pm ET |
| Benched | RB | Bucky Irving TB | Owner | Sat Nov 29 5:01pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 9:50pm ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 9:50pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 9:49pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 9:49pm ET |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 9:49pm ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 9:49pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 11:13pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 11:13pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 6:11pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 6:11pm ET |