

| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 8:16pm CT |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 8:16pm CT |
| Benched | TE | Dawson Knox BUF | Owner | Tue Nov 25 8:16pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 8:16pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:16pm CT |
| Started | TE | Gunnar Helm TEN | Owner | Tue Nov 25 8:16pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Justin Jefferson MIN | Owner | Wed Nov 26 8:48am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 8:48am CT |
| Benched | TE | Terrance Ferguson LAR | Owner | Tue Nov 25 9:43am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:43am CT |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 11:02am CT |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 11:02am CT |
| Started | TE | Jake Ferguson DAL | Owner | Wed Nov 26 11:02am CT |
| Started | TE | Theo Johnson NYG | Owner | Wed Nov 26 11:02am CT |
| Benched | QB | Mason Rudolph PIT | Owner | Thu Nov 27 5:46pm CT |
| Benched | TE | David Njoku CLE | Owner | Thu Nov 27 5:46pm CT |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 5:46pm CT |
| Started | TE | Tyler Warren IND | Owner | Thu Nov 27 5:46pm CT |
| Started | TE | AJ Barner SEA | Owner | Thu Nov 27 9:37am CT |
| Started | QB | Lamar Jackson BAL | Owner | Thu Nov 27 9:37am CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Thu Nov 27 9:37am CT |
| Benched | QB | Sam Darnold SEA | Owner | Thu Nov 27 9:37am CT |
| Started | QB | Sam Darnold SEA | Owner | Wed Nov 26 3:43pm CT |
| Benched | QB | Lamar Jackson BAL | Owner | Wed Nov 26 3:43pm CT |
| Started | D/ST | New England Patriots NE | Owner | Wed Nov 26 3:29pm CT |
| Started | WR | Tre Tucker LV | Owner | Wed Nov 26 3:29pm CT |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Wed Nov 26 3:29pm CT |
| Benched | WR | Tez Johnson TB | Owner | Wed Nov 26 3:29pm CT |
| Started | TE | T.J. Hockenson MIN | Owner | Tue Nov 25 6:41am CT |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 25 6:41am CT |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 25 6:41am CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 6:41am CT |
| Benched | QB | Jared Goff DET | Owner | Thu Nov 27 5:55am CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 5:55am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 6:37am CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 6:37am CT |
| Benched | K | Joey Slye TEN | Owner | Wed Nov 26 6:27pm CT |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 6:27pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Wed Nov 26 10:25pm CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 10:25pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 10:25pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 10:25pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 11:04am CT |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 11:04am CT |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Wed Nov 26 11:04am CT |
| Started | RB | Ollie Gordon II MIA | Owner | Wed Nov 26 11:04am CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 11:04am CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Wed Nov 26 11:04am CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 9:47am CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 9:47am CT |
| Benched | QB | Drake Maye NE | Owner | Wed Nov 26 9:31am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 9:31am CT |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 26 9:31am CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 9:31am CT |
| No starting lineup changes performed this week. |