

| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 7:14am CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Sat Nov 29 7:14am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Sat Nov 29 7:12am CT |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Sat Nov 29 7:12am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:14pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 8:14pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:14pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:14pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 8:14pm CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 8:14pm CT |
| Benched | RB | Chuba Hubbard CAR | Owner | Thu Nov 27 11:36am CT |
| Benched | WR | Kayshon Boutte NE | Owner | Thu Nov 27 11:36am CT |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 11:36am CT |
| Started | WR | Michael Wilson ARI | Owner | Thu Nov 27 11:36am CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 11:35am CT |
| Started | QB | Cam Ward TEN | Owner | Thu Nov 27 11:35am CT |
| Benched | RB | Tony Pollard TEN | Owner | Tue Nov 25 9:14am CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 9:14am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:14am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 9:14am CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Omarion Hampton LAC | Commissioner | Fri Nov 28 9:47pm CT |
| Started | RB | Kenneth Walker III SEA | Commissioner | Fri Nov 28 9:47pm CT |
| Benched | RB | Kenneth Walker III SEA | Commissioner | Thu Nov 27 3:47pm CT |
| Started | RB | Omarion Hampton LAC | Commissioner | Thu Nov 27 3:47pm CT |
| Benched | QB | Shedeur Sanders CLE | Commissioner | Thu Nov 27 3:47pm CT |
| Benched | RB | Alvin Kamara NO | Commissioner | Thu Nov 27 3:47pm CT |
| Started | RB | Jaylen Warren PIT | Commissioner | Thu Nov 27 3:47pm CT |
| Started | WR | Ja'Marr Chase CIN | Commissioner | Thu Nov 27 3:47pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 10:59am CT |
| Benched | WR | Demario Douglas NE | Owner | Wed Nov 26 10:59am CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 10:59am CT |
| Started | WR | Terry McLaurin WAS | Owner | Wed Nov 26 10:59am CT |
| Benched | QB | Jameis Winston NYG | Owner | Fri Nov 28 5:38pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Fri Nov 28 5:38pm CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 11:43am CT |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 11:43am CT |
| Benched | QB | Geno Smith LV | Owner | Thu Nov 27 9:28am CT |
| Benched | WR | Cooper Kupp SEA | Owner | Thu Nov 27 9:28am CT |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 9:28am CT |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 9:28am CT |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 9:28am CT |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 9:28am CT |
| No starting lineup changes performed this week. |