

| Benched | K | Cam Little JAX | Owner | Tue Nov 25 7:59pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 7:59pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 7:57pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:57pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 7:50pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 26 7:50pm ET |
| Benched | RB | Nick Chubb HOU | Owner | Tue Nov 25 10:39am ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 10:39am ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 10:39am ET |
| Started | WR | Chris Olave NO | Owner | Tue Nov 25 10:39am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 5:04pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 5:04pm ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 5:04pm ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Tue Nov 25 5:04pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:04pm ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Tue Nov 25 5:04pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 11:11am ET |
| Started | WR | Darius Slayton NYG | Owner | Wed Nov 26 11:11am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 10:51pm ET |
| Benched | WR | Justin Jefferson MIN | Owner | Wed Nov 26 10:51pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 10:51pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 10:51pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 5:05pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 5:05pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Thu Nov 27 12:30pm ET |
| Benched | WR | Cooper Kupp SEA | Owner | Thu Nov 27 12:30pm ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 12:30pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Thu Nov 27 12:30pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Thu Nov 27 9:18am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 9:18am ET |
| Started | K | Chase McLaughlin TB | Owner | Thu Nov 27 9:17am ET |
| Benched | QB | Geno Smith LV | Owner | Wed Nov 26 7:21pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Wed Nov 26 7:21pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 7:21pm ET |
| Started | TE | Brenton Strange JAX | Owner | Wed Nov 26 7:21pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Thu Nov 27 12:11pm ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 12:11pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 12:10pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 12:10pm ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 10:41pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 10:41pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 10:41pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 10:41pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 4:15pm ET |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 4:15pm ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 4:15pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:15pm ET |