

| Benched | WR | Keenan Allen LAC | Owner | Sat Nov 29 6:53am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 6:53am ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 4:48pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 4:48pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 4:48pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:48pm ET |
| Benched | TE | Hunter Henry NE | Owner | Thu Nov 27 7:49am ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 7:49am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Christian Watson GB | Owner | Wed Nov 26 10:46pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 10:46pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Luther Burden III CHI | Owner | Fri Nov 28 1:44pm ET |
| Benched | WR | Tez Johnson TB | Owner | Fri Nov 28 1:44pm ET |
| Started | RB | Devon Achane MIA | Owner | Fri Nov 28 1:44pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Fri Nov 28 1:44pm ET |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 6:58pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 6:58pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:35pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 8:35pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 8:35pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 8:35pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 12:16pm ET |
| Started | WR | Pat Bryant DEN | Owner | Thu Nov 27 12:16pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 5:33pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 5:33pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 5:33pm ET |
| Benched | TE | Pat Freiermuth PIT | Owner | Tue Nov 25 5:33pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 5:33pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 5:33pm ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 5:33pm ET |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 5:33pm ET |
| Benched | QB | Tyrod Taylor NYJ | Owner | Tue Nov 25 8:41am ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 8:41am ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 8:41am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:41am ET |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 8:51am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 8:51am ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 8:51am ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 8:51am ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 26 11:35pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 11:35pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Wed Nov 26 11:33pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Wed Nov 26 11:33pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 11:33pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 11:33pm ET |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 5:02pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 5:02pm ET |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 25 5:02pm ET |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 25 5:02pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 5:02pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 5:02pm ET |