

| No starting lineup changes performed this week. |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 11:36pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 11:36pm ET |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 11:33pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 11:33pm ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 11:33pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 11:33pm ET |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 11:33pm ET |
| Started | TE | Zach Ertz WAS | Owner | Wed Nov 26 11:33pm ET |
| Benched | QB | Cam Ward TEN | Owner | Tue Nov 25 12:38pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 12:38pm ET |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 25 12:38pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 12:38pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 12:38pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 12:38pm ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 27 4:26am ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 5:04pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 5:04pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 5:04pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 5:04pm ET |
| Benched | QB | Jordan Love GB | Owner | Wed Nov 26 9:47am ET |
| Benched | RB | Travis Etienne JAX | Owner | Wed Nov 26 9:47am ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 9:47am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 9:47am ET |
| Benched | K | Will Reichard MIN | Owner | Tue Nov 25 5:07pm ET |
| Started | K | Jake Bates DET | Owner | Tue Nov 25 5:07pm ET |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Tue Nov 25 5:07pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 5:07pm ET |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 8:29pm ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Wed Nov 26 8:29pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 8:28pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 8:28pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 8:28pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 8:28pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 12:40pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Thu Nov 27 12:40pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 12:40pm ET |
| Started | TE | Dalton Schultz HOU | Owner | Thu Nov 27 12:40pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 5:06pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 5:06pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 12:49pm ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 2:26am ET |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 2:26am ET |
| Started | RB | Trey Benson ARI | Owner | Wed Nov 26 2:26am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 2:26am ET |