

| Benched | WR | Tez Johnson TB | Owner | Tue Nov 25 6:56pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 6:56pm CT |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 1:22pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 1:22pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Xavier Worthy KC | Owner | Wed Nov 26 5:07pm CT |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Wed Nov 26 5:07pm CT |
| Started | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 5:07pm CT |
| Started | D/ST | Indianapolis Colts IND | Owner | Wed Nov 26 5:07pm CT |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 1:37pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 1:37pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 1:02am CT |
| Started | WR | Zay Flowers BAL | Owner | Thu Nov 27 1:02am CT |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 10:34am CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 10:34am CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 26 10:04pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 10:04pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 9:56am CT |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 9:56am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:56am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:56am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 12:33pm CT |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 12:33pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 12:33pm CT |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 12:33pm CT |
| Started | TE | Juwan Johnson NO | Owner | Wed Nov 26 12:33pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 10:35am CT |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 27 10:35am CT |
| Started | RB | Bhayshul Tuten JAX | Owner | Thu Nov 27 10:35am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 10:35am CT |