

| Benched | QB | Bryce Young CAR | Owner | Thu Nov 27 1:02pm ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 1:02pm ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 10:49am ET |
| Started | WR | Christian Watson GB | Owner | Thu Nov 27 10:49am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 4:14pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 4:14pm ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 4:14pm ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 25 4:14pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 4:14pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 4:14pm ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 8:16am ET |
| Benched | WR | Xavier Worthy KC | Owner | Thu Nov 27 8:16am ET |
| Started | TE | Darnell Washington PIT | Owner | Wed Nov 26 11:04pm ET |
| Benched | TE | Theo Johnson NYG | Owner | Wed Nov 26 11:04pm ET |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 7:24pm ET |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 7:24pm ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 1:32pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 1:32pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 1:32pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 1:32pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 1:32pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 1:32pm ET |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 1:32pm ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 1:32pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Wed Nov 26 10:39pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 10:39pm ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 1:14pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:14pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 8:38am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:38am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 8:38am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:38am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 9:02pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 9:02pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 9:02pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:02pm ET |
| Benched | K | Will Reichard MIN | Owner | Wed Nov 26 11:13am ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Wed Nov 26 11:13am ET |
| Benched | WR | Cooper Kupp SEA | Owner | Tue Nov 25 5:37pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 5:37pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 5:36pm ET |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 25 5:36pm ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 5:36pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 5:36pm ET |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 5:36pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 5:36pm ET |
| Benched | D/ST | Houston Texans HOU | Owner | Wed Nov 26 1:46am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 1:46am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 6:36pm ET |
| Benched | RB | Blake Corum LAR | Owner | Tue Nov 25 6:36pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 6:36pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 6:36pm ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 6:36pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 6:36pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Caleb Williams CHI | Owner | Thu Nov 27 5:44pm ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 5:44pm ET |