

| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 1:13pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 1:13pm CT |
| Benched | QB | Tyrod Taylor NYJ | Owner | Tue Nov 25 1:13pm CT |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 1:13pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 1:13pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 1:13pm CT |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 7:24am CT |
| Started | TE | Juwan Johnson NO | Owner | Thu Nov 27 7:24am CT |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 7:46am CT |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 7:46am CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 7:46am CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 7:46am CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 4:09pm CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 4:09pm CT |
| Benched | TE | Dawson Knox BUF | Owner | Tue Nov 25 4:09pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 4:09pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:09pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 4:09pm CT |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 2:44pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Wed Nov 26 2:44pm CT |
| Benched | RB | Michael Carter ARI | Owner | Tue Nov 25 9:44am CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 9:44am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 8:16am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 8:16am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Chris Godwin TB | Owner | Tue Nov 25 9:49am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:49am CT |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 5:09pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 5:09pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 12:32am CT |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 26 12:32am CT |
| Benched | TE | Jake Ferguson DAL | Owner | Wed Nov 26 12:32am CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 12:32am CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 12:32am CT |
| Started | WR | Drake London ATL | Owner | Wed Nov 26 12:32am CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:41pm CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 10:41pm CT |
| Started | WR | Jayden Higgins HOU | Owner | Sat Nov 29 11:57am CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Sat Nov 29 11:57am CT |
| Started | RB | Tyler Allgeier ATL | Owner | Sat Nov 29 8:45am CT |
| Benched | WR | Parker Washington JAX | Owner | Sat Nov 29 8:45am CT |
| Started | TE | David Njoku CLE | Owner | Sat Nov 29 8:14am CT |
| Benched | TE | Evan Engram DEN | Owner | Sat Nov 29 8:14am CT |
| Started | TE | Evan Engram DEN | Owner | Thu Nov 27 2:53am CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 7:55pm CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 26 7:55pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 11:06am CT |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 11:06am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 9:44am CT |
| Benched | WR | Jayden Higgins HOU | Owner | Tue Nov 25 9:44am CT |