

| Benched | QB | Baker Mayfield TB | Owner | Thu Nov 27 10:41am ET |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 10:41am ET |
| Started | QB | Kirk Cousins ATL | Owner | Thu Nov 27 10:41am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 10:41am ET |
| Benched | WR | Drake London ATL | Owner | Fri Nov 28 8:43pm ET |
| Started | WR | D.K. Metcalf PIT | Owner | Fri Nov 28 8:43pm ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 4:26pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 4:26pm ET |
| Started | QB | Jared Goff DET | Owner | Tue Nov 25 4:26pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 4:26pm ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 10:51pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 10:51pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 10:51pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 10:51pm ET |
| Benched | TE | Dalton Kincaid BUF | Owner | Wed Nov 26 11:15pm ET |
| Started | WR | Malik Washington MIA | Owner | Wed Nov 26 11:15pm ET |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 11:15pm ET |
| Started | TE | Dalton Kincaid BUF | Owner | Wed Nov 26 11:15pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Wed Nov 26 11:15pm ET |
| Started | RB | Zonovan Knight ARI | Owner | Wed Nov 26 11:15pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 3:32pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 3:31pm ET |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 27 12:16pm ET |
| Benched | WR | Keenan Allen LAC | Owner | Thu Nov 27 12:16pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 5:30pm ET |
| Benched | QB | Marcus Mariota WAS | Owner | Tue Nov 25 5:30pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 5:29pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Nov 25 5:29pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 5:29pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 5:29pm ET |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 25 5:29pm ET |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 5:29pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 5:29pm ET |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 5:29pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 10:48pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:48pm ET |
| Started | WR | Zay Flowers BAL | Owner | Wed Nov 26 10:48pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 10:48pm ET |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 7:59pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 7:59pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 7:59pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:59pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 12:51pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Thu Nov 27 12:51pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 27 12:51pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 12:51pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Fri Nov 28 7:00pm ET |
| Started | QB | Aaron Rodgers PIT | Owner | Fri Nov 28 7:00pm ET |
| Benched | QB | Geno Smith LV | Owner | Tue Nov 25 4:23pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 4:23pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 4:23pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 4:23pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 4:23pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 4:23pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Nov 25 9:25am ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 25 9:25am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Nov 25 9:25am ET |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 25 9:25am ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 25 9:25am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 9:25am ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 8:39pm ET |
| Started | WR | Pat Bryant DEN | Owner | Tue Nov 25 8:39pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 8:39pm ET |
| Benched | TE | Darnell Washington PIT | Owner | Tue Nov 25 8:39pm ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 8:39pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 8:39pm ET |