

| Started | QB | Baker Mayfield TB | Owner | Fri Nov 28 9:21pm ET |
| Benched | QB | Tua Tagovailoa MIA | Owner | Fri Nov 28 9:21pm ET |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 4:29pm ET |
| Benched | WR | Keenan Allen LAC | Owner | Thu Nov 27 4:29pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 5:03pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 5:03pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 5:03pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 5:03pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 5:03pm ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 5:03pm ET |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 5:03pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 5:03pm ET |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 12:36pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 12:36pm ET |
| Benched | RB | Blake Corum LAR | Owner | Tue Nov 25 2:26pm ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 2:26pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 2:26pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 2:26pm ET |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 25 2:26pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 2:26pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 2:26pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 2:26pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Drake London ATL | Owner | Fri Nov 28 3:35pm ET |
| Started | WR | Chimere Dike TEN | Owner | Fri Nov 28 3:35pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 5:10pm ET |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 25 5:10pm ET |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 5:09pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 5:09pm ET |
| Started | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 5:09pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 5:09pm ET |
| Benched | RB | Nick Chubb HOU | Owner | Tue Nov 25 9:07am ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 9:07am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:07am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:07am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 8:04am ET |
| Started | RB | Bhayshul Tuten JAX | Owner | Thu Nov 27 8:04am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 7:19am ET |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 7:19am ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 7:19am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 7:19am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 7:19am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:19am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 5:00pm ET |
| Benched | RB | Travis Etienne JAX | Owner | Tue Nov 25 4:57pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 4:57pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 4:57pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 4:48pm ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 25 4:48pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 2:56pm ET |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 2:56pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 2:56pm ET |
| Started | WR | Pat Bryant DEN | Owner | Tue Nov 25 2:56pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 9:11am ET |
| Benched | TE | Theo Johnson NYG | Owner | Sat Nov 29 9:11am ET |
| Started | TE | Theo Johnson NYG | Owner | Thu Nov 27 8:37pm ET |
| Benched | TE | Hunter Henry NE | Owner | Thu Nov 27 8:37pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 8:55pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Wed Nov 26 8:55pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 12:56pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 26 12:56pm ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 25 8:23pm ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 8:23pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 12:01pm ET |
| Benched | RB | Brian Robinson Jr. SF | Owner | Tue Nov 25 12:01pm ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 25 10:51am ET |
| Benched | WR | Devaughn Vele NO | Owner | Tue Nov 25 10:51am ET |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 10:51am ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 10:51am ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 7:15am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 7:15am ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:15am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:15am ET |
| Benched | RB | D'Andre Swift CHI | Owner | Fri Nov 28 1:04am ET |
| Started | WR | Terry McLaurin WAS | Owner | Fri Nov 28 1:04am ET |
| Benched | QB | Caleb Williams CHI | Owner | Fri Nov 28 1:03am ET |
| Started | QB | Jacoby Brissett ARI | Owner | Fri Nov 28 1:03am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Thu Nov 27 8:30am ET |
| Started | QB | Caleb Williams CHI | Owner | Thu Nov 27 8:30am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:10am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 8:10am ET |