

| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 11:57pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 11:57pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 12:50am ET |
| Started | TE | Travis Kelce KC | Owner | Wed Nov 26 10:15pm ET |
| Benched | WR | Malik Washington MIA | Owner | Wed Nov 26 10:15pm ET |
| Started | RB | Chase Brown CIN | Owner | Wed Nov 26 11:36am ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 11:36am ET |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 26 11:36am ET |
| Started | WR | Rashee Rice KC | Owner | Wed Nov 26 11:36am ET |
| Started | WR | Malik Washington MIA | Owner | Wed Nov 26 11:36am ET |
| Started | TE | Hunter Henry NE | Owner | Wed Nov 26 11:36am ET |
| Started | K | Jason Myers SEA | Owner | Wed Nov 26 11:36am ET |
| Started | D/ST | Detroit Lions DET | Owner | Wed Nov 26 11:36am ET |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 26 11:36am ET |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 11:32am ET |
| Benched | K | Jason Myers SEA | Owner | Wed Nov 26 11:32am ET |
| Benched | QB | Patrick Mahomes KC | Owner | Wed Nov 26 11:32am ET |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 26 11:32am ET |
| Benched | RB | Josh Jacobs GB | Owner | Wed Nov 26 11:32am ET |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 11:32am ET |
| Benched | WR | Tez Johnson TB | Owner | Wed Nov 26 11:32am ET |
| Benched | WR | Rashee Rice KC | Owner | Wed Nov 26 11:32am ET |
| Benched | TE | Travis Kelce KC | Owner | Wed Nov 26 11:32am ET |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 25 9:05am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 9:05am ET |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 9:05am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 9:05am ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 25 9:27am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:27am ET |
| Started | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 9:27am ET |
| Benched | WR | A.J. Brown PHI | Owner | Tue Nov 25 9:26am ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 9:26am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 9:26am ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 26 9:15am ET |
| Benched | RB | Tony Pollard TEN | Owner | Wed Nov 26 9:15am ET |
| Benched | D/ST | Chicago Bears CHI | Owner | Wed Nov 26 9:15am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 9:15am ET |
| Started | WR | Drake London ATL | Owner | Wed Nov 26 9:15am ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Wed Nov 26 9:15am ET |
| Benched | K | Cairo Santos CHI | Owner | Thu Nov 27 8:11pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 4:21pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 4:21pm ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 10:54pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 10:54pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 10:53pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 10:53pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 6:21pm ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 6:21pm ET |
| Started | RB | David Montgomery DET | Owner | Tue Nov 25 6:21pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 6:21pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 11:04pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 11:04pm ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 11:04pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 11:04pm ET |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 11:03pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 11:03pm ET |
| Benched | K | Evan McPherson CIN | Owner | Tue Nov 25 11:03pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 11:03pm ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Thu Nov 27 12:07am ET |
| Started | TE | AJ Barner SEA | Owner | Thu Nov 27 12:07am ET |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 3:29pm ET |
| Started | QB | Jordan Love GB | Owner | Wed Nov 26 3:29pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 8:53am ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 8:53am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Jayden Higgins HOU | Owner | Thu Nov 27 10:25am ET |
| Started | WR | Rome Odunze CHI | Owner | Thu Nov 27 10:25am ET |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 12:25pm ET |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 12:25pm ET |
| Started | RB | Kyle Monangai CHI | Owner | Wed Nov 26 12:25pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Wed Nov 26 12:25pm ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Tue Nov 25 11:35pm ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 11:35pm ET |