

| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 5:06pm ET |
| Benched | RB | Michael Carter ARI | Owner | Tue Nov 25 5:06pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 5:06pm ET |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 25 5:06pm ET |
| Started | QB | Daniel Jones IND | Owner | Tue Nov 25 5:06pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 5:06pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 5:06pm ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 5:06pm ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 2:38pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 2:38pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jameis Winston NYG | Owner | Wed Nov 26 11:46am ET |
| Started | QB | Marcus Mariota WAS | Owner | Wed Nov 26 11:46am ET |
| No starting lineup changes performed this week. |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 3:20pm ET |
| Benched | QB | Drake Maye NE | Owner | Tue Nov 25 3:20pm ET |
| Started | TE | Isaiah Likely BAL | Owner | Tue Nov 25 3:20pm ET |
| Started | WR | Adonai Mitchell NYJ | Owner | Tue Nov 25 3:20pm ET |
| Started | QB | Bryce Young CAR | Owner | Tue Nov 25 3:20pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 3:20pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 3:20pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 3:20pm ET |
| Started | WR | Josh Downs IND | Owner | Tue Nov 25 3:18pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 3:18pm ET |
| Benched | TE | Tyler Warren IND | Owner | Tue Nov 25 9:22pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:22pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 9:21pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 9:21pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 11:15am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Thu Nov 27 11:15am ET |
| Benched | WR | Marquise Brown KC | Owner | Thu Nov 27 11:15am ET |
| Started | QB | Max Brosmer MIN | Owner | Thu Nov 27 11:15am ET |
| Started | RB | Jaleel McLaughlin DEN | Owner | Thu Nov 27 11:15am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 11:15am ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 1:05am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 1:05am ET |
| Started | TE | Mason Taylor NYJ | Owner | Thu Nov 27 3:51pm ET |
| Benched | TE | AJ Barner SEA | Owner | Thu Nov 27 3:51pm ET |
| Started | TE | AJ Barner SEA | Owner | Tue Nov 25 3:39pm ET |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 25 3:39pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 3:39pm ET |
| Started | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 3:39pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Nov 25 3:39pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 3:39pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 3:39pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 3:39pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Fri Nov 28 2:55am ET |
| Started | RB | Bucky Irving TB | Owner | Fri Nov 28 2:55am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 9:34am ET |
| Started | WR | Luther Burden III CHI | Owner | Tue Nov 25 9:34am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 9:33am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 9:33am ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 7:17pm ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 7:17pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 7:17pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:17pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 7:17pm ET |
| Started | WR | Romeo Doubs GB | Owner | Tue Nov 25 7:17pm ET |